A 3-month course of ciprofloxacin does not prevent BK virus replication in heavily immunosuppressed kidney-transplant patients

Journal of Clinical Virology

Volumn 79, Issue , 2016, Pages 61-67

  Lebreton, Marine ^a   Esposito, Laure ^a   Mengelle, Catherine ^b   Del Bello, Arnaud ^a   Delarche, Antoine ^a,c   Dörr, Gaëlle ^a,c   Milongo, David ^a,c   Marion, Olivier ^a,b   Izopet, Jacques ^b,c   Kamar, Nassim ^a,b,c  

^a CHU RANGUEIL   (France)

^b CHU PURPAN   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Apheresis; BK virus; Kidney transplantation; Polyclonal antibodies; Quinolones; Rituximab

Indexed keywords

AZATHIOPRINE; BASILIXIMAB; BELATACEPT; CIPROFLOXACIN; CYCLOSPORIN A; ECULIZUMAB; IMMUNOGLOBULIN; LEVOFLOXACIN; MYCOPHENOLIC ACID; QUINOLONE DERIVATIVE; RITUXIMAB; STEROID; TACROLIMUS; VALGANCICLOVIR; ANTIVIRUS AGENT; IMMUNOSUPPRESSIVE AGENT;

ACHILLES TENDINITIS; ACUTE GRAFT REJECTION; ADULT; APHERESIS; ARTICLE; BK VIRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DESENSITIZATION; DRUG DOSE REDUCTION; FEMALE; FOCAL GLOMERULOSCLEROSIS; GRAFT SURVIVAL; HUMAN; IMMUNOADSORPTION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FUNCTION; KIDNEY GRAFT; MALE; MIDDLE AGED; PLASMAPHERESIS; PNEUMOCYSTIS JIROVECI; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETRANSPLANTATION; TREATMENT DURATION; VIREMIA; VIRUS REPLICATION; CHEMOPROPHYLAXIS; GRAFT RECIPIENT; GROWTH, DEVELOPMENT AND AGING; KIDNEY TRANSPLANTATION; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ANTIVIRAL AGENTS; BK VIRUS; CHEMOPREVENTION; CIPROFLOXACIN; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; TRANSPLANT RECIPIENTS; TREATMENT OUTCOME; VIRUS REPLICATION;

EID: 84963704484     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2016.04.004     Document Type: Article

References (13)

1. Hirsch H.H., Randhawa P. BK polyomavirus in solid organ transplantation. Am. J. Transplant. 2013, 13(Suppl. 4):179-188.
2. Hirsch H.H., Randhawa P. Practice ASTIDCo: bK virus in solid organ transplant recipients. Am. J. Transplant. 2009, 9(Suppl. 4):S136-46.
3. Ali S.H., Chandraker A., DeCaprio J.A. Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antivir. Ther. 2007, 12:1-6.
4. Randhawa P.S. Anti-BK virus activity of ciprofloxacin and related antibiotics. Clin. Infect. Dis. 2005, 41:1366-1367. (author reply 67).
5. Sharma B.N., Li R., Bernhoff E., Gutteberg T.J., Rinaldo C.H. Fluoroquinolones inhibit human polyomavirus BK (BKV) replication in primary human kidney cells. Antivir. Res. 2011, 92:115-123.
6. Gabardi S., Waikar S.S., Martin S., Roberts K., Chen J., Borgi L., et al. Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation. Clin. J. Am. Soc. Nephrol. 2010, 5:1298-1304.
7. Wojciechowski D., Chanda R., Chandran S., Lee B., Webber A., Macaraig M., et al. Ciprofloxacin prophylaxis in kidney transplant recipients reduces BK virus infection at 3 months but not at 1 year. Transplantation 2012, 94:1117-1123.
8. Knoll G.A., Humar A., Fergusson D., Johnston O., House A.A., Kim S.J., et al. Levofloxacin for BK virus prophylaxis following kidney transplantation: a randomized clinical trial. JAMA 2014, 312:2106-2114.
9. Leung A.Y., Chan M.T., Yuen K.Y., Cheng V.C., Chan K.H., Wong C.L., et al. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin. Infect. Dis. 2005, 40:528-537.
10. Miller A.N., Glode A., Hogan K.R., Schaub C., Kramer C., Stuart R.K., et al. Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. Biol. Blood Marrow Transplant. 2011, 17:1176-1181.
11. Sharif A., Alachkar N., Bagnasco S., Geetha D., Gupta G., Womer K., et al. Incidence and outcomes of BK virus allograft nephropathy among ABO- and HLA-incompatible kidney transplant recipients. Clin. J. Am. Soc. Nephrol. 2012, 7:1320-1327.
12. Lee B.T., Gabardi S., Grafals M., Hofmann R.M., Akalin E., Aljanabi A., et al. Efficacy of levofloxacin in the treatment of BK viremia: a multicenter, double-blinded, randomized, placebo-controlled trial. Clin. J. Am. Soc. Nephrol. 2014, 9:583-589.
13. Zeidan S., Esposito L., Rostaing L., Kamar N. The Achilles tendon of preventing BK virus nephropathy. Transpl. Infect. Dis. 2013, 15:E268-9.