Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates

Chemistry - A European Journal

Volumn 18, Issue 3, 2012, Pages 857-868

  Maiti, Munmun ^a   Michielssens, Servaas ^b   Dyubankova, Natalia ^a   Maiti, Mohitosh ^a   Lescrinier, Eveline ^a   Ceulemans, Arnout ^b   Herdewijn, Piet ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

NMR spectroscopy; nucleosides; nucleotides; physicochemical properties; prodrugs

Indexed keywords

AMINO ACIDS; ATOMIC SPECTROSCOPY; ATOMS; CHEMICAL BONDS; CONFORMATIONS; KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDES; PROTONATION; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ACID MOIETY; AQUEOUS STABILITY; CARBOXYL ACID; CARBOXYL GROUPS; CHEMICAL HYDROLYSIS; CONFORMATIONAL STUDY; HYDROLYSIS REACTION; INTRAMOLECULAR CATALYSIS; KINETICS AND MECHANISM; NEUTRAL AQUEOUS SOLUTION; NUCLEOBASES; NUCLEOSIDES; NUCLEOTIDE ANALOGUES; P-O BONDS; PHOSPHORAMIDATES; PHYSICOCHEMICAL PROPERTIES; PRODRUGS; PROTONATED;

HYDROLYSIS;

EID: 84962359374     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201102279     Document Type: Article

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