-
1
-
-
0020596734
-
Hamster preproglucagon contains the sequence of glucagon and two related peptides
-
Bell GI, Santerre RF, Mullenbach GT. Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 1983; 302: 716-718.
-
(1983)
Nature
, vol.302
, pp. 716-718
-
-
Bell, G.I.1
Santerre, R.F.2
Mullenbach, G.T.3
-
2
-
-
0023107555
-
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
-
Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 1987; 79: 616-619.
-
(1987)
J Clin Invest
, vol.79
, pp. 616-619
-
-
Mojsov, S.1
Weir, G.C.2
Habener, J.F.3
-
3
-
-
0023104829
-
Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
-
Holst JJ, Orskov C, Nielsen OV, et al. Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FEBS Lett 1987; 211: 169-174.
-
(1987)
FEBS Lett
, vol.211
, pp. 169-174
-
-
Holst, J.J.1
Orskov, C.2
Nielsen, O.V.3
-
4
-
-
0036373430
-
Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients
-
Vilsboll T, Krarup T, Madsbad S, et al. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabetologia 2002; 45: 1111-1119.
-
(2002)
Diabetologia
, vol.45
, pp. 1111-1119
-
-
Vilsboll, T.1
Krarup, T.2
Madsbad, S.3
-
5
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
-
(1996)
Nature
, vol.379
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
-
6
-
-
0029859220
-
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
-
Tang-Christensen M, Larsen PJ, Göke R, et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 1996; 271: R848-R856.
-
(1996)
Am J Physiol
, vol.271
, pp. R848-R856
-
-
Tang-Christensen, M.1
Larsen, P.J.2
Göke, R.3
-
7
-
-
0032005005
-
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
-
Flint A, Raben A, Astrup A, et al. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998; 101: 515-520.
-
(1998)
J Clin Invest
, vol.101
, pp. 515-520
-
-
Flint, A.1
Raben, A.2
Astrup, A.3
-
8
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
-
Knudsen LB, Nielsen PF, Huusfeldt PO, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000; 43: 1664-1669.
-
(2000)
J Med Chem
, vol.43
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
-
9
-
-
84899585635
-
Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study
-
Pratley RE, Nauck MA, Barnett AH, et al. Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study. Lancet Diabetes Endocrinol 2014; 4: 289-297.
-
(2014)
Lancet Diabetes Endocrinol
, vol.4
, pp. 289-297
-
-
Pratley, R.E.1
Nauck, M.A.2
Barnett, A.H.3
-
10
-
-
84908177336
-
Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial
-
Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. Lancet 2014; 384: 1349-1357.
-
(2014)
Lancet
, vol.384
, pp. 1349-1357
-
-
Dungan, K.M.1
Povedano, S.T.2
Forst, T.3
-
11
-
-
84936166069
-
A randomized, controlled trial of 3.0 mg of liraglutide in weight management
-
Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med 2015; 373: 11-22.
-
(2015)
N Engl J Med
, vol.373
, pp. 11-22
-
-
Pi-Sunyer, X.1
Astrup, A.2
Fujioka, K.3
-
12
-
-
84907495472
-
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
-
Secher A, Jelsing J, Baquero AF, et al. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest 2014; 124: 4473-4488.
-
(2014)
J Clin Invest
, vol.124
, pp. 4473-4488
-
-
Secher, A.1
Jelsing, J.2
Baquero, A.F.3
-
13
-
-
0030667056
-
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
-
Nauck MA, Niedereichholz U, Ettler R, et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273: E981-E988.
-
(1997)
Am J Physiol
, vol.273
, pp. E981-E988
-
-
Nauck, M.A.1
Niedereichholz, U.2
Ettler, R.3
-
14
-
-
67649636449
-
Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
-
Ruttimann EB, Arnold M, Hillebrand JJ, et al. Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms. Endocrinology 2009; 150: 1174-1181.
