The use of noninvasive prenatal testing in obstetric care: Educational resources, practice patterns, and barriers reported by a national sample of clinicians

Prenatal Diagnosis

Volumn 36, Issue 6, 2016, Pages 499-506

  Farrell, Ruth M ^a   Agatisa, Patricia K ^a   Mercer, Mary Beth ^a   Mitchum, Ariane G ^a   Coleridge, Marissa B ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL PRACTICE; FEMALE; HEALTH SURVEY; HUMAN; MALE; MEDICAL EDUCATION; MEDICAL ETHICS; MEDICAL LITERATURE; NON INVASIVE PROCEDURE; OBSTETRIC PROCEDURE; PATIENT COUNSELING; PATIENT REFERRAL; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; ACCESS TO INFORMATION; BLOOD; EDUCATION; GENETIC COUNSELING; GENETICS; INFORMATION SEEKING; MATERNAL SERUM SCREENING TEST; MIDDLE AGED; OBSTETRICS; PERINATOLOGY; QUESTIONNAIRE; VERY ELDERLY;

DNA;

ACCESS TO INFORMATION; ADULT; AGED; AGED, 80 AND OVER; DNA; ETHICS, MEDICAL; GENETIC COUNSELING; HUMANS; INFORMATION SEEKING BEHAVIOR; MATERNAL SERUM SCREENING TESTS; MIDDLE AGED; OBSTETRICS; PERINATOLOGY; PRACTICE PATTERNS, PHYSICIANS'; PRENATAL DIAGNOSIS; SURVEYS AND QUESTIONNAIRES;

EID: 84963718543     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.4812     Document Type: Article

References (42)

