Association of opioids and sedatives with increased risk of in-hospital cardiopulmonary arrest from an administrative database

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Overdyk, Frank J ^a,b   Dowling, Oonagh ^a   Marino, Joseph ^a,b   Qiu, Jiejing ^c   Chien, Hung Lun ^c   Erslon, Mary ^d   Morrison, Neil ^e   Harrison, Brooke ^f   Dahan, Albert ^g   Gan, Tong J ^h  

^a DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^b North American Partners in Anesthesia (NAPA)   (United States)

^c MEDTRONIC INC   (United States)

^d Covidien Respiratory and Monitoring Solutions ^*  (United States)

^e Harrier Consultancy   (United Kingdom)

^f Boulder Medical Writing   (United States)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NARCOTIC ANALGESIC AGENT; SEDATIVE AGENT; HYPNOTIC SEDATIVE AGENT;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CARDIOPULMONARY ARREST; CONTROLLED STUDY; DATA BASE; FEMALE; HEALTH CARE COST; HIGH RISK PATIENT; HOSPITAL DISCHARGE; HOSPITAL PATIENT; HUMAN; INCIDENCE; LENGTH OF STAY; LOW RISK PATIENT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT MONITORING; PREVALENCE; RETROSPECTIVE STUDY; RISK ASSESSMENT; ADVERSE EFFECTS; ANALGESIA; CHEMICALLY INDUCED; COST OF ILLNESS; ECONOMICS; FACTUAL DATABASE; HEART ARREST; HOSPITALIZATION; MEDICAL RECORD; MIDDLE AGED; PROCEDURES; RESUSCITATION; RISK; RISK FACTOR; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANALGESIA; ANALGESICS, OPIOID; CARDIOPULMONARY RESUSCITATION; COST OF ILLNESS; DATABASES, FACTUAL; FEMALE; HEART ARREST; HOSPITAL RECORDS; HOSPITALIZATION; HUMANS; HYPNOTICS AND SEDATIVES; LENGTH OF STAY; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK; RISK FACTORS; YOUNG ADULT;

EID: 84962538637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150214     Document Type: Article

References (38)