-
(2009)
Endocrinology
, vol.150
, pp. 1174-1181
-
-
Ruttimann, E.B.1
Arnold, M.2
Hillebrand, J.J.3
-
15
-
-
66649088029
-
Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
-
Hayes MR, Bradley L, Grill HJ. Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. Endocrinology 2009; 150: 2654-2659.
-
(2009)
Endocrinology
, vol.150
, pp. 2654-2659
-
-
Hayes, M.R.1
Bradley, L.2
Grill, H.J.3
-
16
-
-
84869788004
-
Vagal afferents mediate early satiation and prevent flavour avoidance learning in response to intraperitoneally infused exendin-4
-
Labouesse MA, Stadlbauer U, Weber E, et al. Vagal afferents mediate early satiation and prevent flavour avoidance learning in response to intraperitoneally infused exendin-4. J Neuroendocrinol 2012; 24: 1505-1516.
-
(2012)
J Neuroendocrinol
, vol.24
, pp. 1505-1516
-
-
Labouesse, M.A.1
Stadlbauer, U.2
Weber, E.3
-
17
-
-
79959404178
-
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
-
Nauck MA, Kemmeries G, Holst JJ, et al. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 2011; 60: 1561-1565.
-
(2011)
Diabetes
, vol.60
, pp. 1561-1565
-
-
Nauck, M.A.1
Kemmeries, G.2
Holst, J.J.3
-
18
-
-
84860243253
-
Liraglutide: short-lived effect on gastric emptying/long lasting effects on body weight
-
Jelsing J, Vrang N, Hansen G, et al. Liraglutide: short-lived effect on gastric emptying/long lasting effects on body weight. Diabetes Obes Metab 2012; 14: 531-538.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 531-538
-
-
Jelsing, J.1
Vrang, N.2
Hansen, G.3
-
19
-
-
84902254986
-
Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite, and energy metabolism in obese, non-diabetic adults
-
van Can J, Sloth B, Jensen CB, et al. Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite, and energy metabolism in obese, non-diabetic adults. Int J Obes (Lond) 2014; 38: 784-793.
-
(2014)
Int J Obes (Lond)
, vol.38
, pp. 784-793
-
-
van Can, J.1
Sloth, B.2
Jensen, C.B.3
-
20
-
-
77956301808
-
Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides
-
Vrang N, Larsen PJ. Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides. Prog Neurobiol 2010; 92: 442-462.
-
(2010)
Prog Neurobiol
, vol.92
, pp. 442-462
-
-
Vrang, N.1
Larsen, P.J.2
-
21
-
-
79952394105
-
Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function
-
Barrera JG, Jones KR, Herman JP, et al. Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci 2011; 31: 3904-3913.
-
(2011)
J Neurosci
, vol.31
, pp. 3904-3913
-
-
Barrera, J.G.1
Jones, K.R.2
Herman, J.P.3
-
22
-
-
84902208322
-
Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect
-
Sisley S, Gutierrez-Aguilar R, Scott M, et al. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest 2014; 124: 2456-2463.
-
(2014)
J Clin Invest
, vol.124
, pp. 2456-2463
-
-
Sisley, S.1
Gutierrez-Aguilar, R.2
Scott, M.3
-
23
-
-
84856102513
-
GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
-
Alhadeff AL, Rupprecht LE, Hayes MR. GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake. Endocrinology 2012; 153: 647-658.
-
(2012)
Endocrinology
, vol.153
, pp. 647-658
-
-
Alhadeff, A.L.1
Rupprecht, L.E.2
Hayes, M.R.3
-
24
-
-
84900435737
-
Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/kainate signaling
-
Mietlicki-Baase EG, Ortinski PI, Reiner DJ, et al. Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/kainate signaling. J Neurosci 2014; 34: 6985-6992.
