Remission of severe neonatal diabetes with very early sulfonylurea treatment

Diabetes Care

Volumn 38, Issue 3, 2015, Pages e38-e39

  Marshall, Bess A ^a   Green, Rebecca P ^b   Wambach, Jennifer ^a   White, Neil H ^a   Remedi, Maria S ^a   Nichols, Colin G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Springfield Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIBENCLAMIDE; HEMOGLOBIN A1C; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; ANTIDIABETIC AGENT; SULFONYLUREA DERIVATIVE;

CASE REPORT; CHILD; DRUG MEGADOSE; DRUG WITHDRAWAL; EARLY INTERVENTION; FEMALE; GENE MUTATION; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HETEROZYGOSITY; HUMAN; HYPERGLYCEMIA; KCNJ11 GENE; MALE; NECROTIZING ENTEROCOLITIS; NEWBORN; NEWBORN DIABETES MELLITUS; NOTE; PRESCHOOL CHILD; REMISSION; DIABETES MELLITUS; DRUG ADMINISTRATION; SEVERITY OF ILLNESS INDEX;

CHILD; DIABETES MELLITUS; DRUG ADMINISTRATION SCHEDULE; EARLY MEDICAL INTERVENTION; FEMALE; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; INFANT, NEWBORN; INSULIN; MALE; REMISSION INDUCTION; SEVERITY OF ILLNESS INDEX; SULFONYLUREA COMPOUNDS;

EID: 84962428097     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-2124     Document Type: Note

References (5)

1. Gloyn AL, Cummings EA, Edghill EL, et al. Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab 2004; 89:3932-3935.
2. Karges B, Meissner T, Icks A, Kapellen T, Holl RW. Management of diabetes mellitus in infants. Nat Rev Endocrinol 2012;8:201-211.
3. Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG. Successful sulfonylurea treatment of an insulin-näive neonate with diabetes mellitus due to a KCNJ11 mutation. Pediatr Diabetes 2010;11:286-288.
4. Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG. Acute sulfonylurea therapy at disease onset can cause permanent remission of KATPinduced diabetes. Diabetes 2011;60:2515-2522.
5. Khurana D, Contreras M, Malhotra N, Bargman R. The diagnosis of neonatal diabetes in a mother at 25 years of age. Diabetes Care 2012;35:e59.