Vogt-Koyanagi-Harada disease: Review of a rare autoimmune disease targeting antigens of melanocytes

Orphanet Journal of Rare Diseases

Volumn 11, Issue 1, 2016, Pages

  Lavezzo, Marcelo Mendes ^a   Sakata, Viviane Mayumi ^a   Morita, Celso ^a   Rodriguez, Ever Ernesto Caso ^a   Abdallah, Smairah Frutuoso ^a   Da Silva, Felipe T G ^a   Hirata, Carlos Eduardo ^a   Yamamoto, Joyce Hisae ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Review; Uveitis; Vogt Koyanagi Harada disease

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOPLEGIC AGENT; CYCLOSPORIN A; INFLIXIMAB; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLATE MOFETIL; MYDRIATIC AGENT; PREDNISONE;

ALOPECIA; AUTOFLUORESCENCE IMAGING; AUTOIMMUNE DISEASE; BILATERAL CHRONIC IRIDOCYCLITIS; CATARACT; CLINICAL FEATURE; DRUG TARGETING; ECHOOCULOGRAPHY; ELECTRORETINOGRAM; EYE INJURY; GLAUCOMA; HEADACHE; HEARING IMPAIRMENT; HUMAN; INDOCYANINE GREEN ANGIOGRAPHY; IRIDOCYCLITIS; LUMBAR PUNCTURE; MELANOCYTE; MENINGISM; NONHUMAN; OCULAR FIBROSIS; OPTICAL COHERENCE TOMOGRAPHY; PAPILLEDEMA; PIGMENT DISORDER; POLIOSIS; RARE DISEASE; RETINA DETACHMENT; RETINA FLUORESCEIN ANGIOGRAPHY; REVIEW; STIFF NECK; SUBRETINAL NEOVASCULARIZATION; TINNITUS; TREATMENT DURATION; UVEITIS; VITILIGO; VOGT KOYANAGI SYNDROME; ANIMAL; IMMUNOLOGY; MENINGOENCEPHALITIS; METABOLISM;

ANIMALS; AUTOIMMUNE DISEASES; HUMANS; MELANOCYTES; RARE DISEASES; UVEITIS; UVEOMENINGOENCEPHALITIC SYNDROME;

EID: 84962425225     PISSN: None     EISSN: 17501172     Source Type: Journal    
DOI: 10.1186/s13023-016-0412-4     Document Type: Review

References (183)

1. Moorthy RS, Inomata H, Rao NA. Vogt-Koyanagi-Harada syndrome. Surv Ophthalmol. 1995;39(4):265-92.
2. Herbort CP, Mochizuki M. Vogt-Koyanagi-Harada disease: inquiry into the genesis of a disease name in the historical context of Switzerland and Japan. Int Ophthalmol. 2007;27(2-3):67-79.
3. Marmor MF, Ravin JG. Chapter 34 - Goya's Strange Malady. In: The Artist's Eyes - Vision and the History of Art. New York: Abrams; 2009. p. 184-7.
4. Rao NA, Gupta A, Dustin L, Chee SP, Okada AA, Khairallah M, et al. Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease. Ophthalmology. 2010;117(3):591-9. 9 e1.
5. Ohguro N, Sonoda KH, Takeuchi M, Matsumura M, Mochizuki M. The 2009 prospective multi-center epidemiologic survey of uveitis in Japan. Jpn J Ophthalmol. 2012;56(5):432-5.
6. Ohno S, Char DH, Kimura SJ, O'Connor GR. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1977;83(5):735-40.
7. Gouveia EB, Yamamoto JH, Abdalla M, Hirata CE, Kubo P, Olivalves E. Causas das uveítes em serviço terciário em São Paulo, Brasil. Arq Bras Oftalmol. 2004;67(1):139-45.
8. Belfort Jr R, Nishi M, Hayashi S, Abreu MT, Petrilli AM, Plut RC. Vogt-Koyanagi-Harada's disease in Brazil. Jpn J Ophthalmol. 1988;32:344-7.
9. Yang P, Zhang Z, Zhou H, Li B, Huang X, Gao Y, et al. Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res. 2005;30(11):943-8.
10. Rubsamen PE, Gass JD. Vogt-Koyanagi-Harada syndrome. Clinical course, therapy, and long-term visual outcome. Arch Ophthalmol. 1991;109(5):682-7.
11. Martin TD, Rathinam SR, Cunningham Jr ET. Prevalence, clinical characteristics, and causes of vision loss in children with Vogt-Koyanagi-Harada disease in South India. Retina. 2010;30(7):1113-21.
12. Hamade IH, Al Shamsi HN, Al Dhibi H, Chacra CB, Abu El-Asrar AM, Tabbara KF. Uveitis survey in children. Br J Ophthalmol. 2009;93(5):569-72.
13. Ikeda N, Hayasaka S, Hayasaka Y. Uveitis and pseudouveitis presenting for the first time in Japanese elderly patients. Ophthalmologica. 2005;219(5):263-6.
