Elderly ovarian cancer patients: An individual participant data meta-analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO)

European Journal of Cancer

Volumn 60, Issue , 2016, Pages 101-106

  Woopen, H ^a   Inci, G ^a   Richter, R ^a   Chekerov, R ^a   Ismaeel, F ^a   Sehouli, J ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Elderly; Recurrent ovarian cancer; Toxicity

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PLATINUM; TOPOTECAN; ANTINEOPLASTIC AGENT;

ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CARDIOVASCULAR DISEASE; COMORBIDITY; DIABETES MELLITUS; FEMALE; HUMAN; META ANALYSIS; OVARY CANCER; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; ADULT; AGED; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG THERAPY; EPIDEMIOLOGY; GERMANY; HEMATOLOGIC DISEASE; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; TREATMENT OUTCOME; TUMOR RECURRENCE; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARDIOVASCULAR DISEASES; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; FEMALE; GERMANY; HEMATOLOGIC DISEASES; HUMANS; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84963966338     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2016.03.008     Document Type: Article

References (16)

1. G. Freyer, W.P. Tew, and K.N. Moore Treatment and trials: ovarian cancer in older women Am Soc Clin Oncol Educ Book ASCO Am Soc Clin Oncol Meet 2013 227 235 10.1200/EdBook-AM.2013.33.227
2. H.A. Maas, R.F. Kruitwagen, V.E. Lemmens, S.H. Goey, and M.L. Janssen-Heijnen The influence of age and co-morbidity on treatment and prognosis of ovarian cancer: a population-based study Gynecol Oncol 97 2005 104 109 10.1016/j.ygyno.2004.12.026
3. F. Hilpert, P. Wimberger, A. du Bois, J. Pfisterer, and P. Harter Treatment of elderly ovarian cancer patients in the context of controlled clinical trials: a joint analysis of the AGO Germany experience Onkologie 35 2012 76 81 10.1159/000336829
4. I. Bruchim, M. Altaras, and A. Fishman Age contrasts in clinical characteristics and pattern of care in patients with epithelial ovarian cancer Gynecol Oncol 86 2002 274 278
5. G. Freyer, A.V. Tinker, and Gynecologic Cancer InterGroup Clinical trials and treatment of the elderly diagnosed with ovarian cancer Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 21 2011 776 781 10.1097/IGC.0b013e31821bb700
6. F. Hilpert, A. du Bois, E.R. Greimel, J. Hedderich, G. Krause, L. Venhoff, and et al. Feasibility, toxicity and quality of life of first-line chemotherapy with platinum/paclitaxel in elderly patients aged > or =70 years with advanced ovarian cancer-a study by the AGO OVAR Germany Ann Oncol Off J Eur Soc Med Oncol ESMO 18 2007 282 287 10.1093/annonc/mdl401
7. L. Talarico, G. Chen, and R. Pazdur Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration J Clin Oncol Off J Am Soc Clin Oncol 22 2004 4626 4631 10.1200/JCO.2004.02.175
8. C.A. Townsley, R. Selby, and L.L. Siu Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials J Clin Oncol Off J Am Soc Clin Oncol 23 2005 3112 3124 10.1200/JCO.2005.00.141
9. J. Sehouli, D. Stengel, P. Harter, C. Kurzeder, A. Belau, T. Bogenrieder, and et al. Topotecan weekly versus conventional 5-day schedule in patients with platinum-resistant ovarian cancer: a randomized multicenter phase II trial of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group J Clin Oncol Off J Am Soc Clin Oncol 29 2011 242 248 10.1200/JCO.2009.27.8911
10. J. Sehouli, D. Stengel, G. Oskay-Oezcelik, A.G. Zeimet, H. Sommer, P. Klare, and et al. Nonplatinum topotecan combinations versus topotecan alone for recurrent ovarian cancer: results of a phase III study of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group J Clin Oncol Off J Am Soc Clin Oncol 26 2008 3176 3182 10.1200/JCO.2007.15.1258
11. L. Balducci Supportive care in elderly cancer patients Curr Opin Oncol 21 2009 310 317 10.1097/CCO.0b013e32832b4f25
12. O. Trédan, J.-F. Geay, S. Touzet, R. Delva, B. Weber, J. Cretin, and et al. Carboplatin/cyclophosphamide or carboplatin/paclitaxel in elderly patients with advanced ovarian cancer? Analysis of two consecutive trials from the Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens Ann Oncol Off J Eur Soc Med Oncol ESMO 18 2007 256 262 10.1093/annonc/mdl400
13. L. Balducci Management of cancer in the elderly Oncol Williston Park N 20 2006 135 143 discussion 144, 146, 151-2
14. C.B. Steer Chemotherapy for ovarian cancer in the older adult Curr Treat Options Oncol 10 2009 159 170 10.1007/s11864-009-0093-5
15. J.E. Kurtz, M.C. Kaminsky, A. Floquet, A.S. Veillard, R. Kimmig, A. Dorum, and et al. Ovarian cancer in elderly patients: carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in late relapse: a Gynecologic Cancer Intergroup (GCIG) CALYPSO sub-study Ann Oncol Off J Eur Soc Med Oncol ESMO 22 2011 2417 2423 10.1093/annonc/mdr001
16. A. Luciani, L. Biganzoli, G. Colloca, C. Falci, B. Castagneto, I. Floriani, and et al. Estimating the risk of chemotherapy toxicity in older patients with cancer: the role of the Vulnerable Elders Survey-13 (VES-13) J Geriatr Oncol 6 2015 272 279 10.1016/j.jgo.2015.02.005