1. Musci TJ, Fairbrother G, Batey A, et al. Non-invasive prenatal testing with cell-free DNA: US physician attitudes toward implementation in clinical practice. Prenat Diagn 2013;424-8.
2. Wapner RJ, Babiarz JE, Levy B, et al. Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes. Am J Obstet Gynecol 2015;212:332-e1.
3. Norton ME, Jacobsson B, Swamy GK, et al.. Cell-free DNA analysis for noninvasive examination of trisomy. NEJM 2015;372:1589-97.
4. Van Lith JMM, Faas BHW, Bianchi DW. Controversies in prenatal diagnosis 1: NIPT for chromosome abnormalities should be offered to women with low a priori risk. Prenat Diagn 2015;35:8-14.
5. ACOG Committee Opinion No. 640. Cell-free DNA screening for fetal aneuploidy. American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine. 2015.
6. Benn PA, Chapman AR. Practical and ethical considerations of noninvasive prenatal diagnosis. JAMA 2009;301:2154-56.
7. de Jong A, Dondorp WJ, Macville MV, et al.. Microarrays as a diagnostic tool in prenatal screening strategies: ethical reflection. Hum Genet 2014; 133:163-72.
8. Dondorp WJ, de Wert G, Bombard Y, et al. Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Eur J Hum Gen 2015. DOI:10.1038/ejhg.2015.5.
9. Hofman KJ, Tambor ES, Chase GA, et al. Physicians' knowledge of genetics and genetic tests. Acad Med 1993;68:625-32.
10. Suther S, Goodson P. Barriers to the provision of genetic services by primary care physicians: a systematic review of the literature. Genet Med 2002;5:70-6.
11. Macri CJ, Gaba ND, Sitzer LM, et al. Implementation and evaluation of a genetics curriculum to improve obstetric-gynecologists residents' knowledge and skills in genetic diagnosis and counseling. Am J Obstet Gynecol 2005;193:1794-97.
12. Cleary-Goldman J, Morgan MA, Malone FD, et al. Screening for Down syndrome: practice patterns and knowledge of obstetricians and gynecologists. Obstet Gynecol 2006;107:11-7.
13. Darcy D, Tian L, Taylor J, Schrijver I. Cystic fibrosis carrier screening in obstetric clinical practice: knowledge, practices, and barriers, a decade after publication of screening guidelines. Genet Test Mol Biomarkers 2011;15:517-23.
14. Morgan MA, Driscoll DA, Mennuti MT, Schulkin J. Practice patterns for obstetrician-gynecologists regarding preconception and prenatal screening for cystic fibrosis. Genet Med 2004;6:450-55.
15. Ready K, Haque IS, Srinivasan BS, Marshall JR. Knowledge and attitudes regarding expanded career screening among women's healthcare providers. Fertil Steril 2012;97:407-13.
16. Driscoll DA, Morgan MA, Schulkin J. Screening for Down syndrome: changing practice of obstetricians. Am J Obstet Gynecol 2009;200(459):e1-9.
17. Farrell RM, Nutter B, Agatisa PK. Patient-centered prenatal counseling: aligning obstetric healthcare professionals with the needs of pregnant women. Women Health 2015;55:280-96.
18. Harris PA, Taylor R, Thielke R, et al. Research electronic data and workflow process for providing translational research informatics support. J Biomed Inform 2009;42:377-81.
19. IBM CorpReleased 2010. IBM SPSS Statistics for Windows, Version 19.0. IBM Corp: Armonk, NY; 2010.
20. Minkoff H, Berkowitz R. The case for universal prenatal genetic counseling. Obstet Gynecol 2014;123:1335-38.
21. Pergament E, Pergament D. Reproductive decisions after fetal genetic counselling. Best Pract Res Clin Obstet Gynaecol 2012; 26: 517-529.
22. Institute of Medicine. Conflict of Interest in Medical Research, Education, and Practice. National Academies Press: Washington DC; 2009.
23. Agarwal A, Sayres LC, Cho MK, et al. Commercial Landscape of noninvasive prenatal testing in the United States. Prenat Diagn 2013;33:521-31.
24. Mikat-Stevens NA, Larson IA, Tarini BA. Primary-care providers' perceived barriers to integration of genetics services: a systematic review of the literature. Genet Med 2015;17:169-76.
25. Alexander E, Kelly S, Kerzin-Storrar L. Non-invasive prenatal testing: UK genetic counselors' experiences and perspectives. J Genet Couns 2015;24:300-11.
26. Sachs A, Blanchard L, Buchanan A, et al. Recommended pre-test counseling points for noninvasive prenatal testing using cell-free DNA: a 2015 perspective. Prenat Diagn 2015;35:968-71.
27. Bernhardt BA, Soucier D, Hanson K, et al.. Women's experiences receiving abnormal prenatal chromosomal microarray testing results. Genet Med 2013;15:139-45.
28. Reiff M, Bernhardt BA, Mulchandani S, et al. What does it mean? Uncertainties in understanding results of chromosomal microarray testing. Genet Med 2012;14:250-58.
29. Pergament E. Controversies and challenges of array comparative genomic hybridization in prenatal genetic diagnosis. Genet Med 2007;9:596.
30. Martin JA, Hamilton BE, Ventura SJ, et al. Births: final data for 2009. Natl Vital Stat Rep 2011;50:1-70.
31. Farrell RM, Agatisa PK, Mercer MB, et al.. Balancing risks: the core of women's decisions about noninvasive prenatal testing. AJOB Empir Bioeth 2015;6:42-53.
32. Minear MA, Alessi S, Allyse M, et al. Noninvasive prenatal genetic testing: current and emerging ethical, legal, and social Issues. Annu Rev Genomics Hum Genet 2015;16:369-98.
33. Agatisa PK, Mercer MB, Leek AC, et al. A first look at women's perspectives on noninvasive prenatal testing to detect sex chromosome aneuploidies and microdeletion syndromes. Pren Diagn 2015;35:1-7.
34. Lyerly AD, Mitchell LM, Armstrong EM, et al. Risks, values, and decision making surrounding pregnancy. Obstet Gynecol 2007;109:979-84.
35. Haymon L, Simi E, Moyer K, et al. Clinical implementation of noninvasive prenatal testing among maternal fetal medicine specialists. Prenat Diagn 2014;34:416-23.
36. Benn P, Cuckle H, Pergmaent E. Noninvasive prenatal testing for aneuploidy: current status and future prospects. Ultrasound Obstet Gynecol 2013;42(1):15-33.
37. Institute of Medicine (US) Roundatable on Translating Genomic-Based Research for Health. Innovations in Service Delivery in the Age of Genomics: Workshop Summary. National Academies Press: Washington, DC; 2009.
38. Farrell RM, Nutter B, Agatisa PK. Meeting patients' education and decision-making needs for first trimester prenatal aneuploidy screening. Prenat Diagn 2011;3:1222-28.
39. Van den Berg M, Timmermans DR, Ten Kate LP, et al. Are pregnant women making informed choices about prenatal screening? Genet Med 2005;7:332-38.
40. Khoshnood B, De Vigan C, Blondel B, et al. Women's interpretation of an abnormal result on measurement of fetal nuchal translucency and maternal serum screening for prenatal testing of Down syndrome. Ultrasound Obstet Gynecol 2006;28:242-48.
41. Hing E, Burt CW. Characteristics of office-based physicians and their medical practices: United States, 2005-2006. Vital and health statistics. Series 13, Data from the National Health Survey, 2008;166:1-34.
42. Halter M, Drennan V, Chattapadhvay K, et al. The contribution of physician assistants in primary care: a systematic review. BMC Health Serv Res 2013;13:223.