Elderly patients undergoing SBRT for inoperable early-stage NSCLC achieve similar outcomes to younger patients

Lung Cancer

Volumn 97, Issue , 2016, Pages 22-27

  Mancini, Brandon R ^a   Park, Henry S ^a   Harder, Eileen M ^a   Rutter, Charles E ^a   Corso, Christopher D ^a   Decker, Roy H ^a   Husain, Zain A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Elderly; Non small cell lung cancer; Stereotactic body radiation therapy; Toxicity

Indexed keywords

ACUTE TOXICITY; ADULT; AGED; ARTICLE; CANCER CONTROL; CANCER PATIENT; CANCER SURVIVAL; CHI SQUARE TEST; CHRONIC TOXICITY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; EARLY CANCER; ESOPHAGITIS; FATIGUE; FEMALE; FOLLOW UP; FOUR DIMENSIONAL COMPUTED TOMOGRAPHY; GERIATRIC PATIENT; GROUPS BY AGE; HEMOPTYSIS; HUMAN; INOPERABLE CANCER; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RADIATION PNEUMONIA; RADIATION SICKNESS; RETROSPECTIVE STUDY; STEREOTACTIC BODY RADIATION THERAPY; THORAX PAIN; TREATMENT PLANNING; CANCER STAGING; CARCINOMA, NON-SMALL-CELL LUNG; LUNG NEOPLASMS; MIDDLE AGED; PATHOLOGY; PROCEDURES; RADIOSURGERY; SURVIVAL; TREATMENT OUTCOME;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; RADIOSURGERY; RETROSPECTIVE STUDIES; SURVIVAL; TREATMENT OUTCOME;

EID: 84963985268     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2016.04.011     Document Type: Article

References (18)

1. National Comprehensive Cancer Network. Non-Small Cell Lung Cancer (Version 7.2015). Available at (accessed 08.27.15). http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf.
2. Vincent G.K., Velkoff V.A. U.S. Census Bureau. The Next Four Decades: the Older Population in the United States: 2010-2050 2010, U.S. Dept. of Commerce, Economics and Statistics Administration, U.S. Census Bureau, Washington, D.C.
3. Rueth N.M., Parsons H.M., Habermann E.B., et al. Surgical treatment of lung cancer: predicting postoperative morbidity in the elderly population. J. Thorac. Cardiovasc. Surg. 2012, 143:1314-1323.
4. Husain Z.A., Kim A.W., Yu J.B., Decker R.H., Corso C.D. Defining the high-risk population for mortality after resection of early stage NSCLC. Clin. Lung Cancer 2015, 16(6):e183-e187. Epub 2015 Apr 24.PMID: 25979646. 10.1016/j.cllc.2015.04.007.
5. Timmerman R., Paulus R., Galvin J., et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA 2010, 303:1070-1076.
6. Onishi H., Araki T., Shirato H., et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 2004, 101:1623-1631.
7. Baumann P., Nyman J., Hoyer M., et al. Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. J. Clin. Oncol. 2009, 27:3290-3296.
8. Rowe B.P., Boffa D.J., Wilson L.D., et al. Stereotactic body radiotherapy for central lung tumors. J. Thorac. Oncol. 2012, 7:1394-1399.
9. Ross C.C., Kim J.J., Chen Z.J., et al. A novel modified dynamic conformal arc technique for treatment of peripheral lung tumors using stereotactic body radiation therapy. Pract. Radiat. Oncol. 2011, 1:126-134.
10. Chang J.Y., Senan S., Paul M.A., et al. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Oncol. 2015, 16:630-637.
11. Haasbeek C.J., Lagerwaard F.J., Antonisse M.E., et al. Stage I nonsmall cell lung cancer in patients aged > or =75 years: outcomes after stereotactic radiotherapy. Cancer 2010, 116:406-414.
12. Nath S.K., Sandhu A.P., Kim D., et al. Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer. Radiother. Oncol. 2011, 99:12-17.
13. Hayashi S., Tanaka H., Kajiura Y., et al. Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer. Radiat. Oncol. 2014, 9:138.
14. Takeda A., Sanuki N., Eriguchi T., et al. Stereotactic ablative body radiation therapy for octogenarians with non-small cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2013, 86:257-263.
15. Sandhu A.P., Lau S.K., Rahn D., et al. Stereotactic body radiation therapy in octogenarians with stage I lung cancer. Clin. Lung Cancer 2014, 15:131-135.
16. Cannon N.A., Iyengar P., Choy H., et al. Stereotactic ablative body radiation therapy for tumors in the lung in octogenarians: a retrospective single institution study. BMC Cancer 2014, 14:971.
17. Palma D., Visser O., Lagerwaard F.J., et al. Treatment of stage I NSCLC in elderly patients: a population-based matched-pair comparison of stereotactic radiotherapy versus surgery. Radiother. Oncol. 2011, 101:240-244.
18. Samuels M.A., Kandula S., Koru-Sengul T., et al. Stereotactic body radiotherapy in patients with stage I non-small-cell lung cancer aged 75 years and older: retrospective results from a multicenter consortium. Clin. Lung Cancer 2013, 14:446-451.