14. Kiyomoto C, Imaizumi M, Kimoto K, Abe H, Nakano S, Nakatsuka K. Vogt-Koyanagi-Harada disease in elderly Japanese patients. Int Ophthalmol. 2007;27(2-3):149-53.
15. Bassili SS, Peyman GA, Gebhardt BM, Daun M, Ganiban GJ, Rifai A. Detection of Epstein-Barr virus DNA by polymerase chain reaction in the vitreous from a patient with Vogt-Koyanagi-Harada syndrome. Retina. 1996;16(2):160-1.
16. Sugita S, Takase H, Kawaguchi T, Taguchi C, Mochizuki M. Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007;27(2-3):87-95.
17. Matsuda H. Electron microscopic studies on Vogt-Koyanagi-Harada syndrome and sympathetic ophthalmia with special reference to the melanocyte. Nihon Ganka Gakkai Zasshi. 1970;74(9):1107-12.
18. Hammer H. Cellular hypersensitivity to uveal pigment confirmed by leucocyte migration tests in sympathetic ophthalmitis and the Vogt-Koyanagi-Harada syndrome. Br J Ophthalmol. 1974;58(9):773-6.
19. Maezawa N, Yano A. Two distinct cytotoxic T lymphocyte subpopulations in patients with Vogt-Koyanagi-Harada disease that recognize human melanoma cells. Microbiol Immunol. 1984;28(2):219-31.
20. Norose K, Yano A, Aosai F, Segawa K. Immunologic analysis of cerebrospinal fluid lymphocytes in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 1990;31(7):1210-6.
21. McClellan KA, MacDonald M, Hersey P, Billson FA. Vogt-Koyanagi-Harada syndrome - isolation of cloned T cells with specificity for melanocytes and melanoma cells. Aust N Z J Ophthalmol. 1989;17(4):347-52.
22. Kawakami Y, Robbins PF, Rosenberg SA. Human melanoma antigens recognized by T lymphocytes. Keio J Med. 1996;45(2):100-8.
23. Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S. Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol. 2000;165(12):7323-9.
24. Gocho K, Kondo I, Yamaki K. Identification of autoreactive T cells in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 2001;42(9):2004-9.
25. Sugita S, Takase H, Taguchi C, Imai Y, Kamoi K, Kawaguchi T, et al. Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens. Invest Ophthalmol Vis Sci. 2006;47(6):2547-54.
26. Damico FM, Cunha-Neto E, Goldberg AC, Iwai LK, Marin ML, Hammer J, et al. T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1∗0405-positive and -negative Vogt-Koyanagi-Harada uveitis. Invest Ophthalmol Vis Sci. 2005;46(7):2465-71.
27. Yamaki K, Kondo I, Nakamura H, Miyano M, Konno S, Sakuragi S. Ocular and extraocular inflammation induced by immunization of tyrosinase related protein 1 and 2 in Lewis rats. Exp Eye Res. 2000;71(4):361-9.
28. Sakamoto T, Murata T, Inomata H. Class II major histocompatibility complex on melanocytes of Vogt-Koyanagi-Harada disease. Arch Ophthalmol. 1991;109(9):1270-4.
29. Inomata H, Sakamoto T. Immunohistochemical studies of Vogt-Koyanagi-Harada disease with sunset sky fundus. Curr Eye Res. 1990;9(Suppl):35-40.
30. Davis JL, Mittal KK, Freidlin V, Mellow SR, Optican DC, Palestine AG, et al. HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. Ophthalmology. 1990;97(9):1137-42.
31. Tagawa Y, Sugiura S, Yakura H, Wakisaka A, Aizawa M. The association between major histocompatibility antigens (HLA) and Vogt-Koyanagi-Harada syndrome (author's transl). Nihon Ganka Gakkai Zasshi. 1976;80(8):486-90.
32. Shindo Y, Inoko H, Yamamoto T, Ohno S. HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-RFLP and the strong association with DRB1∗0405 and DRB1∗0410. Br J Ophthalmol. 1994;78(3):223-6.
33. Islam SM, Numaga J, Fujino Y, Hirata R, Matsuki K, Maeda H, et al. HLA class II genes in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 1994;35(11):3890-6.
34. Zhang XY, Wang XM, Hu TS. Profiling human leukocyte antigens in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1992;113(5):567-72.
35. Weisz JM, Holland GN, Roer LN, Park MS, Yuge AJ, Moorthy RS, et al. Association between Vogt-Koyanagi-Harada syndrome and HLA-DR1 and -DR4 in Hispanic patients living in southern California. Ophthalmology. 1995;102(7):1012-5.
36. Goldberg AC, Yamamoto JH, Chiarella JM, Marin ML, Sibinelli M, Neufeld R, et al. HLA-DRB1∗0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease. Hum Immunol. 1998;59(3):183-8.
37. Ng JY, Luk FO, Lai TY, Pang CP. Influence of molecular genetics in Vogt-Koyanagi-Harada disease. J Ophthalmic Inflamm Infect. 2014;4:20.
38. Hou S, Du L, Lei B, Pang CP, Zhang M, Zhuang W, et al. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. Nat Genet. 2014;46(9):1007-11.
