Concentration-dependent effect of hypocalcaemia on in vitro clot strength in patients at risk of bleeding: A retrospective cohort study

Transfusion Medicine

Volumn 26, Issue 1, 2016, Pages 57-62

  Ho, K M ^a,b,c   Yip, C B ^a  

^a ROYAL PERTH HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c MURDOCH UNIVERSITY   (Australia)

Author keywords

Calcium; Clotting; Coagulopathy; Critical bleeding; Dose response relationship; Haemorrhage

Indexed keywords

CALCIUM ION; FIBRINOGEN; CALCIUM;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOTTING; CALCIUM BLOOD LEVEL; COHORT ANALYSIS; FEMALE; FIBRINOGEN BLOOD LEVEL; HEART SURGERY; HUMAN; HYPOCALCEMIA; HYPOFIBRINOGENEMIA; IN VITRO STUDY; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; RETROSPECTIVE STUDY; RISK FACTOR; STRENGTH; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOELASTOGRAPH; BLOOD; COMPLICATION; HEMORRHAGE; MIDDLE AGED; PROCEDURES;

AGED; CALCIUM; FEMALE; HEMORRHAGE; HUMANS; HYPOCALCEMIA; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84962774330     PISSN: 09587578     EISSN: 13653148     Source Type: Journal    
DOI: 10.1111/tme.12272     Document Type: Article

References (19)

1. Brass, L.F., Zhu, L. & Stalker, T.J. (2005) Minding the gaps to promote thrombus growth and stability. The Journal of Clinical Investigation, 115, 3385-3392.
2. British Committee for Standards in Haematology, Stainsby, D., MacLennan, S., Thomas, D., Isaac, J. & Hamilton, P.J. (2006) Guidelines on the management of massive blood loss. British Journal of Haematology, 135, 634-641.
3. Duff, O.C., Ho, K.M. & Maybrook, S. (2012) In-vitro thrombotic tendency of reactive thrombocytosis in critically ill patients: a prospective case-control study. Anaesthesia and Intensive Care, 40, 472-478.
4. Dzik, W.H. & Kirkley, S.A. (1988) Citrate toxicity during massive blood transfusion. Transfusion Medicine Reviews, 2, 76-94.
5. Gibbs, N.M. (2011) Hypocoagulability, hypercoagulability and the interpretation of 'normal' kaolin-activated thrombelastographs in the perioperative period. Anaesthesia and Intensive Care, 39, 802-803.
6. Guo, Y., Yan, S., Zhang, S., Zhang, X., Chen, Q., Liu, K., Liebeskind, D.S. & Lou, M. (2015) Lower serum calcium level is associated with hemorrhagic transformation after thrombolysis. Stroke, 46, 1359-1361.
7. Hagemo, J.S., Stanworth, S., Juffermans, N.P. et al. (2014) Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Critical Care, 18, R52.
8. Hayes, J.K., Bremer, R.A., Wong, K.C., Jordan, W.S. & Westenskow, D.R. (1980) Continuous monitoring of serum ionized calcium in the dog during sodium citrate infusion using an extracorporeal blood shunt. Canadian Anaesthetists' Society Journal, 27, 458-463.
9. Ho, K.M. & Leonard, A.D. (2011) Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study. Anaesthesia and Intensive Care, 39, 46-54.
10. Ho, K.M., Yip, C.B. & Duff, O. (2012) Reactive thrombocytosis and risk of subsequent venous thromboembolism: a cohort study. Journal of Thrombosis and Haemostasis, 10, 1768-1774.
11. Inoue, Y., Miyashita, F., Toyoda, K. & Minematsu, K. (2013) Low serum calcium levels contribute to larger hematoma volume in acute intracerebral hemorrhage. Stroke, 44, 2004-2006.
12. James, M.F. & Roche, A.M. (2004) Dose-response relationship between plasma ionized calcium concentration and thrombelastography. Journal of Cardiothoracic and Vascular Anesthesia, 18, 581-586.
13. Kauvar, D.S., Holcomb, J.B., Norris, G.C. & Hess, J.R. (2006) Fresh whole blood transfusion: a controversial military practice. The Journal of Trauma, 61, 181-184.
14. Lier, H., Krep, H., Schroeder, S. & Stuber, F. (2008) Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. The Journal of Trauma, 65, 951-960.
15. Magnotti, L.J., Bradburn, E.H., Webb, D.L. et al. (2011) Admission ionized calcium levels predict the need for multiple transfusions: a prospective study of 591 critically ill trauma patients. The Journal of Trauma, 70, 391-395; discussion 395-397.
16. Schilder, L., Nurmohamed, S.A., Bosch, F.H. et al. (2014) Citrate anticoagulation versus systemic heparinisation in continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a multi-center randomized clinical trial. Critical Care, 18, 472.
17. Sihler, K.C. & Napolitano, L.M. (2010) Complications of massive transfusion. Chest, 137, 209-220.
18. Spahn, D.R., Bouillon, B., Cerny, V. et al. (2013) Management of bleeding and coagulopathy following major trauma: an updated European guideline. Critical Care, 17, R76.
19. Vivien, B., Langeron, O., Morell, E., Devilliers, C., Carli, P.A., Coriat, P. & Riou, B. (2005) Early hypocalcemia in severe trauma. Critical Care Medicine, 33, 1946-1952.