The promiscuous mineralocorticoid receptor

Hypertension

Volumn 67, Issue 5, 2016, Pages 839-840

  Funder, John W ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; COLLAGEN; CORTICOSTERONE; EPLERENONE; FIBRONECTIN; HYDROCORTISONE; LOSARTAN; MINERALOCORTICOID RECEPTOR; MINERALOCORTICOID ANTAGONIST;

BLOOD PRESSURE; BLOOD VESSEL INJURY; BODY WEIGHT; ENDOTHELIAL DYSFUNCTION; HUMAN; IN VIVO STUDY; KNOCKOUT RAT; MONOTHERAPY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RESISTANCE BLOOD VESSEL; SODIUM EXCRETION; VASCULAR REMODELING;

ALDOSTERONE; HUMANS; MINERALOCORTICOID RECEPTOR ANTAGONISTS; RECEPTORS, MINERALOCORTICOID;

EID: 84962368216     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.116.07180     Document Type: Note

References (7)

1. Briet M, Barhumi T, Mian MOR, Coelho SC, Ouerd S, Rautureau Y, Coffman TM, Paradis P, Schiffrin EL, Aldosterone-induced vascular remodelling and endothelial dysfunction require functional antiogensin type 1a receptors. Hypertension 2016;67:897-905. doi: 10.1161/HYPERTENSIONAHA.115.07074
2. Levy DG, Rocha R, Funder JW, Distinguishing the antihypertensive and electrolyte effects of eplerenone. J Clin Endocrinol Metab 2004 89 2736 2740. doi: 10.1210/jc.2003-032149
3. Funder JW, Physiology, pharmacology, toxicology and strength of materials. Mol Cell Endocrinol 1990 72 C53 C56
4. Shibata S, Rinehart J, Zhang J, Moeckel G, Castafieda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, Lifton RP, Mineralocorticoid phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metab 2013 18 660 671. doi: 10.1016/j.cmet.2013.10.005
5. Mihailidou AS, Loan Le TY, Mardini M, Funder JW, Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension 2009 54 1306 1312. doi: 10.1161/HYPERTENSIONAHA.109.136242
6. Chai W, Garrelds IM, Arulmani U, Schoemaker RG, Lamers JM, Danser AH, Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective? Br J Pharmacol 2005 145 664 671. doi: 10.1038/sj.bjp.0706220
7. Lam EY, Funder JW, Nikolic-Paterson DJ, Fuller PJ, Young MJ, Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats. Endocrinology 2006 147 3623 3629. doi: 10.1210/en.2005-1527