39. Rao NA. Mechanisms of inflammatory response in sympathetic ophthalmia and VKH syndrome. Eye (Lond). 1997;11(Pt 2):213-6.
40. Damico FM, Bezerra FT, Silva GC, Gasparin F, Yamamoto JH. New insights into Vogt-Koyanagi-Harada disease. Arq Bras Oftalmol. 2009;72(3):413-20.
41. Imai Y, Sugita M, Nakamura S, Toriyama S, Ohno S. Cytokine production and helper T cell subsets in Vogt-Koyanagi-Harada's disease. Curr Eye Res. 2001;22(4):312-8.
42. Chi W, Yang P, Li B, Wu C, Jin H, Zhu X, et al. IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J Allergy Clin Immunol. 2007;119(5):1218-24.
43. Shu Q, Yang P, Hou S, Li F, Chen Y, Du L, et al. Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behcet's disease in a Chinese Han population. Hum Immunol. 2010;71(10):988-91.
44. Li F, Yang P, Liu X, Wang C, Hou S, Kijlstra A. Upregulation of interleukin 21 and promotion of interleukin 17 production in chronic or recurrent Vogt-Koyanagi-Harada disease. Arch Ophthalmol. 2010;128(11):1449-54.
45. Wang C, Tian Y, Lei B, Xiao X, Ye Z, Li F, et al. Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 2012;53(8):4668-75.
46. Commodaro AG, Peron JP, Genre J, Arslanian C, Sanches L, Muccioli C, et al. IL-10 and TGF-beta immunoregulatory cytokines rather than natural regulatory T cells are associated with the resolution phase of Vogt-Koyanagi-Harada (VKH) syndrome. Scand J Immunol. 2010;72(1):31-7.
47. Chen L, Yang P, Zhou H, He H, Ren X, Chi W, et al. Diminished frequency and function of CD4 + CD25high regulatory T cells associated with active uveitis in Vogt-Koyanagi-Harada syndrome. Invest Ophthalmol Vis Sci. 2008;49(8):3475-82.
48. Chen W, Lin H, Zhong X, Liu Z, Geng Y, Xie C, et al. Discrepant expression of cytokines in inflammation- and age-related cataract patients. PLoS One. 2014;9(10):e109647.
49. Naidu YM, Pararajasegaram G, Sun Y, et al. Predominant expression of T-cell antigen receptor (TCR) Vα 10 in Vogt-Koyanagi-Harada (VKH) syndrome. Invest Ophthalmol Vis Sci. 1991;32(suppl):934.
50. de Smet MD, Yamamoto JH, Mochizuki M, Gery I, Singh VK, Shinohara T, et al. Cellular immune responses of patients with uveitis to retinal antigens and their fragments. Am J Ophthalmol. 1990;110(2):135-42.
51. Chan CC, Palestine AG, Nussenblatt RB, Roberge FG, Benezra D. Anti-retinal auto-antibodies in Vogt-Koyanagi-Harada syndrome, Behcet's disease, and sympathetic ophthalmia. Ophthalmology. 1985;92(8):1025-8.
52. Shinzato M, Yamamoto JH, Hirata CE, Olivalves E, Bonfa E. Anti-SS-A/Ro reactivity in patients with Vogt-Koyanagi-Harada syndrome. Lupus. 2004;13(4):279-80.
53. Rao NA. Pathology of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007;27(2-3):81-5.
54. Inomata H, Rao NA. Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2001;131(5):607-14.
55. Morohashi M, Hashimoto K, Goodman Jr TF, Newton DE, Rist T. Ultrastructural studies of vitiligo, Vogt-Koyanagi syndrome, and incontinentia pigmenti achromians. Arch Dermatol. 1977;113(6):755-66.
56. Snyder DA, Tessler HH. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1980;90(1):69-75.
57. Sugiura S. Some observations on uveitis in Japan, with special reference to Vogt-Koyanagi-Harada and Behcet diseases (author's transl). Nihon Ganka Gakkai Zasshi. 1976;80(11):1285-326.
58. Sugiura S. Vogt-Koyanagi-Harada Disease. Jpn J Ophthalmol. 1978;22:9-35.
59. Read RW, Holland GN, Rao NA, Tabbara KF, Ohno S, Arellanes-Garcia L, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol. 2001;131(5):647-52.
60. Herbort CP, LeHoang P, Guex-Crosier Y. Schematic interpretation of indocyanine green angiography in posterior uveitis using a standard angiographic protocol. Ophthalmology. 1998;105(3):432-40.
61. Herbort CP, Mantovani A, Bouchenaki N. Indocyanine green angiography in Vogt-Koyanagi-Harada disease: angiographic signs and utility in patient follow-up. Int Ophthalmol. 2007;27(2-3):173-82.
62. Fardeau C, Tran TH, Gharbi B, Cassoux N, Bodaghi B, LeHoang P. Retinal fluorescein and indocyanine green angiography and optical coherence tomography in successive stages of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007;27(2-3):163-72.
