Increased cardiac output and preserved gas exchange despite decreased alveolar surface area in rats exposed to neonatal hyperoxia and adult hypoxia

American Journal of Respiratory Cell and Molecular Biology

Volumn 53, Issue 6, 2015, Pages 902-906

  Goss, Kara N ^a   Tepper, Robert S ^b   Lahm, Tim ^b   Roudebush, Richard L ^c   Ahlfeld, Shawn K ^d  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE;

ADULT; ALVEOLAR CAPILLARY MEMBRANE; ALVEOLAR SURFACE AREA; ANIMAL EXPERIMENT; ANIMAL MODEL; BODY WEIGHT; CAPILLARY WALL; CHRONIC LUNG DISEASE; CONTROLLED STUDY; GAS EXCHANGE; HEART OUTPUT; HEART RATE; HEART RIGHT VENTRICLE HYPERTROPHY; HYPEROXIA; HYPOXIA; LETTER; LUNG CAPILLARY; LUNG DIFFUSION; LUNG VOLUME; MORTALITY; NEWBORN; NONHUMAN; PREMATURE CHRONIC LUNG DISEASE; PULMONARY ARTERIAL DENSITY; PULMONARY HYPERTENSION; RAT; RESPIRATORY TRACT PARAMETERS; RIGHT VENTRICLE SYSTOLIC BLOOD PRESSURE; SYSTOLIC BLOOD PRESSURE; ANIMAL; CELL HYPOXIA; LUNG ALVEOLUS; LUNG GAS EXCHANGE; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CARDIAC OUTPUT; CELL HYPOXIA; HYPEROXIA; PULMONARY ALVEOLI; PULMONARY GAS EXCHANGE; RATS, SPRAGUE-DAWLEY;

EID: 84963812049     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2015-0100LE     Document Type: Letter

References (34)

