-
1
-
-
0032433127
-
The central role of CD4 (+) T cells in the antitumor immune response
-
Hung, K., R. Hayashi, A. Lafond-Walker, C. Lowenstein, D. Pardoll, and H. Levitsky. 1998. The central role of CD4 (+) T cells in the antitumor immune response. J. Exp. Med. 188:2357-2368.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2357-2368
-
-
Hung, K.1
Hayashi, R.2
Lafond-Walker, A.3
Lowenstein, C.4
Pardoll, D.5
Levitsky, H.6
-
2
-
-
79952093380
-
Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
-
Mlecnik, B., M. Tosolini, A. Kirilovsky, A. Berger, G. Bindea, T. Meatchi, P. Bruneval, Z. Trajanoski, W. H. Fridman, F. Pagès, and J. Galon. 2011. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J. Clin. Oncol. 29:610-618.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 610-618
-
-
Mlecnik, B.1
Tosolini, M.2
Kirilovsky, A.3
Berger, A.4
Bindea, G.5
Meatchi, T.6
Bruneval, P.7
Trajanoski, Z.8
Fridman, W.H.9
Pagès, F.10
Galon, J.11
-
3
-
-
66149156276
-
+ T-cell recruitment
-
+ T-cell recruitment. Cancer Res. 69:3077-3085.
-
(2009)
Cancer Res.
, vol.69
, pp. 3077-3085
-
-
Harlin, H.1
Meng, Y.2
Peterson, A.C.3
Zha, Y.4
Tretiakova, M.5
Slingluff, C.6
McKee, M.7
Gajewski, T.F.8
-
4
-
-
84880720167
-
Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy
-
Ulloa-Montoya, F., J. Louahed, B. Dizier, O. Gruselle, B. Spiessens, F. F. Lehmann, S. Suciu, W. H. Kruit, A. M. Eggermont, J. Vansteenkiste, and V. G. Brichard. 2013. Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy. J. Clin. Oncol. 31:2388-2395.
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 2388-2395
-
-
Ulloa-Montoya, F.1
Louahed, J.2
Dizier, B.3
Gruselle, O.4
Spiessens, B.5
Lehmann, F.F.6
Suciu, S.7
Kruit, W.H.8
Eggermont, A.M.9
Vansteenkiste, J.10
Brichard, V.G.11
-
5
-
-
0037448353
-
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
-
Zhang, L., J. R. Conejo-Garcia, D. Katsaros, P. A. Gimotty, M. Massobrio, G. Regnani, A. Makrigiannakis, H. Gray, K. Schlienger, M. N. Liebman, et al. 2003. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348:203-213.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 203-213
-
-
Zhang, L.1
Conejo-Garcia, J.R.2
Katsaros, D.3
Gimotty, P.A.4
Massobrio, M.5
Regnani, G.6
Makrigiannakis, A.7
Gray, H.8
Schlienger, K.9
Liebman, M.N.10
-
6
-
-
4344671644
-
Effector function of human tumor-specific CD8 T cells in melanoma lesions: A state of local functional tolerance
-
Zippelius, A., P. Batard, V. Rubio-Godoy, G. Bioley, D. Liénard, F. Lejeune, D. Rimoldi, P. Guillaume, N. Meidenbauer, A. Mackensen, et al. 2004. Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res. 64:2865-2873.
-
(2004)
Cancer Res.
, vol.64
, pp. 2865-2873
-
-
Zippelius, A.1
Batard, P.2
Rubio-Godoy, V.3
Bioley, G.4
Liénard, D.5
Lejeune, F.6
Rimoldi, D.7
Guillaume, P.8
Meidenbauer, N.9
Mackensen, A.10
-
7
-
-
33746214819
-
+ T cells in the circulation but not in the tumor site
-
+ T cells in the circulation but not in the tumor site. J. Immunol. 177:1670-1678.