63. da Silva FT, Damico FM, Marin ML, Goldberg AC, Hirata CE, Takiuti PH, et al. Revised diagnostic criteria for vogt-koyanagi-harada disease: considerations on the different disease categories. Am J Ophthalmol. 2009;147(2):339-45. e5.
64. da Silva FT, Hirata CE, Olivalves E, Oyamada MK, Yamamoto JH. Fundus-based and electroretinographic strategies for stratification of late-stage Vogt-Koyanagi-Harada disease patients. Am J Ophthalmol. 2009;148(6):939-45. e3.
65. Al Dousary S. Auditory and vestibular manifestations of Vogt-Koyanagi-Harada disease. J Laryngol Otol. 2011;125(2):138-41.
66. Yang P, Ren Y, Li B, Fang W, Meng Q, Kijlstra A. Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients. Ophthalmology. 2007;114(3):606-14.
67. Usui Y, Goto H, Sakai J, Takeuchi M, Usui M, Rao NA. Presumed Vogt-Koyanagi-Harada disease with unilateral ocular involvement: report of three cases. Graefes Arch Clin Exp Ophthalmol. 2009;247(8):1127-32.
68. Sakata VM, da Silva FT, Hirata CE, Marin ML, Rodrigues H, Kalil J, et al. High rate of clinical recurrence in patients with Vogt-Koyanagi-Harada disease treated with early high-dose corticosteroids. Graefes Arch Clin Exp Ophthalmol. 2015;253(5):785-90.
69. Knecht PB, Mantovani A, Herbort CP. Indocyanine green angiography-guided management of Vogt-Koyanagi-Harada disease: differentiation between choroidal scars and active lesions. Int Ophthalmol. 2013;33(5):571-7.
70. da Silva FT, Hirata CE, Sakata VM, Olivalves E, Preti R, Pimentel SL, et al. Indocyanine green angiography findings in patients with long-standing Vogt-Koyanagi-Harada disease: a cross-sectional study. BMC Ophthalmol. 2012;12:40.
71. Gu S, Liu Y, Song Z, Zi X, Deng H. Acute myelitis in a patient with vogt-koyanagi-harada disease: case report and review of the literature. J Clin Neurol. 2013;9(1):61-4.
72. Beniz J, Forster DJ, Lean JS, Smith RE, Rao NA. Variations in clinical features of the Vogt-Koyanagi-Harada syndrome. Retina. 1991;11(3):275-80.
73. Barnes L. Vitiligo and the Vogt-Koyanagi-Harada syndrome. Dermatol Clin. 1988;6(2):229-39.
74. Friedman AH, Deutsch-Sokol RH. Sugiura's sign. Perilimbal vitiligo in the Vogt-Koyanagi-Harada syndrome. Ophthalmology. 1981;88(11):1159-65.
75. Fiore T, Iaccheri B, Androudi S, Papadaki TG, Anzaar F, Brazitikos P, et al. Acute posterior multifocal placoid pigment epitheliopathy: outcome and visual prognosis. Retina. 2009;29(7):994-1001.
76. Gill MK, Jampol LM. Variations in the presentation of primary intraocular lymphoma: case reports and a review. Surv Ophthalmol. 2001;45(6):463-71.
77. Gross NE, Yannuzzi LA, Freund KB, Spaide RF, Amato GP, Sigal R. Multiple evanescent white dot syndrome. Arch Ophthalmol. 2006;124(4):493-500.
78. Levinson RD, Brezin A, Rothova A, Accorinti M, Holland GN. Research criteria for the diagnosis of birdshot chorioretinopathy: results of an international consensus conference. Am J Ophthalmol. 2006;141(1):185-7.
79. McCluskey PJ, Watson PG, Lightman S, Haybittle J, Restori M, Branley M. Posterior scleritis: clinical features, systemic associations, and outcome in a large series of patients. Ophthalmology. 1999;106(12):2380-6.
80. Vianna RN, Ozdal PC, Filho JP, Ventura MP, Saraiva VS, Deschenes J. Longterm follow-up of patients with multifocal choroiditis and panuveitis. Acta Ophthalmol Scand. 2004;82(6):748-53.
81. Nguyen QD, Uy HS, Akpek EK, Harper SL, Zacks DN, Foster CS. Choroidopathy of systemic lupus erythematosus. Lupus. 2000;9(4):288-98.
82. Elagouz M, Stanescu-Segall D, Jackson TL. Uveal effusion syndrome. Surv Ophthalmol. 2010;55(2):134-45.
83. Rao NA, Marak GE. Sympathetic ophthalmia simulating vogt-Koyanagi-Harada's disease: a clinico-pathologic study of four cases. Jpn J Ophthalmol. 1983;27(3):506-11.
84. Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80(2):177-85.
85. Steiner S, Goldstein DA. Imaging in the diagnosis and management of APMPPE. Int Ophthalmol Clin. 2012;52(4):211-9.
86. Lee GE, Lee BW, Rao NA, Fawzi AA. Spectral domain optical coherence tomography and autofluorescence in a case of acute posterior multifocal placoid pigment epitheliopathy mimicking Vogt-Koyanagi-Harada disease: case report and review of literature. Ocul Immunol Inflamm. 2011;19(1):42-7.
