Switching of platelet P2Y12 receptor inhibitors in patients with acute coronary syndromes undergoing percutaneous coronary intervention: Review of the literature and practical considerations

American Heart Journal

Volumn 176, Issue , 2016, Pages 44-52

  De Luca, Leonardo ^a   Capranzano, Piera ^b   Patti, Giuseppe ^c   Parodi, Guido ^d  

^a EUROPEAN HOSPITAL   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^d CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CANGRELOR; CLOPIDOGREL; PLACEBO; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; TICAGRELOR; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ACUTE CORONARY SYNDROME; CORONARY STENTING; DRUG MEGADOSE; DRUG RESPONSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; HUMAN; LOADING DRUG DOSE; MEDICAL LITERATURE; MULTICENTER STUDY (TOPIC); OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PLATELET REACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; CHEMICALLY INDUCED; DRUG ADMINISTRATION ROUTE; POSTOPERATIVE COMPLICATION; PROCEDURES;

ACUTE CORONARY SYNDROME; DRUG ADMINISTRATION ROUTES; DRUG SUBSTITUTION; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); PERCUTANEOUS CORONARY INTERVENTION; POSTOPERATIVE COMPLICATIONS; PURINERGIC P2Y RECEPTOR ANTAGONISTS;

EID: 84962381098     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2016.03.006     Document Type: Review

References (45)

