Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial

Diabetes, Obesity and Metabolism

Volumn 18, Issue 6, 2016, Pages 633-637

  Tepper, S ^a   Shahar, D R ^a   Geva, D ^a   Ish Shalom, S ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b Elisha Medical Center   (Israel)

Author keywords

clinical trial; dietary intervention; insulin; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; INSULIN; PLACEBO; VITAMIN D; 25-HYDROXYVITAMIN D; BIOLOGICAL MARKER;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTHROPOMETRIC PARAMETERS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; DEMOGRAPHY; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LONG TERM CARE; MALE; NORMAL HUMAN; PARATHYROID HORMONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; TREATMENT DURATION; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; ASYMPTOMATIC DISEASE; BIOLOGICAL MODEL; BLOOD; DIET THERAPY; DIETARY SUPPLEMENT; HOMEOSTASIS; MIDDLE AGED; PHYSIOLOGY; YOUNG ADULT;

ADULT; AGED; ASYMPTOMATIC DISEASES; BIOMARKERS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; HOMEOSTASIS; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; VITAMIN D; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 84963541967     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12650     Document Type: Article

References (18)

1. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008; 87: S1080–S1086.
2. Azizi E, Pavlotsky F, Vered I, Kudish AI. Occupational exposure to Solar UVB and seasonal monitoring of serum levels of 25-hydroxy Vitamin D3: a case–control study. Photochem Photobiol 2009; 85: 1240–1244.
3. Vu LH, Whiteman DC, van der Pols JC, Kimlin MG, Neale RE. Serum vitamin D levels in office workers in a subtropical climate. Photochem Photobiol 2011; 87: 714–720.
4. Palomer X, González-Clemente J, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab 2008; 10: 185–197.
5. Kayaniyil S, Vieth R, Retnakaran R et al. Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010; 33: 1379–1381.
6. Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am J Clin Nutr 2011; 94: 225–233.
7. Tepper S, Shahar D, Geva D et al. Identifying the threshold for vitamin D insufficiency in relation to cardiometabolic markers. Nutr Metab Cardiovasc Dis 2014; 24: 489–494.
8. Tzotzas T, Papadopoulou FG, Tziomalos K et al. Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab 2010; 95: 4251–4257.
9. Asemi Z, Samimi M, Tabassi Z, Shakeri H, Esmaillzadeh A. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr 2013; 143: 1432–1438.
10. Harris S, Pittas A, Palermo N. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab 2012; 14: 789–794.
11. Forouhi N, Menon R, Sharp S et al. Effects of vitamin D2 or D3 supplementation on glycaemic control and cardiometabolic risk among people at risk of type 2 diabetes: results of a randomized double-blind placebo-controlled trial. Diabetes Obes Metab 2015; 18: 392–400.
12. Wood AD, Secombes KR, Thies F et al. Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab 2012; 97: 3557–3568.
13. Chasan-Taber S, Rimm EB, Stampfer MJ et al. Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology 1996; 7: 81–86.
14. Glanz K, Yaroch AL, Dancel M et al. Measures of sun exposure and sun protection practices for behavioral and epidemiologic research. Arch Dermatol 2008; 144: 217.
15. Muldowney S, Lucey AJ, Hill TR et al. Incremental cholecalciferol supplementation up to 15 µg/d throughout winter at 51–55° N has no effect on biomarkers of cardiovascular risk in healthy young and older adults. J Nutr 2012; 142: 1519–1525.
16. Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013; 97: 774–781.
17. Song Y, Manson JE, Tinker L et al. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women the Women's Health Initiative Observational Study. Diabetes Care 2007; 30: 1747–1752.
18. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ et al. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med 2016; 176: 175–183.