87. Aoyagi R, Hayashi T, Masai A, Mitooka K, Gekka T, Kozaki K, et al. Subfoveal choroidal thickness in multiple evanescent white dot syndrome. Clin Exp Optom. 2012;95(2):212-7.
88. Vance SK, Khan S, Klancnik JM, Freund KB. Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. Retina. 2011;31(4):717-23.
89. Benson WE. Posterior scleritis. Surv Ophthalmol. 1988;32(5):297-316.
90. Carvalho-Recchia CA, Yannuzzi LA, Negrao S, Spaide RF, Freund KB, Rodriguez-Coleman H, et al. Corticosteroids and central serous chorioretinopathy. Ophthalmology. 2002;109(10):1834-7.
91. Shin WB, Kim MK, Lee CS, Lee SC, Kim H. Comparison of the clinical manifestations between acute Vogt-Koyanagi-Harada disease and acute bilateral central serous chorioretinopathy. Korean J Ophthalmol. 2015;29(6):389-95.
92. Wolfensberger TJ, Tufail A. Systemic disorders associated with detachment of the neurosensory retina and retinal pigment epithelium. Curr Opin Ophthalmol. 2000;11(6):455-61.
93. Aisenbrey S, Luke C, Ayertey HD, Grisanti S, Perniok A, Brunner R. Vogt-Koyanagi-Harada syndrome associated with cutaneous malignant melanoma: an 11-year follow-up. Graefes Arch Clin Exp Ophthalmol. 2003;241(12):996-9.
94. Souguir A, Hammami A, Dahmeni W, Jaziri H, Ben Mansour I, Zayene A, et al. Vogt-Koyanagi-Harada syndrome and Crohn's disease: an exceptional association. Gastroenterology report. 2015. [Epub ahead of print]
95. Federman DG, Kravetz JD, Ruser CB, Judson PH, Kirsner RS. Vogt-Koyanagi-Harada syndrome and ulcerative colitis. South Med J. 2004;97(2):169-71.
96. Kaya MK, Turgut B, Demir T, Celiker U, Gurates B. A case of vogt-koyanagi-harada disease associated with polycystic ovary syndrome. J Clin Med Res. 2011;3(2):93-5.
97. Sakata VM, da Silva FT, Hirata CE, de Carvalho JF, Yamamoto JH. Diagnosis and classification of Vogt-Koyanagi-Harada disease. Autoimmun Rev. 2014;13(4-5):550-5.
98. Arellanes-Garcia L, Hernandez-Barrios M, Fromow-Guerra J, Cervantes-Fanning P. Fluorescein fundus angiographic findings in Vogt-Koyanagi-Harada syndrome. Int Ophthalmol. 2007;27(2-3):155-61.
99. Stanga PE, Lim JI, Hamilton P. Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update. Ophthalmology. 2003;110(1):15-21. quiz 2-3.
100. Koizumi H, Maruyama K, Kinoshita S. Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2010;94(11):1499-505.
101. Heussen FM, Vasconcelos-Santos DV, Pappuru RR, Walsh AC, Rao NA, Sadda SR. Ultra-wide-field green-light (532-nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease. Ophthalmic Surg Lasers Imaging. 2011;42(4):272-7.
102. Ishihara K, Hangai M, Kita M, Yoshimura N. Acute Vogt-Koyanagi-Harada disease in enhanced spectral-domain optical coherence tomography. Ophthalmology. 2009;116(9):1799-807.
103. Nazari H, Rao NA. Resolution of subretinal fluid with systemic corticosteroid treatment in acute Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2012;96(11):1410-4.
104. Zhao C, Zhang MF, Dong FT, Wang XQ, Wen X, Dai RP, et al. Spectral domain optical coherence tomography of Vogt-Koyanagi-Harada disease: novel findings and new insights into the pathogenesis. Chin Med Sci J. 2012;27(1):29-34.
105. Ikewaki J, Kimoto K, Choshi T, Nagata M, Motomura Y, Tamura K, et al. Optical coherence tomographic assessment of dynamic macular changes in patients with Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2011;31(1):9-13.
106. Gupta V, Gupta A, Gupta P, Sharma A. Spectral-domain cirrus optical coherence tomography of choroidal striations seen in the acute stage of Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2009;147(1):148-53.e2.
107. Fong AH, Li KK, Wong D. Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina. 2011;31(3):502-9.
108. Yamanaka E, Ohguro N, Yamamoto S, Nakagawa Y, Imoto Y, Tano Y. Evaluation of pulse corticosteroid therapy for vogt-koyanagi-harada disease assessed by optical coherence tomography. Am J Ophthalmol. 2002;134(3):454-6.
109. Vasconcelos-Santos DV, Sohn EH, Sadda S, Rao NA. Retinal pigment epithelial changes in chronic Vogt-Koyanagi-Harada disease: fundus autofluorescence and spectral domain-optical coherence tomography findings. Retina. 2010;30(1):33-41.
110. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol. 2009;147(5):811-5.