-
(2014)
J Neurosci
, vol.34
, pp. 6985-6992
-
-
Mietlicki-Baase, E.G.1
Ortinski, P.I.2
Reiner, D.J.3
-
25
-
-
84904468017
-
Glucagon-like peptide-1 receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake and motivation to feed
-
Alhadeff AL, Baird JP, Swick JC, et al. Glucagon-like peptide-1 receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake and motivation to feed. Neuropsychopharmacology 2014; 39: 2233-2243.
-
(2014)
Neuropsychopharmacology
, vol.39
, pp. 2233-2243
-
-
Alhadeff, A.L.1
Baird, J.P.2
Swick, J.C.3
-
26
-
-
84879189059
-
The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
-
Plamboeck A, Veedfald S, Deacon CF, et al. The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty. Am J Physiol Gastrointest Liver Physiol 2013; 304: G1117-G1127.
-
(2013)
Am J Physiol Gastrointest Liver Physiol
, vol.304
, pp. G1117-G1127
-
-
Plamboeck, A.1
Veedfald, S.2
Deacon, C.F.3
-
27
-
-
0032492893
-
Hypothalamic CART is a new anorectic peptide regulated by leptin
-
Kristensen P, Judge ME, Thim L, et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998; 393: 72-76.
-
(1998)
Nature
, vol.393
, pp. 72-76
-
-
Kristensen, P.1
Judge, M.E.2
Thim, L.3
-
28
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D, et al. Central nervous system control of food intake. Nature 2000; 404: 661-671.
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte, D.3
-
30
-
-
27344431720
-
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
-
Luquet S, Perez FA, Hnasko TS, et al. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 2005; 310: 683-685.
-
(2005)
Science
, vol.310
, pp. 683-685
-
-
Luquet, S.1
Perez, F.A.2
Hnasko, T.S.3
-
31
-
-
84874391991
-
Arcuate AgRP neurons and the regulation of energy balance
-
eCollection 2012.
-
Cansell C, Denis RG, Joly-Amado A, et al. Arcuate AgRP neurons and the regulation of energy balance. Front Endocrinol (Lausanne) 2012; 3: 169 doi: 10.3389/fendo.2012.00169. eCollection 2012.
-
(2012)
Front Endocrinol (Lausanne)
, vol.3
, pp. 169
-
-
Cansell, C.1
Denis, R.G.2
Joly-Amado, A.3
-
32
-
-
84893434815
-
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
-
Balland E, Dam J, Langlet F, et al. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab 2014; 19: 293-301.
-
(2014)
Cell Metab
, vol.19
, pp. 293-301
-
-
Balland, E.1
Dam, J.2
Langlet, F.3
-
33
-
-
0036168190
-
Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
-
Hileman SM, Pierroz DD, Masuzaki H, et al. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002; 143: 775-783.
-
(2002)
Endocrinology
, vol.143
, pp. 775-783
-
-
Hileman, S.M.1
Pierroz, D.D.2
Masuzaki, H.3
-
34
-
-
84872869824
-
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
-
Schaeffer M, Langlet F, Lafont C, et al. Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons. Proc Natl Acad Sci USA 2013; 110: 1512-1517.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 1512-1517
-
-
Schaeffer, M.1
Langlet, F.2
Lafont, C.3
-
35
-
-
84919725884
-
Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain
-
Heppner KM, Kirigiti M, Secher A, et al. Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain. Endocrinology 2015; 156: 255-267.
-
(2015)
Endocrinology
, vol.156
, pp. 255-267
-
-
Heppner, K.M.1
Kirigiti, M.2
Secher, A.3
-
36
-
-
33847072735
-
Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
-
Raun K, von Voss P, Gotfredsen CF, et al. Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not. Diabetes 2007; 56: 8-15.
-
(2007)
Diabetes
, vol.56
, pp. 8-15
-
-
Raun, K.1
von Voss, P.2
Gotfredsen, C.F.3
-
37
-
-
84856880705
-
Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats
-
Hansen G, Jelsing J, Vrang N. Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats. Acta Pharmacol Sin 2012; 33: 194-200.