1. Kohn LT, Corrigan JM, Donaldson MS, editors. To err is human: building a safer health system: National Academy Press, Institute of Medicine; 1999
2. Morrison LJ, Neumar RW, Zimmerman JL, Link MS, Newby LK, McMullan PW Jr., et al. Strategies for improving survival after in-hospital cardiac arrest in the United States: 2013 consensus recommendations: a consensus statement from the American Heart Association. Circulation. 2013;127(14):1538-63. doi: 10.1161/CIR.0b013e31828b2770 PMID: 23479672.
3. Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS, et al. Trends in survival after inhospital cardiac arrest. N Engl J Med. 2012;367(20):1912-20. doi: 10.1056/NEJMoa1109148 PMID: 23150959; PubMed Central PMCID: PMC3517894.
4. Ebell MH, Jang W, Shen Y, Geocadin RG, Get With the Guidelines-Resuscitation I. Development and validation of the Good Outcome Following Attempted Resuscitation (GO-FAR) score to predict neurologically intact survival after in-hospital cardiopulmonary resuscitation. JAMA Intern Med. 2013;173(20):1872-8. doi: 10.1001/jamainternmed.2013.10037 PMID: 24018585.
5. Hillman K, Chen J, Cretikos M, Bellomo R, Brown D, Doig G, et al. Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet. 2005;365(9477):2091-7. doi: 10.1016/S0140-6736 (05) 66733-5 PMID: 15964445.
6. Chan PS, Khalid A, Longmore LS, Berg RA, Kosiborod M, Spertus JA. Hospital-wide code rates and mortality before and after implementation of a rapid response team. JAMA. 2008;300(21):2506-13. doi: 10.1001/jama.2008.715 PMID: 19050194.
7. Jarzyna D, Jungquist CR, Pasero C, Willens JS, Nisbet A, Oakes L, et al. American Society for Pain Management Nursing guidelines on monitoring for opioid-induced sedation and respiratory depression. Pain Manag Nurs. 2011;12(3):118-45e10. doi: 10.1016/j.pmn. 2011.06.008 PMID: 21893302.
8. Parsells Kelly J, Cook SF, Kaufman DW, Anderson T, Rosenberg L, Mitchell AA. Prevalence and characteristics of opioid use in the US adult population. Pain. 2008;138(3):507-13. doi: 10.1016/j.pain. 2008.01.027 PMID: 18342447.
9. Sullivan MD, Edlund MJ, Fan MY, Devries A, Brennan Braden J, Martin BC. Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and Medicaid insurance plans: the TROUP study. Pain. 2008;138(2):440-9. doi: 10.1016/j.pain. 2008.04.027 PMID: 18547726; PubMed Central PMCID: PMC2668925.
10. Zerzan JT, Morden NE, Soumerai S, Ross-Degnan D, Roughead E, Zhang F, et al. Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996 to 2002. Med Care. 2006;44(11):1005-10. doi: 10.1097/01.mlr.0000228025.04535.25 PMID: 17063132.
11. Oderda GM, Said Q, Evans RS, Stoddard GJ, Lloyd J, Jackson K, et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Ann Pharmacother. 2007;41(3):400-6. doi: 10.1345/aph.1H386 PMID: 17341537.
12. Davies EC, Green CF, Taylor S, Williamson PR, Mottram DR, Pirmohamed M. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One. 2009;4(2):e4439. doi: 10.1371/journal.pone.0004439 PMID: 19209224; PubMed Central PMCID: PMC2635959.
13. Dahan A, Aarts L, Smith TW. Incidence, reversal, and prevention of opioid-induced respiratory depression. Anesthesiology. 2010;112(1):226-38. doi: 10.1097/ALN.0b013e3181c38c25 PMID: 20010421.
14. Oderda GM, Gan TJ, Johnson BH, Robinson SB. Effect of opioid-related adverse events on outcomes in selected surgical patients. J Pain PalliatCare Pharmacother. 2013;27(1):62-70. doi: 10.3109/15360288.2012.751956 PMID: 23302094.
15. The Joint Commission. Safe use of opioids in hospitals. Sentinel Event Alert 2012. http://www.jointcommission.org/sea issue 49/. PMID: 22888503
16. Lee LA, Caplan RA, Stephens LS, Posner KL, Terman GW, Voepel-Lewis T, et al. Postoperative opioid-induced respiratory depression: a closed claims analysis. Anesthesiology. 2015;122(3):659-65. doi: 10.1097/ALN.0000000000000564 PMID: 25536092.
17. Herzig SJ, Rothberg MB, Cheung M, Ngo LH, Marcantonio ER. Opioid utilization and opioid-related adverse events in nonsurgical patients in US hospitals. J Hosp Med. 2014;9(2):73-81. doi: 10.1002/jhm.2102 PMID: 24227700; PubMed Central PMCID: PMC3976956.
18. Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH. Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology. 1990;73(5):826-30. PMID: 2122773.
19. Giummarra MJ, Gibson SJ, Allen AR, Pichler AS, Arnold CA. Polypharmacy and chronic pain: harm exposure is not all about the opioids. Pain Medicine. 2014.