-
(2006)
J. Immunol.
, vol.177
, pp. 1670-1678
-
-
Appay, V.1
Jandus, C.2
Voelter, V.3
Reynard, S.4
Coupland, S.E.5
Rimoldi, D.6
Lienard, D.7
Guillaume, P.8
Krieg, A.M.9
Cerottini, J.C.10
-
8
-
-
0038181111
-
+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma
-
+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma. Cancer Res. 63:2535-2545.
-
(2003)
Cancer Res.
, vol.63
, pp. 2535-2545
-
-
Mortarini, R.1
Piris, A.2
Maurichi, A.3
Molla, A.4
Bersani, I.5
Bono, A.6
Bartoli, C.7
Santinami, M.8
Lombardo, C.9
Ravagnani, F.10
-
9
-
-
33745632047
-
Tumor progression despite massive influx of activated CD8 (+) T cells in a patient with malignant melanoma ascites
-
Harlin, H., T. V. Kuna, A. C. Peterson, Y. Meng, and T. F. Gajewski. 2006. Tumor progression despite massive influx of activated CD8 (+) T cells in a patient with malignant melanoma ascites. Cancer Immunol. Immunother. 55:1185-1197.
-
(2006)
Cancer Immunol. Immunother.
, vol.55
, pp. 1185-1197
-
-
Harlin, H.1
Kuna, T.V.2
Peterson, A.C.3
Meng, Y.4
Gajewski, T.F.5
-
10
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F. S., S. J. O'Day, D. F. McDermott, R. W. Weber, J. A. Sosman, J. B. Haanen, R. Gonzalez, C. Robert, D. Schadendorf, J. C. Hassel, et al. 2010. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363:711-723.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
-
11
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach, D. R., M. F. Krummel, and J. P. Allison. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734-1736.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
12
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid, O., C. Robert, A. Daud, F. S. Hodi, W.-J. Hwu, R. Kefford, J. D. Wolchok, P. Hersey, R. W. Joseph, J. S. Weber, et al. 2013. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369:134-144.
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.-J.5
Kefford, R.6
Wolchok, J.D.7
Hersey, P.8
Joseph, R.W.9
Weber, J.S.10
-
13
-
-
0032696676
-
Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells
-
Uzzo, R. G., P. Rayman, V. Kolenko, P. E. Clark, M. K. Cathcart, T. Bloom, A. C. Novick, R. M. Bukowski, T. Hamilton, and J. H. Finke. 1999. Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells. J. Clin. Invest. 104:769-776.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 769-776
-
-
Uzzo, R.G.1
Rayman, P.2
Kolenko, V.3
Clark, P.E.4
Cathcart, M.K.5
Bloom, T.6
Novick, A.C.7
Bukowski, R.M.8
Hamilton, T.9
Finke, J.H.10
-
14
-
-
84880147469
-
Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-kB and NFAT signaling in tumor-associated T cells
-
Simpson-Abelson, M. R., J. L. Loyall, H. K. Lehman, J. L. Barnas, H. Minderman, K. L. O'Loughlin, P. K. Wallace, T. C. George, P. Peng, R. J. Kelleher, Jr., et al. 2013. Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-kB and NFAT signaling in tumor-associated T cells. Cancer Immun. 13:14.
-
(2013)
Cancer Immun.
, vol.13
, pp. 14
-
-
Simpson-Abelson, M.R.1
Loyall, J.L.2
Lehman, H.K.3
Barnas, J.L.4
Minderman, H.5
O'Loughlin, K.L.6
Wallace, P.K.7
George, T.C.8
Peng, P.9
Kelleher, R.J.10
-
15
-
-
0033590799
-
Alterations in NFkappaB activation in T lymphocytes of patients with renal cell carcinoma
-
Uzzo, R. G., P. E. Clark, P. Rayman, T. Bloom, L. Rybicki, A. C. Novick, R. M. Bukowski, and J. H. Finke. 1999. Alterations in NFkappaB activation in T lymphocytes of patients with renal cell carcinoma. J. Natl. Cancer Inst. 91:718-721.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 718-721
-
-
Uzzo, R.G.1
Clark, P.E.2
Rayman, P.3
Bloom, T.4
Rybicki, L.5
Novick, A.C.6
Bukowski, R.M.7
Finke, J.H.8
-
16
-
-
32044452015
-
IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells
-
Broderick, L., S. P. Brooks, H. Takita, A. N. Baer, J. M. Bernstein, and R. B. Bankert. 2006. IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells. Clin. Immunol. 118:159-169.