111. Nakayama M, Keino H, Okada AA, Watanabe T, Taki W, Inoue M, et al. Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. Retina. 2012;32(10):2061-9.
112. Maruko I, Iida T, Sugano Y, Oyamada H, Sekiryu T, Fujiwara T, et al. Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina. 2011;31(3):510-7.
113. da Silva FT, Sakata VM, Nakashima A, Hirata CE, Olivalves E, Takahashi WY, et al. Enhanced depth imaging optical coherence tomography in long-standing Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2013;97(1):70-4.
114. Hashizume K, Imamura Y, Fujiwara T, Machida S, Ishida M, Kurosaka D. Choroidal thickness in eyes with posterior recurrence of Vogt-Koyanagi-Harada disease after high-dose steroid therapy. Acta Ophthalmol. 2014;92(6):e490-1.
115. Forster DJ, Cano MR, Green RL, Rao NA. Echographic features of the Vogt-Koyanagi-Harada syndrome. Arch Ophthalmol. 1990;108(10):1421-6.
116. Gohdo T, Tsukahara S. Ultrasound Biomicroscopy of shallow anterior chamber in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1996;122(1):112-4.
117. Chee SP, Luu CD, Cheng CL, Lim WK, Jap A. Visual function in Vogt-Koyanagi-Harada patients. Graefes Arch Clin Exp Ophthalmol. 2005;243(8):785-90.
118. Yang P, Fang W, Wang L, Wen F, Wu W, Kijlstra A. Study of macular function by multifocal electroretinography in patients with Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 2008;146(5):767-71.
119. Read RW, Yu F, Accorinti M, Bodaghi B, Chee SP, Fardeau C, et al. Evaluation of the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2006;142(1):119-24.
120. Kawaguchi T, Horie S, Bouchenaki N, Ohno-Matsui K, Mochizuki M, Herbort CP. Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2010;30(1):41-50.
121. Chee SP, Jap A, Bacsal K. Prognostic factors of Vogt-Koyanagi-Harada disease in Singapore. Am J Ophthalmol. 2009;147(1):154-61. e1.
122. Rao NA. Treatment of Vogt-Koyanagi-Harada disease by corticosteroids and immunosuppressive agents. Ocul Immunol Inflamm. 2006;14(2):71-2.
123. Chee S-P, Jap A. The outcomes of indocyanine green angiography monitored immunotherapy in Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2013;97(2):130-3.
124. Lai TY, Chan RP, Chan CK, Lam DS. Effects of the duration of initial oral corticosteroid treatment on the recurrence of inflammation in Vogt-Koyanagi-Harada disease. Eye (Lond). 2009;23(3):543-8.
125. Errera MH, Fardeau C, Cohen D, Navarro A, Gaudric A, Bodaghi B, et al. Effect of the duration of immunomodulatory therapy on the clinical features of recurrent episodes in Vogt - Koyanagi - Harada disease. Acta Ophthalmol. 2011;89(4):e357-66.
126. Jabs DA, Rosenbaum JT, Foster CS, Holland GN, Jaffe GJ, Louie JS, et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol. 2000;130(4):492-513.
127. Kempen JH, Gangaputra S, Daniel E, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, et al. Long-term risk of malignancy among patients treated with immunosuppressive agents for ocular inflammation: a critical assessment of the evidence. Am J Ophthalmol. 2008;146(6):802-12. e1.
128. Paredes I, Ahmed M, Foster CS. Immunomodulatory therapy for Vogt-Koyanagi-Harada patients as first-line therapy. Ocul Immunol Inflamm. 2006;14(2):87-90.
129. Kacmaz RO, Kempen JH, Newcomb C, Daniel E, Gangaputra S, Nussenblatt RB, et al. Cyclosporine for ocular inflammatory diseases. Ophthalmology. 2010;117(3):576-84.
130. Galor A, Jabs DA, Leder HA, Kedhar SR, Dunn JP, Peters 3rd GB, et al. Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation. Ophthalmology. 2008;115(10):1826-32.
131. Kondo Y, Fukuda K, Suzuki K, Nishida T. Chronic noninfectious uveitis associated with Vogt-Koyanagi-Harada disease treated with low-dose weekly systemic methotrexate. Jpn J Ophthalmol. 2012;56(1):104-6.
132. Abu El-Asrar AM, Hemachandran S, Al-Mezaine HS, Kangave D, Al-Muammar AM. The outcomes of mycophenolate mofetil therapy combined with systemic corticosteroids in acute uveitis associated with Vogt-Koyanagi-Harada disease. Acta Ophthalmol. 2012;90(8):e603-8.
133. Urzua CA, Velasquez V, Sabat P, Berger O, Ramirez S, Goecke A, et al. Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with Vogt-Koyanagi-Harada disease. Acta Ophthalmol. 2015;93:e475-80.
134. Kim SJ, Yu HG. The use of low-dose azathioprine in patients with Vogt-Koyanagi-Harada disease. Ocul Immunol Inflamm. 2007;15(5):381-7.
135. Wang Y, Gaudio PA. Infliximab therapy for 2 patients with Vogt-Koyanagi-Harada syndrome. Ocul Immunol Inflamm. 2008;16(4):167-71.