1. Doyle LW, Faber B, Callanan C, Freezer N, Ford GW, Davis NM. Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescence. Pediatrics 2006;118:108-113.
2. Lum S, Kirkby J, Welsh L, Marlow N, Hennessy E, Stocks J. Nature and severity of lung function abnormalities in extremely pre-term children at 11 years of age. Eur Respir J 2011;37:1199-1207.
3. Bates ML, Farrell ET, Eldridge MW. Abnormal ventilatory responses in adults born prematurely. N Engl J Med 2014;370:584-585.
4. Ahlfeld SK, Conway SJ. Assessment of inhibited alveolar-capillary membrane structural development and function in bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol 2014;100:168-179.
5. Husain AN, Siddiqui NH, Stocker JT. Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia. Hum Pathol 1998;29:710-717.
6. Thibeault DW, Truog WE, Ekekezie II. Acinar arterial changes with chronic lung disease of prematurity in the surfactant era. Pediatr Pulmonol 2003;36:482-489.
7. Balinotti JE, Chakr VC, Tiller C, Kimmel R, Coates C, Kisling J, Yu Z, Nguyen J, Tepper RS. Growth of lung parenchyma in infants and toddlers with chronic lung disease of infancy. Am J Respir Crit Care Med 2010;181:1093-1097.
8. Kaplan E, Bar-Yishay E, Prais D, Klinger G, Mei-Zahav M, Mussaffi H, Steuer G, Hananya S, Matyashuk Y, Gabarra N, et al. Encouraging pulmonary outcome for surviving, neurologically intact, extremely premature infants in the postsurfactant era. Chest 2012;142:725-733.
9. Bhat R, Salas AA, Foster C, Carlo WA, Ambalavanan N. Prospective analysis of pulmonary hypertension in extremely low birth weight infants. Pediatrics 2012;129:e682-e689.
10. Yee M, White RJ, Awad HA, Bates WA, McGrath-Morrow SA, O'Reilly MA. Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice. Am J Pathol 2011;178:2601-2610.
11. Mourani PM, Sontag MK, Younoszai A, Miller JI, Kinsella JP, Baker CD, Poindexter BB, Ingram DA, Abman SH. Early pulmonary vascular disease in preterm infants at risk for bronchopulmonary dysplasia. Am J Respir Crit Care Med 2015;191:87-95.
12. Khemani E, McElhinney DB, Rhein L, Andrade O, Lacro RV, Thomas KC, Mullen MP. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics 2007;120:1260-1269.
13. Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol 2011;31:635-640.
14. D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT, et al. Survival in patients with primary pulmonary hypertension: Results from a national prospective registry. Ann Intern Med 1991;115:343-349.
15. Lewandowski AJ, Bradlow WM, Augustine D, Davis EF, Francis J, Singhal A, Lucas A, Neubauer S, McCormick K, Leeson P. Right ventricular systolic dysfunction in young adults born preterm. Circulation 2013;128:713-720.
16. Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump A, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, et al. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. Am J Physiol Lung Cell Mol Physiol 2015; 308:L797-L806.
17. Ahlfeld SK, Gao Y, Conway SJ, Tepper RS. Relationship of structural to functional impairment during alveolar-capillary membrane development. Am J Pathol 2015;185:913-919.
18. Kimura J, Deutsch GH. Key mechanisms of early lung development. Pediatr Dev Pathol 2007;10:335-347.
19. Hughes JM, Pride NB. Examination of the carbon monoxide diffusing capacity (DL(CO)) in relation to its KCO and VA components. Am J Respir Crit Care Med 2012;186:132-139.
20. Hughes JM, Pride NB. In defence of the carbon monoxide transfer coefficient Kco (TL/VA). Eur Respir J 2001;17:168-174.
21. Ramage JE Jr, Coleman RE, MacIntyre NR. Rest and exercise cardiac output and diffusing capacity assessed by a single slow exhalation of methane, acetylene, and carbon monoxide. Chest 1987;92:44-50.
22. Ahlfeld SK, Gao Y, Wang J, Horgusluoglu E, Bolanis E, Clapp DW, Conway SJ. Periostin downregulation is an early marker of inhibited neonatal murine lung alveolar septation. Birth Defects Res A Clin Mol Teratol 2013;97:373-385.
23. Howell K, Preston RJ, McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 2003;547:133-145.
24. Reinke C, Bevans-Fonti S, Grigoryev DN, Drager LF, Myers AC, Wise RA, Schwartz AR, Mitzner W, Polotsky VY. Chronic intermittent hypoxia induces lung growth in adult mice. Am J Physiol Lung Cell Mol Physiol 2011;300:L266-L273.
25. Agostoni P, Swenson ER, Bussotti M, Revera M, Meriggi P, Faini A, Lombardi C, Bilo G, Giuliano A, Bonacina D, et al. High-altitude exposure of three weeks duration increases lung diffusing capacity in humans. J Appl Physiol (1985) 2011;110:1564-1571.
26. Llapur CJ, Martinez MR, Caram MM, Bonilla F, Cabana C, Yu Z, Tepper RS. Increased lung volume in infants and toddlers at high compared to low altitude. Pediatr Pulmonol 2013;48:1224-1230.
27. Moore LG, Niermeyer S, Zamudio S. Human adaptation to high altitude: Regional and life-cycle perspectives. Am J Phys Anthropol 1998;25-64.
28. Elliott JE, Choi Y, Laurie SS, Yang X, Gladstone IM, Lovering AT. Effect of initial gas bubble composition on detection of inducible intrapulmonary arteriovenous shunt during exercise in normoxia, hypoxia, or hyperoxia. J Appl Physiol (1985) 2011;110:35-45.
29. Lovering AT, Romer LM, Haverkamp HC, Pegelow DF, Hokanson JS, Eldridge MW. Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans. J Appl Physiol (1985) 2008;104:1418-1425.
30. Galambos C, Sims-Lucas S, Abman SH. Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia. Ann Am Thorac Soc 2013;10:474-481.
31. Lovering AT, Elliott JE, Laurie SS, Beasley KM, Gust CE, Mangum TS, Gladstone IM, Duke JW. Ventilatory and sensory responses in adult survivors of preterm birth and bronchopulmonary dysplasia with reduced exercise capacity. Ann Am Thorac Soc 2014;11:1528-1537.
32. Duke JW, Elliott JE, Laurie SS, Beasley KM, Mangum TS, Hawn JA, Gladstone IM, Lovering AT. Pulmonary gas exchange efficiency during exercise breathing normoxic and hypoxic gas in adults born very preterm with low diffusion capacity. J Appl Physiol (1985) 1985;2014:473-481.
33. Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, et al. Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation 2006;114:1883-1891.
34. Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, et al. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. J Am Coll Cardiol 2013;62:D22-D33.