-
(2006)
Clin. Immunol.
, vol.118
, pp. 159-169
-
-
Broderick, L.1
Brooks, S.P.2
Takita, H.3
Baer, A.N.4
Bernstein, J.M.5
Bankert, R.B.6
-
17
-
-
84977079216
-
T cell-NF-kB activation is required for tumor control in vivo
-
Barnes, S. E., Y. Wang, L. Chen, L. L. Molinero, T. F. Gajewski, C. Evaristo, and M.-L. Alegre. 2015. T cell-NF-kB activation is required for tumor control in vivo. J. Immunother. Cancer 3:1.
-
(2015)
J. Immunother. Cancer
, vol.3
, pp. 1
-
-
Barnes, S.E.1
Wang, Y.2
Chen, L.3
Molinero, L.L.4
Gajewski, T.F.5
Evaristo, C.6
Alegre, M.-L.7
-
18
-
-
0034610322
-
Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells
-
Wan, Y. Y., R. P. Leon, R. Marks, C. M. Cham, J. Schaack, T. F. Gajewski, and J. De Gregori. 2000. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc. Natl. Acad. Sci. USA 97:13784-13789.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13784-13789
-
-
Wan, Y.Y.1
Leon, R.P.2
Marks, R.3
Cham, C.M.4
Schaack, J.5
Gajewski, T.F.6
De Gregori, J.7
-
19
-
-
33846470670
-
Controlled expression of transgenes introduced by in vivo electroporation
-
Matsuda, T., and C. L. Cepko. 2007. Controlled expression of transgenes introduced by in vivo electroporation. Proc. Natl. Acad. Sci. USA 104:1027-1032.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 1027-1032
-
-
Matsuda, T.1
Cepko, C.L.2
-
20
-
-
0036911269
-
Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells
-
Spiotto, M. T., P. Yu, D. A. Rowley, M. I. Nishimura, S. C. Meredith, T. F. Gajewski, Y. X. Fu, and H. Schreiber. 2002. Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity 17:737-747.
-
(2002)
Immunity
, vol.17
, pp. 737-747
-
-
Spiotto, M.T.1
Yu, P.2
Rowley, D.A.3
Nishimura, M.I.4
Meredith, S.C.5
Gajewski, T.F.6
Fu, Y.X.7
Schreiber, H.8
-
21
-
-
33846048039
-
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
-
Vilimas, T., J. Mascarenhas, T. Palomero, M. Mandal, S. Buonamici, F. Meng, B. Thompson, C. Spaulding, S. Macaroun, M.-L. Alegre, et al. 2007. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat. Med. 13:70-77.
-
(2007)
Nat. Med.
, vol.13
, pp. 70-77
-
-
Vilimas, T.1
Mascarenhas, J.2
Palomero, T.3
Mandal, M.4
Buonamici, S.5
Meng, F.6
Thompson, B.7
Spaulding, C.8
Macaroun, S.9
Alegre, M.-L.10
-
22
-
-
0043269706
-
Retroviral vectors for high-level transgene expression in T lymphocytes
-
Engels, B., H. Cam, T. Schüler, S. Indraccolo, M. Gladow, C. Baum, T. Blankenstein, and W. Uckert. 2003. Retroviral vectors for high-level transgene expression in T lymphocytes. Hum. Gene Ther. 14:1155-1168.
-
(2003)
Hum. Gene Ther.