136. Niccoli L, Nannini C, Cassara E, Gini G, Lenzetti I, Cantini F. Efficacy of infliximab therapy in two patients with refractory Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2009;93(11):1553-4.
137. Dolz-Marco R, Gallego-Pinazo R, Diaz-Llopis M. Rituximab in refractory Vogt-Koyanagi-Harada disease. J Ophthalmic Inflamm Infect. 2011;1(4):177-80.
138. Andrade RE, Muccioli C, Farah ME, Nussenblatt RB, Belfort Jr R. Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 2004;137(3):572-4.
139. Karacorlu M, Arf Karacorlu S, Ozdemir H. Intravitreal triamcinolone acetonide in Vogt-Koyanagi-Harada syndrome. Eur J Ophthalmol. 2006;16(3):481-3.
140. Park HS, Nam KY, Kim JY. Intravitreal bevacizumab injection for persistent serous retinal detachment associated with Vogt-Koyanagi-Harada disease. Graefes Arch Clin Exp Ophthalmol. 2011;249(1):133-6.
141. Khalifa Y, Loh AR, Acharya NR. Fluocinolone acetonide intravitreal implants in Vogt-Koyanagi-Harada disease. Ocul Immunol Inflamm. 2009;17(6):431-3.
142. Tabbara KF, Chavis PS, Freeman WR. Vogt-Koyanagi-Harada syndrome in children compared to adults. Acta Ophthalmol Scand. 1998;76(6):723-6.
143. Soheilian M, Aletaha M, Yazdani S, Dehghan MH, Peyman GA. Management of pediatric Vogt-Koyanagi- Harada (VKH)-associated panuveitis. Ocul Immunol Inflamm. 2006;14(2):91-8.
144. Abu El-Asrar AM, Al-Kharashi AS, Aldibhi H, Al-Fraykh H, Kangave D. Vogt-Koyanagi-Harada disease in children. Eye (Lond). 2008;22(9):1124-31.
145. Friedman Z, Granat M, Neumann E. The syndrome of Vogt-Koyanagi-Harada and pregnancy. Metab Pediatr Ophthalmol. 1980;4(3):147-9.
146. Miyata N, Sugita M, Nakamura S, Isobe K, Matoba H, Tsuda K, et al. Treatment of Vogt-Koyanagi- Harada's disease during pregnancy. Jpn J Ophthalmol. 2001;45(2):177-80.
147. Doi M, Matsubara H, Uji Y. Vogt-Koyanagi-Harada syndrome in a pregnant patient treated with high-dose systemic corticosteroids. Acta Ophthalmol Scand. 2000;78(1):93-6.
148. Tien MC, Teoh SC. Treatment of Vogt-Koyanagi-Harada syndrome in pregnancy. Can J Ophthalmol. 2009;44(2):211-2.
149. Onishi SM, Asahi MG, Chou C, Gallemore RP. Topical difluprednate for the treatment of Harada's disease. Clin Ophthalmol. 2015;9:157-67.
150. Maya JR, Sadiq MA, Zapata LJ, Hanout M, Sarwar S, Rajagopalan N, et al. Emerging therapies for noninfectious uveitis: what may be coming to the clinics. J Ophthalmol. 2014;2014:310329.
151. Rutzen AR, Ortega-Larrocea G, Frambach DA, Rao NA. Macular edema in chronic Vogt-Koyanagi-Harada syndrome. Retina. 1995;15(6):475-9.
152. Khairallah M, Rao NA, Ben Yahia S, Zaouali S, Attia S. Pseudotumoral retinal pigment epithelium proliferation in a patient with Vogt-Koyanagi-Harada disease. Arch Ophthalmol. 2006;124(9):1366-7.
153. Yang P, Sun M. Band-shaped keratopathy in Chinese patients with Vogt-Koyanagi-Harada syndrome. Cornea. 2011;30(12):1336-40.
154. Nakao K, Mizushima Y, Abematsu N, Goh N, Sakamoto T. Anterior ischemic optic neuropathy associated with Vogt-Koyanagi-Harada disease. Graefes Arch Clin Exp Ophthalmol. 2009;247(10):1417-25.
155. Moorthy RS, Rajeev B, Smith RE, Rao NA. Incidence and management of cataracts in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1994;118(2):197-204.
156. Mehta S, Linton MM, Kempen JH. Outcomes of cataract surgery in patients with uveitis: a systematic review and meta-analysis. Am J Ophthalmol. 2014;158(4):676-92. e7.
157. Quek DT, Jap A, Chee SP. Risk factors for poor visual outcome following cataract surgery in Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2011;95(11):1542-6.
158. Ganesh SK, Padmaja, Babu K, Biswas J. Cataract surgery in patients with Vogt-Koyanagi-Harada syndrome. J Cataract Refract Surg. 2004;30(1):95-100.
159. Meacock WR, Spalton DJ, Bender L, Antcliff R, Heatley C, Stanford MR, et al. Steroid prophylaxis in eyes with uveitis undergoing phacoemulsification. Br J Ophthalmol. 2004;88(9):1122-4.
