NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

Cell Host and Microbe

Volumn 19, Issue 4, 2016, Pages 515-528

  Guo, Haitao ^a   König, Renate ^b,c   Deng, Meng ^a,d   Riess, Maximilian ^c   Mo, Jinyao ^e   Zhang, Lu ^a   Petrucelli, Alex ^a   Yoh, Sunnie M ^b   Barefoot, Brice ^f   Samo, Melissa ^f   Sempowski, Gregory D ^f   Zhang, Aiping ^g   Colberg Poley, Anamaris M ^g,h   Feng, Hui ^a   Lemon, Stanley M ^a,e   Liu, Yong ^a,e   Zhang, Yanping ^a,e   Wen, Haitao ^a   Zhang, Zhigang ^a   Damania, Blossom ^a,e   Tsao, Li Chung ^a   Wang, Qi ^a   Su, Lishan ^a,e   Duncan, Joseph A ^a,e   Chanda, Sumit K ^b   Ting, Jenny P Y ^a,e   more..

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b BURNHAM INSTITUTE   (United States)

^c PAUL EHRLICH INSTITUT   (Germany)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^h GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BINDING PROTEIN; INTERFERON; NLRX1 PROTEIN; STING PROTEIN; TBK1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; BETA INTERFERON; DNA VIRUS; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MPYS PROTEIN, MOUSE; NLRX1 PROTEIN, MOUSE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DNA VIRUS; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; INNATE IMMUNITY; MALE; MONOCYTE; MOUSE; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION; VIRUS IMMUNITY; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; DNA VIRUS INFECTION; DOWN REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; VIROLOGY;

ANIMALS; DNA VIRUS INFECTIONS; DNA VIRUSES; DOWN-REGULATION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, INNATE; INTERFERON-BETA; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; VIRUS REPLICATION;

EID: 84963595977     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2016.03.001     Document Type: Article

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