20. Howington JA, Gunnarsson CL, Maddaus MA, McKenna RJ, Meyers BF, Miller D, et al. In-hospital clinical and economic consequences of pulmonary wedge resections for cancer using video-assisted thoracoscopic techniques vs traditional open resections: a retrospective database analysis. Chest. 2012;141(2):429-35. doi: 10.1378/chest.10-3013 PMID: 21778260.
21. Lindenauer PK, Pekow P, Wang K, Mamidi DK, Gutierrez B, Benjamin EM. Perioperative beta-blocker therapy and mortality after major noncardiac surgery. N Engl J Med. 2005;353(4):349-61. doi: 10. 1056/NEJMoa041895 PMID: 16049209.
22. Lindenauer PK, Stefan MS, Shieh MS, Pekow PS, Rothberg MB, Hill NS. Outcomes associated with invasive and noninvasive ventilation among patients hospitalized with exacerbations of chronic obstructive pulmonary disease. JAMA Intern Med. 2014;174(12):1982-93. doi: 10.1001/jamainternmed.2014.5430 PMID: 25347545.
23. Merchant RM, Yang L, Becker LB, Berg RA, Nadkarni V, Nichol G, et al. Incidence of treated cardiac arrest in hospitalized patients in the United States. CritCare Med. 2011;39(11):2401-6. doi: 10.1097/CCM.0b013e3182257459 PMID: 21705896; PubMed Central PMCID: PMC3196742.
24. Peberdy MA, Kaye W, Ornato JP, Larkin GL, Nadkarni V, Mancini ME, et al. Cardiopulmonary resuscitation of adults in the hospital: a report of 14720 cardiac arrests from the National Registry of Cardiopulmonary Resuscitation. Resuscitation. 2003;58(3):297-308. PMID: 12969608.
25. Ehlenbach WJ, Barnato AE, Curtis JR, Kreuter W, Koepsell TD, Deyo RA, et al. Epidemiologic study of in-hospital cardiopulmonary resuscitation in the elderly. N Engl J Med. 2009;361(1):22-31. doi: 10. 1056/NEJMoa0810245 PMID: 19571280; PubMed Central PMCID: PMC2917337.
26. Sandroni C, Nolan J, Cavallaro F, Antonelli M. In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival. Intensive Care Med. 2007;33(2):237-45. doi: 10.1007/s00134-006-0326-z PMID: 17019558.
27. Larkin GL, Copes WS, Nathanson BH, Kaye W. Pre-resuscitation factors associated with mortality in 49, 130 cases of in-hospital cardiac arrest: a report from the National Registry for Cardiopulmonary Resuscitation. Resuscitation. 2010;81(3):302-11. doi: 10.1016/j.resuscitation. 2009.11.021 PMID: 20047786.
28. Chan PS, Nichol G, Krumholz HM, Spertus JA, Jones PG, Peterson ED, et al. Racial differences in survival after in-hospital cardiac arrest. JAMA. 2009;302(11):1195-201. doi: 10.1001/jama.2009.1340 PMID: 19755698; PubMed Central PMCID: PMC2795316.
29. Reed K, May R. HealthGrades Patient Safety in American Hospitals Study. http://www.healthgrades. com. 2011.
30. Hillman KM, Bristow PJ, Chey T, Daffurn K, Jacques T, Norman SL, et al. Antecedents to hospital deaths. Intern Med J. 2001;31(6):343-8. PMID: 11529588.
31. Chan PS, Jain R, Nallmothu BK, Berg RA, Sasson C. Rapid response teams: a systematic review and meta-analysis. Arch Intern Med. 2010;170(1):18-26. doi: 10.1001/archinternmed.2009.424 PMID: 20065195.
32. Galhotra S, De Vita MA, Simmons RL, Dew MA, Members of the Medical Emergency Response Improvement Team C. Mature rapid response system and potentially avoidable cardiopulmonary arrests in hospital. Qual Saf Health Care. 2007;16(4):260-5. doi: 10.1136/qshc.2007.022210 PMID: 17693672; PubMed Central PMCID: PMC2464936.
33. Devita MA, Bellomo R, Hillman K, Kellum J, Rotondi A, Teres D, et al. Findings of the first consensus conference on medical emergency teams. CritCare Med. 2006;34(9):2463-78. doi: 10.1097/01. CCM. 0000235743.38172.6E PMID: 16878033.
34. Sun Z, Sessler DI, Dalton JE, Devereaux PJ, Shahinyan A, Naylor AJ, et al. Postoperative hypoxemia is common and persistent: a prospective blinded observational study. Anesth Analg. 2015;121(3):709-15. doi: 10.1213/ANE.0000000000000836 PMID: 26287299.
35. Chen J, Hillman K, Bellomo R, Flabouris A, Finfer S, Cretikos M, et al. The impact of introducing medical emergency team system on the documentations of vital signs. Resuscitation. 2009;80(1):35-43. doi: 10.1016/j.resuscitation. 2008.10.009 PMID: 19010579.
36. Taenzer AH, Pyke JB, McGrath SP, Blike GT. Impact of pulse oximetry surveillance on rescue events and intensive care unit transfers: a before-and-after concurrence study. Anesthesiology. 2010;112(2):282-7. doi: 10.1097/ALN.0b013e3181ca7a9b PMID: 20098128.
37. https://www.cms.gov/Medicare/Provider-Enrollment-and-Certification/SurveyCertificationGenInfo/Downloads/Survey-and-Cert-Letter-14-15.pdf.
38. Peberdy MA, Callaway CW, Neumar RW, Geocadin RG, Zimmerman JL, Donnino M, et al. Part9: postcardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010;122(18 Suppl 3):S768-86. doi: 10.1161/CIRCULATIONAHA.110.971002 PMID: 20956225.