160. Lundvall A, Zetterstrom C. Cataract extraction and intraocular lens implantation in children with uveitis. Br J Ophthalmol. 2000;84(7):791-3.
161. Ram J, Gupta A, Kumar S, Kaushik S, Gupta N, Severia S. Phacoemulsification with intraocular lens implantation in patients with uveitis. J Cataract Refract Surg. 2010;36(8):1283-8.
162. Read RW, Rechodouni A, Butani N, Johnston R, LaBree LD, Smith RE, et al. Complications and prognostic factors in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2001;131(5):599-606.
163. Takahashi T, Ohtani S, Miyata K, Miyata N, Shirato S, Mochizuki M. A clinical evaluation of uveitis-associated secondary glaucoma. Jpn J Ophthalmol. 2002;46(5):556-62.
164. Iwao K, Inatani M, Seto T, Takihara Y, Ogata-Iwao M, Okinami S, et al. Long-term outcomes and prognostic factors for trabeculectomy with mitomycin C in eyes with uveitic glaucoma: a retrospective cohort study. J Glaucoma. 2014;23(2):88-94.
165. Kolomeyer AM, Roy MS, Chu DS. The use of intravitreal ranibizumab for choroidal neovascularization associated with vogt-koyanagi-harada syndrome. Case Rep Med. 2011;2011:747648.
166. Wu L, Evans T, Saravia M, Schlaen A, Couto C. Intravitreal bevacizumab for choroidal neovascularization secondary to Vogt-Koyanagi-Harada syndrome. Jpn J Ophthalmol. 2009;53(1):57-60.
167. Mansour AM, Arevalo JF, Ziemssen F, Mehio-Sibai A, Mackensen F, Adan A, et al. Long-term visual outcomes of intravitreal bevacizumab in inflammatory ocular neovascularization. Am J Ophthalmol. 2009;148(2):310-6. e2.
168. Nowilaty SR, Bouhaimed M. Photodynamic therapy for subfoveal choroidal neovascularisation in Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2006;90(8):982-6.
169. Soheilian M, Movaseghi M, Ramezani A, Peyman GA. Pilot study of safety and effect of combined intravitreal bevacizumab and methotrexate for neovascular age-related macular degeneration. Eur J Ophthalmol. 2011;21(1):77-82.
170. Lertsumitkul S, Whitcup SM, Nussenblatt RB, Chan CC. Subretinal fibrosis and choroidal neovascularization in Vogt-Koyanagi-Harada syndrome. Graefes Arch Clin Exp Ophthalmol. 1999;237(12):1039-45.
171. Lertsumitkul S, Whitcup SM, Chan CC, Nussenblatt RB. Subretinal fibrosis in Vogt-Koyanagi Harada syndrome. Ophthalmology. 2001;108(8):1371.
172. Kuo IC, Rechdouni A, Rao NA, Johnston RH, Margolis TP, Cunningham Jr ET. Subretinal fibrosis in patients with Vogt-Koyanagi-Harada disease. Ophthalmology. 2000;107(9):1721-8.
173. Ozdal P, Ozdamar Y, Yazici A, Teke MY, Ozturk F. Vogt-Koyanagi-Harada disease: clinical and demographic characteristics of patients in a specialized eye hospital in Turkey. Ocul Immunol Inflamm. 2014;22(4):277-86.
174. Bacsal K, Wen DSH, Chee S-P. Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2008;145(3):480-6.
175. Keino H, Goto H, Usui M. Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation. Graefes Arch Clin Exp Ophthalmol. 2002;240(10):878-82.
176. Ohno S, Minakawa R, Matsuda H. Clinical studies of Vogt-Koyanagi-Harada's disease. Jpn J Ophthalmol. 1988;32(3):334-43.
177. Al-Kharashi AS, Aldibhi H, Al-Fraykh H, Kangave D, Abu El-Asrar AM. Prognostic factors in Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007;27(2-3):201-10.
178. Jap A, Luu CD, Yeo I, Chee SP. Correlation between peripapillary atrophy and corticosteroid therapy in patients with Vogt-Koyanagi-Harada disease. Eye (Lond). 2008;22(2):240-5.
179. Islam SM, Numaga J, Matsuki K, Fujino Y, Maeda H, Masuda K. Influence of HLA-DRB1 gene variation on the clinical course of Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 1994;35(2):752-6.
180. Sonoda S, Nakao K, Ohba N. Extensive chorioretinal atrophy in Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol. 1999;43(2):113-9.
181. Chee SP, Jap A, Cheung CM. The prognostic value of angiography in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2010;150(6):888-93.
182. Horie Y, Kitaichi N, Takemoto Y, Namba K, Yoshida K, Hirose S, et al. Polymorphism of IFNgamma gene and Vogt-Koyanagi-Harada disease. Mol Vis. 2007;13:2334-8.
183. Forster DJ, Rao NA, Hill RA, Nguyen QH, Baerveldt G. Incidence and management of glaucoma in Vogt-Koyanagi-Harada syndrome. Ophthalmology. 1993;100(5):613-8.