, vol.14
, pp. 1155-1168
-
-
Engels, B.1
Cam, H.2
Schüler, T.3
Indraccolo, S.4
Gladow, M.5
Baum, C.6
Blankenstein, T.7
Uckert, W.8
-
23
-
-
0031157453
-
Sequential development of structural and functional alterations in T cells from tumor-bearing mice
-
Correa, M. R., A. C. Ochoa, P. Ghosh, H. Mizoguchi, L. Harvey, and D. L. Longo. 1997. Sequential development of structural and functional alterations in T cells from tumor-bearing mice. J. Immunol. 158:5292-5296.
-
(1997)
J. Immunol.
, vol.158
, pp. 5292-5296
-
-
Correa, M.R.1
Ochoa, A.C.2
Ghosh, P.3
Mizoguchi, H.4
Harvey, L.5
Longo, D.L.6
-
24
-
-
0028176728
-
Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy
-
Ghosh, P., A. Sica, H. A. Young, J. Ye, J. L. Franco, R. H. Wiltrout, D. L. Longo, N. R. Rice, and K. L. Komschlies. 1994. Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy. Cancer Res. 54:2969-2972.
-
(1994)
Cancer Res.
, vol.54
, pp. 2969-2972
-
-
Ghosh, P.1
Sica, A.2
Young, H.A.3
Ye, J.4
Franco, J.L.5
Wiltrout, R.H.6
Longo, D.L.7
Rice, N.R.8
Komschlies, K.L.9
-
25
-
-
79955021405
-
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-kB-dependent manner
-
Molinero, L. L., M. L. Miller, C. Evaristo, and M. L. Alegre. 2011. High TCR stimuli prevent induced regulatory T cell differentiation in a NF-kB-dependent manner. J. Immunol. 186:4609-4617.
-
(2011)
J. Immunol.
, vol.186
, pp. 4609-4617
-
-
Molinero, L.L.1
Miller, M.L.2
Evaristo, C.3
Alegre, M.L.4
-
26
-
-
23844446653
-
Interferongamma and cancer immunoediting
-
Dunn, G. P., H. Ikeda, A. T. Bruce, C. Koebel, R. Uppaluri, J. Bui, R. Chan, M. Diamond, J. M. White, K. C. Sheehan, and R. D. Schreiber. 2005. Interferongamma and cancer immunoediting. Immunol. Res. 32:231-245.
-
(2005)
Immunol. Res.
, vol.32
, pp. 231-245
-
-
Dunn, G.P.1
Ikeda, H.2
Bruce, A.T.3
Koebel, C.4
Uppaluri, R.5
Bui, J.6
Chan, R.7
Diamond, M.8
White, J.M.9
Sheehan, K.C.10
Schreiber, R.D.11
-
27
-
-
84863275160
-
Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation
-
Kline, J., L. Zhang, L. Battaglia, K. S. Cohen, and T. F. Gajewski. 2012. Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J. Immunol. 188:2630-2642.
-
(2012)
J. Immunol.
, vol.188
, pp. 2630-2642
-
-
Kline, J.1
Zhang, L.2
Battaglia, L.3
Cohen, K.S.4
Gajewski, T.F.5
-
28
-
-
18244365863
-
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
Lee, P. P., D. R. Fitzpatrick, C. Beard, H. K. Jessup, S. Lehar, K. W. Makar, M. Pérez-Melgosa, M. T. Sweetser, M. S. Schlissel, S. Nguyen, et al. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15:763-774.
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
Fitzpatrick, D.R.2
Beard, C.3
Jessup, H.K.4
Lehar, S.5
Makar, K.W.6
Pérez-Melgosa, M.7
Sweetser, M.T.8
Schlissel, M.S.9
Nguyen, S.10
-
29
-
-
84864144782
-
Chronic activation of the kinase IKKb impairs T cell function and survival
-
Krishna, S., D. Xie, B. Gorentla, J. Shin, J. Gao, and X. P. Zhong. 2012. Chronic activation of the kinase IKKb impairs T cell function and survival. J. Immunol. 189:1209-1219.