-
(2012)
Acta Pharmacol Sin
, vol.33
, pp. 194-200
-
-
Hansen, G.1
Jelsing, J.2
Vrang, N.3
-
38
-
-
84860577661
-
Exendin-4 decreases amphetamine-induced locomotor activity
-
Erreger K, Davis AR, Poe AM, et al. Exendin-4 decreases amphetamine-induced locomotor activity. Physiol Behav 2012; 106: 574-578.
-
(2012)
Physiol Behav
, vol.106
, pp. 574-578
-
-
Erreger, K.1
Davis, A.R.2
Poe, A.M.3
-
39
-
-
84899906592
-
Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults
-
Lean ME, Carraro R, Finer N, et al. Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults. Int J Obes (Lond) 2014; 38: 689-697.
-
(2014)
Int J Obes (Lond)
, vol.38
, pp. 689-697
-
-
Lean, M.E.1
Carraro, R.2
Finer, N.3
-
40
-
-
84910070505
-
GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans
-
Van Bloemendaal L, IJzerman RG, Ten Kulve JS, et al. GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans. Diabetes 2014; 63: 4186-4196.
-
(2014)
Diabetes
, vol.63
, pp. 4186-4196
-
-
Van Bloemendaal, L.1
Ijzerman, R.G.2
Ten Kulve, J.S.3
-
41
-
-
84939563219
-
Brain reward-system activation in response to anticipation and consumption of palatable food is altered by GLP-1 receptor activation in humans
-
van Bloemendaal L, Veltman DJ, Ten Kulve JS, et al. Brain reward-system activation in response to anticipation and consumption of palatable food is altered by GLP-1 receptor activation in humans. Diabetes Obes Metab 2015; 17: 878-886.
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 878-886
-
-
van Bloemendaal, L.1
Veltman, D.J.2
Ten Kulve, J.S.3
-
42
-
-
0036198285
-
Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
-
Kastin AJ, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci 2002; 18: 7-14.
-
(2002)
J Mol Neurosci
, vol.18
, pp. 7-14
-
-
Kastin, A.J.1
Akerstrom, V.2
Pan, W.3
-
43
-
-
84858713174
-
Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
-
Hunter K, Holscher C. Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci 2012; 13: 33. doi:10.1186/1471-2202-13-33.
-
(2012)
BMC Neurosci
, vol.13
, pp. 33
-
-
Hunter, K.1
Holscher, C.2
-
44
-
-
0027293254
-
Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension
-
Abernethy WB, Bell MA, Morris M, et al. Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension. Exp Neurol 1993; 121: 270-274.
-
(1993)
Exp Neurol
, vol.121
, pp. 270-274
-
-
Abernethy, W.B.1
Bell, M.A.2
Morris, M.3
-
45
-
-
78650199265
-
The arcuate nucleus as a circumventricular organ in the mouse
-
Ciofi P. The arcuate nucleus as a circumventricular organ in the mouse. Neurosci Lett 2011; 487: 187-190.
-
(2011)
Neurosci Lett
, vol.487
, pp. 187-190
-
-
Ciofi, P.1
-
46
-
-
84881550022
-
Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain
-
Langlet F, Mullier A, Bouret SG, et al. Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain. J Comp Neurol 2013; 521: 3389-3405.
-
(2013)
J Comp Neurol
, vol.521
, pp. 3389-3405
-
-
Langlet, F.1
Mullier, A.2
Bouret, S.G.3
-
47
-
-
84947022827
-
Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes
-
Christensen M, Sparre-Ulrich AH, Hartmann B, et al. Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. Int J Obes (Lond) 2015; 39: 1651-1654.
-
(2015)
Int J Obes (Lond)
, vol.39
, pp. 1651-1654
-
-
Christensen, M.1
Sparre-Ulrich, A.H.2
Hartmann, B.3
|