1. M. Roffi, C. Patrono, J.P. Collet, and et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation Eur Heart J 2015 10.1093/eurheartj/ehv320
2. E.A. Amsterdam, N.K. Wenger, R.G. Brindis, and et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 64 2014 2645 2687
3. A. Shöming Ticagrelor - is there need for a new player in the antiplatelet-therapy field? N Engl J Med 361 2009 1108 1111
4. M. Cattaneo New P2Y(12) inhibitors Circulation 121 2010 171 179
5. S.D. Wiviott, E. Braunwald, C.H. McCabe, and et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 2007 2001 2015
6. L. Wallentin, R.C. Becker, A. Budaj, and et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 61 2009 1045 1057
7. G. Parodi, G. De Luca, B. Bellandi, and et al. Switching from clopidogrel to prasugrel in patients having coronary stent implantation J Thromb Thrombolysis 38 2014 395 401
8. L. De Luca, L. Bcbolognese, M. Valgimigli, and et al. ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome Eur Heart J 16 Supplement C 2014 C2 C28
9. F. Rollini, F. Franchi, and D.J. Angiolillo Switching P2Y12-receptor inhibitors in patients with coronary artery disease Nat Rev Cardiol 2015 10.1038/nrcardio.2015.113
10. P.A. Gurbel, K.P. Bliden, K. Butler, and et al. Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study Circulation 121 2010 1188 1199
11. G. Caiazzo, S. De Rosa, D. Torella, and et al. Administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome Circ Cardiovasc Interv 7 2014 104 112
12. D.J. Angiolillo, J.F. Saucedo, R. Deraar, and et al. Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (SWitching Anti Platelet) study J Am Coll Cardiol 56 2010 1017 1023
13. J.G. Diodati, J.F. Saucedo, J.K. French, and et al. Effect on platelet reactivity from a prasugrel loading dose after a clopidogrel loading dose compared with a prasugrel loading dose alone: Transferring From Clopidogrel Loading Dose to Prasugrel Loading Dose in Acute Coronary Syndrome Patients (TRIPLET): a randomized controlled trial Circ Cardiovasc Interv 6 2013 567 574
14. M. Kerneis, J. Silvain, J. Abtain, and et al. Switching acute coronary syndrome patients from prasugrel to clopidogrel JACC Cardiovasc Interv 6 2013 158 165
15. D.J. Angiolillo, and F. Rollini Switching from prasugrel to clopidogrel: navigating in unknown waters JACC Cardiovasc Interv 6 2013 166 168
16. G. Parodi, and R.F. Storey Dyspnoea management in acute coronary syndrome patients treated with ticagrelor Eur Heart J Acute Cardiovasc Care 2014 2015;4:555-60.
17. D.J. Angiolillo, N. Curzen, P. Gurbel, and et al. Pharmacodynamic evaluation of switching from ticagrelor to prasugrel in subjects with stable coronary artery disease: results of the SWAP-2 Study J Am Coll Cardiol 63 2014 1500 1509
18. S. Husted, and J.J. van Giezen Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist Cardiovasc Ther 27 2009 259 274
19. G. Parodi, B. Bellandi, and D. Antoniucci Switching from ticagrelor to prasugrel: a warning Int J Cardiol 176 2014 1089 1090
20. H. Wu, Q. Wang, J. Zhou, and et al. First report of stent thrombosis after a switch therapy resulting from ticagrelor-related dyspnea Int J Cardiol 176 2014 e127 e128
21. D. Alexopoulos, A. Galati, I. Xanthopoulou, and et al. Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study J Am Coll Cardiol 60 2012 193 199
22. D.J. Angiolillo, M.S. Firstenberg, M.J. Price, and et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery. A randomized controlled trial JAMA 307 2012 265 274
23. R.A. Harrington, G.W. Stone, S. McNulty, and et al. Platelet inhibition with cangrelor in patients undergoing PCI N Engl J Med 361 2009 2318 2329
24. D.L. Bhatt, A.M. Lincoff, C.M. Gibson, and et al. Intravenous platelet blockade with cangrelor during PCI N Engl J Med 361 2009 2330 2341
25. D.L. Bhatt, G.W. Stone, K.W. Mahaffey, and et al. Effect of platelet inhibition with cangrelor during PCI on ischemic events N Engl J Med 368 2013 1303 1313
26. B. Aleil, C. Ravanat, J.P. Cazenave, and et al. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases J Thromb Haemost 3 2005 85 92
27. F. Rollini, F. Franchi, A. Tello-Montoliu, and et al. Pharmacodynamic effects of cangrelor on platelet P2Y12 receptor-mediated signaling in prasugrel-treated patients JACC Cardiovasc Intv 7 2014 427 434
28. D.J. Schneider Transition strategies from cangrelor to oral platelet P2Y12 receptor antagonists Coron Artery Dis 27 2016 65 69
29. S.R. Steinhubl, J.J. Oh, J.H. Oestreich, and et al. Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect Thromb Res 121 2008 527 534
30. N.L. Dovlatova, J.A. Jakubowski, A. Sugidachi, and et al. The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function J Thromb Haemost 6 2008 1153 1159
31. D.J. Schneider, N. Seecheran, S.S. Raza, and et al. Pharmacodynamic effects during the transition between cangrelor and prasugrel Coron Artery Dis 26 2015 42 48
32. H.M. Judge, R.J. Buckland, J.A. Jakubowski, and et al. Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y12 receptors in vitro Platelets 13 2015 1 5 [Epub ahead of print]
33. A. Ravnefjord, J. Weilitz, B.M. Emanuelsson, and et al. Evaluation of ticagrelor pharmacodynamic interactions with reversibly binding or non-reversibly binding P2Y(12) antagonists in an ex-vivo canine model Thromb Res 130 2012 622 628
34. D.J. Schneider, Z. Agarwal, N. Seecheran, and et al. Pharmacodynamic effects during the transition between cangrelor and ticagrelor JACC Cardiovasc Intv 7 2014 435 442
35. D. Alexopoulos, I. Xanthopoulou, S. Deftereos, and et al. In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prevalence, predictors and short-term outcome Am Heart J 167 2014 68 76
36. P. Clemmensen, N. Grieco, H. Ince, and et al. MULTInational non-interventional study of patients with ST-segment elevation myocardial infarction treated with PRimary Angioplasty and Concomitant use of upstream antiplatelet therapy with prasugrel or clopidogrel - the European MULTIPRAC Registry Eur Heart J Acute Cardiovasc Care 4 2015 220 229
37. A. Bagai, E.D. Peterson, E. Honeycutt, and et al. In-hospital switching between adenosine diphosphate receptor inhibitors in patients with acute myocardial infarction treated with percutaneous coronary intervention: insights into contemporary practice from the TRANSLATE-ACS study Eur Heart J Acute Cardiovasc Care 4 2015 499 508
38. L. De Luca, S. Leonardi, C. Cavallini, and et al. Contemporary antithrombotic strategies in patients with acute coronary syndrome admitted to cardiac care units in Italy: the EYESHOT Study Eur Heart J Acute Cardiovasc Care 4 2015 441 452
39. A. Bagai, Y. Wang, T.Y. Wang, and et al. In-Hospital switching between clopidogrel and prasugrel among patients with acute myocardial infarction treated with percutaneous coronary intervention. Insights into contemporary practice from the National Cardiovascular Data Registry Circ Cardiovasc Interv 7 2014 585 593
40. O. Angera, P. Hasvoldb, M. Thuressonc, and et al. Treatment pattern of contemporary dual antiplatelet therapies after acute coronary syndrome: a Swedish nationwide population-based cohort study Scand Cardiovasc J 11 2015 1 9
41. J.P. Loh, L.K. Pendyala, H. Kitabata, and et al. Safety of reloading prasugrel in addition to clopidogrel loading in patients with acute coronary syndrome undergoing percutaneous coronary intervention Am J Cardiol 111 2013 841 845
42. G. De Luca, M. Verdoia, A. Schaffer, and et al. Switching from high-dose clopidogrel to prasugrel in ACS patients undergoing PCI: a single-center experience J Thromb Thrombolysis 38 2014 388 394
43. M. Almendro-Delia, E. Blanco Ponce, R. Gomez-Domínguez, and et al. Safety and efficacy of in-hospital clopidogrel-to-prasugrel switching in patients with acute coronary syndrome. An analysis from the 'real world' J Thromb Thrombolysis 39 2015 499 507
44. G. Patti, E. Ricottini, L. De Luca, and et al. Safety and efficacy of switching from clopidogrel to prasugrel in patients undergoing percutaneous coronary intervention. A study-level meta-analysis from 15 studies J Cardiovasc Pharmacol 14 2016 [Epub ahead of print]
45. J. Chandrasekhar, N. Hibbert, M. Froeschl, and et al. on behalf of the CAPITAL investigators. The impact of switching P2Y12 receptor inhibitor therapy during index hospitalization: a systematic review Eur J Clin Pharmacol 72 2016 83 91