-
(2012)
J. Immunol.
, vol.189
, pp. 1209-1219
-
-
Krishna, S.1
Xie, D.2
Gorentla, B.3
Shin, J.4
Gao, J.5
Zhong, X.P.6
-
30
-
-
11144357466
-
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
-
Hu, M. C., D.-F. Lee, W. Xia, L. S. Golfman, F. Ou-Yang, J.-Y. Yang, Y. Zou, S. Bao, N. Hanada, H. Saso, et al. 2004. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117:225-237.
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
Lee, D.-F.2
Xia, W.3
Golfman, L.S.4
Ou-Yang, F.5
Yang, J.-Y.6
Zou, Y.7
Bao, S.8
Hanada, N.9
Saso, H.10
-
31
-
-
40749090052
-
IkappaB kinase b (IKKbeta/IKK2/IKBKB)-a key molecule in signaling to the transcription factor NF-kappaB
-
Schmid, J. A., and A. Birbach. 2008. IkappaB kinase b (IKKbeta/IKK2/IKBKB)-a key molecule in signaling to the transcription factor NF-kappaB. Cytokine Growth Factor Rev. 19:157-165.
-
(2008)
Cytokine Growth Factor Rev.
, vol.19
, pp. 157-165
-
-
Schmid, J.A.1
Birbach, A.2
-
32
-
-
84929386544
-
Clinical deployment of antibodies for treatment of melanoma
-
Curti, B. D., and W. J. Urba. 2015. Clinical deployment of antibodies for treatment of melanoma. Mol. Immunol. 67(2 Pt. A):18-27.
-
(2015)
Mol. Immunol.
, vol.67
, Issue.2
, pp. 18-27
-
-
Curti, B.D.1
Urba, W.J.2
-
33
-
-
36649015604
-
Overexpression of program death-1 in T cells has mild impact on allograft survival
-
Chen, L., Y. Hussien, K. W. Hwang, Y. Wang, P. Zhou, and M. L. Alegre. 2008. Overexpression of program death-1 in T cells has mild impact on allograft survival. Transpl. Int. 21:21-29.
-
(2008)
Transpl. Int.
, vol.21
, pp. 21-29
-
-
Chen, L.1
Hussien, Y.2
Hwang, K.W.3
Wang, Y.4
Zhou, P.5
Alegre, M.L.6
-
34
-
-
0036687077
-
CTLA-4 engagement regulates NF-kappaB activation in vivo
-
Harlin, H., K. W. Hwang, D. A. Palucki, O. Kim, C. B. Thompson, M. Boothby, and M. L. Alegre. 2002. CTLA-4 engagement regulates NF-kappaB activation in vivo. Eur. J. Immunol. 32:2095-2104.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 2095-2104
-
-
Harlin, H.1
Hwang, K.W.2
Palucki, D.A.3
Kim, O.4
Thompson, C.B.5
Boothby, M.6
Alegre, M.L.7
-
35
-
-
84879084285
-
T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes
-
Martinez-Forero, I., A. Azpilikueta, E. Bolaños-Mateo, E. Nistal-Villan, A. Palazon, A. Teijeira, G. Perez-Chacon, A. Morales-Kastresana, O. Murillo, M. Jure-Kunkel, et al. 2013. T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes. J. Immunol. 190:6694-6706.
-
(2013)
J. Immunol.
, vol.190
, pp. 6694-6706
-
-
Martinez-Forero, I.1
Azpilikueta, A.2
Bolaños-Mateo, E.3
Nistal-Villan, E.4
Palazon, A.5
Teijeira, A.6
Perez-Chacon, G.7
Morales-Kastresana, A.8
Murillo, O.9
Jure-Kunkel, M.10
-
36
-
-
84860427686
-
Cancer immunotherapy
-
Gajewski, T. F. 2012. Cancer immunotherapy. Mol. Oncol. 6:242-250.
-
(2012)
Mol. Oncol.
, vol.6
, pp. 242-250
-
-
Gajewski, T.F.1
|