Liver: Osteopontin and HMGB1: Novel regulators of HSC activation

Nature Reviews Gastroenterology and Hepatology

Volumn 13, Issue 6, 2016, Pages 320-322

  Borthwick, Lee A ^a   Mann, Derek A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; OSTEOPONTIN; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

AUTOCRINE EFFECT; CELL ACTIVATION; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; HUMAN; LIVER FIBROSIS; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; STELLATE CELL; HEPATIC STELLATE CELL; LIVER;

HEPATIC STELLATE CELLS; HMGB1 PROTEIN; HUMANS; LIVER; OSTEOPONTIN;

EID: 84963613819     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2016.58     Document Type: Short Survey

References (10)

1. Subraman, V., Thiyagarajan, M., Malathi, N. & Rajan, S. T. OPN-revisited. J. Clin. Diagn. Res. 9, ZE10-ZE13 (2015).
2. Rittling, S. R. & Singh, R. Osteopontin in immune-mediated diseases. J. Dent. Res. 94, 1638-1645 (2015).
3. Arriazu, E. et al. Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury. Gut http://dx.doi.org/10.1136/gutjnl-2015-310752 (2016).
4. Wang, X. et al. Osteopontin induces ductular reaction contributing to liver fibrosis. Gut 63, 1805-1818 (2014).
5. Coombes, J. D. et al. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut 64, 1120-1131 (2015).
6. Matsue, Y. et al. Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection. PLoS ONE 10, e0118744 (2015).
7. Li, L. C., Gao, J. & Li, J. Emerging role of HMGB1 in fibrotic diseases. J. Cell. Mol. Med. 18, 2331-2339 (2014).
8. Bonaldi, T. et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J. 22, 5551-5560 (2003).
9. Greenhalgh, S. N., Conroy, K. P. & Henderson, N. C. Cre-ativity in the liver: transgenic approaches to targeting hepatic nonparenchymal cells. Hepatology 61, 2091-2099 (2015).
10. Kazanecki, C. C., Uzwiak, D. J. & Denhardt, D. T. Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J. Cell. Biochem. 102, 912-924 (2007).