Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 11, 2016, Pages 2851-2856

  Woo, Christina M ^a   Li, Zhenwu ^a   Paulson, Eric K ^a   Herzon, Seth B ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA; Double strand break; Natural product; NMR

Indexed keywords

ANTINEOPLASTIC AGENT; DOUBLE STRANDED DNA; HYDROGEN; KINAMYCIN; LOMAIVITICIN A; LOMAIVITICIN B; LOMAIVITICIN C; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CALF THYMUS DNA; DNA; FLUORENE DERIVATIVE; HETERODUPLEX;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BASE PAIRING; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DNA BINDING; DNA CLEAVAGE; DNA STRAND; DRUG POTENCY; DRUG STRUCTURE; MICROCOCCUS; MICROCOCCUS LYSODEIKTIUS; PRIORITY JOURNAL; CHEMISTRY; CONFORMATION; FLUORESCENCE; GENETICS; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTIBIOTICS, ANTINEOPLASTIC; DNA; DNA CLEAVAGE; FLUORENES; FLUORESCENCE; MAGNETIC RESONANCE SPECTROSCOPY; MICROCOCCUS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES;

EID: 84962584081     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519846113     Document Type: Article

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