Inferring the effects of cancer treatment: Divergent Results from Early Breast Cancer Trialists' Collaborative Group meta-analyses of randomized trials and observational data from SEER registries

Journal of Clinical Oncology

Volumn 34, Issue 8, 2016, Pages 803-809

  Henson, Katherine E ^a   Jagsi, Reshma ^b   Cutter, David ^a   McGale, Paul ^a   Taylor, Carolyn ^a   Darby, Sarah C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER REGISTRY; DATA ANALYSIS; HUMAN; LYMPH NODE METASTASIS; META ANALYSIS; OBSERVATIONAL STUDY; PARTIAL MASTECTOMY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); ADJUVANT RADIOTHERAPY; BREAST NEOPLASMS; COMPARATIVE STUDY; FEMALE; MORTALITY; RETRACTED ARTICLE; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

BREAST NEOPLASMS; FEMALE; HUMANS; MASTECTOMY, SEGMENTAL; OBSERVATIONAL STUDIES AS TOPIC; RADIOTHERAPY, ADJUVANT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEER PROGRAM; TREATMENT OUTCOME;

EID: 84962496170     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2015.62.0294     Document Type: Article

References (18)

1. Institute of Medicine. A national cancer clinical trials system for the 21st century: Reinvigorating the NCI Cooperative Group Program. Washington, DC, The National Academies Press, 2010
2. Chakma J, Sun GH, Steinberg JD, et al: Asia's ascent-Global trends in biomedical R&D expenditures. N Engl J Med 370:3-6, 2014
3. Meyer A-M, Wheeler SB, Weinberger M, et al: An overview of methods for comparative effectiveness research. Semin Radiat Oncol 24:5-13, 2014
4. Korn EL, Freidlin B: Methodology for comparative effectiveness research: Potential and limitations. J Clin Oncol 30:4185-4187, 2012
5. Lyman GH, Levine M: Comparative effectiveness research in oncology: An overview. J Clin Oncol 30:4181-4184, 2012
6. Jagsi R, Abrahamse P, Morrow M, et al: Patterns and correlates of adjuvant radiotherapy receipt after lumpectomy and after mastectomy for breast cancer. J Clin Oncol 28:2396-2403, 2010
7. Early Breast Cancer Trialists' Collaborative Group: Favourable and unfavourable effects on longterm survival of radiotherapy for early breast cancer: An overview of the randomised trials. Lancet 355:1757-1770, 2000
8. Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet 366:2087-2106, 2005
9. Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effect of radiotherapy after breastconserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10, 801 women in 17 randomised trials. Lancet 378:1707-1716, 2011
10. Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: Meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 383:2127-2135, 2014
11. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Treatment of Early Breast Cancer. Volume 1. Worldwide Evidence 1985-90. Oxford, United Kingdom, Oxford University Press, 1990. http://www.ctsu.ox.ac.uk/ebctcg/methods
12. National Cancer Institute DCCPS Surveillance Research Program Cancer Statistics Branch: (released January 2011). Surveillance, Epidemiology and End Results (SEER) Program [www.seer.cancer.gov Research Data (1973-2008)]
13. StataCorp. Stata Statistical Software: Release
14. College Station, TX, StataCorp LP, 2011
15. Soulos PR, Yu JB, Roberts KB, et al: Assessing the impact of a cooperative group trial on breast cancer care in the Medicare population. J Clin Oncol 30:1601-1607, 2012
16. National Comprehensive Cancer Center Network (NCCN) Clinical Practice Guidelines in Oncology: Breast Cancer V.3.2012. http://www.nccn.org/professionals/physician-gls/f-guidelines.asp.
17. Giordano SH, Kuo YF, Duan Z, et al: Limits of observational data in determining outcomes from cancer therapy. Cancer 112:2456-2466, 2008
18. Vandenbroucke JP: When are observational studies as credible as randomised trials? Lancet 363:1728-1731, 2004