Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 20, 2007, Pages 6574-6595

  Rzasa, Robert M ^a   Kaller, Matthew R ^a   Liu, Gang ^a   Magal, Ella ^a   Nguyen, Thomas T ^a   Osslund, Timothy D ^a   Powers, David ^a   Santora, Vincent J ^a   Viswanadhan, Vellarkad N ^a   Wang, Hui Ling ^a   Xiong, Xiaoling ^a   Zhong, Wenge ^a   Norman, Mark H ^a  

^a AMGEN INC   (United States)

Author keywords

3,4 Dihydro 1H quinazolin 2 one; CDK5; Kinase inhibitor; Neurodegenerative disorders

Indexed keywords

1 (2 PYRIDIN 4 YL THIAZOL 4 YL) 1,3 DIHYDRO BENZOIMIDAZOL 2 ONE; 3 (2 PYRIDIN 4 YL THIAZOL 4 YL) 1H QUINAZOLINE 2,4 DIONE; 3 [2 (2 ETHYL 4 PYRIDYL) 1,3 THIAZOL 4 YL] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 5 (4 METHYLPIPERAZIN 1 YL) 3 [2 (PYRIDIN 4 YL)THIAZOL 4 YL] 3,4 DIHYDROQUINAZOLIN 2(1H)ONE; 5 (MORPHOLIN 4 YL METHYL) 3 [2 (4 PYRIDYL)(1,3THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 5 BROMO 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 5 CHLORO 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 5 FLUORO 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 5 METHOXY 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 5 METHYL 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 6 (4 METHYLPIPERAZINYL) 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 6 FLUORO 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 6 METHYL 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 7 (MORPHOLIN 4 YL METHYL) 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 7 BROMO 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 7 FLUORO 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; 7 PHENYL 3 [2 (4 PYRIDYL)(1,3 THIAZOL 4 YL)] 1,3,4 TRIHYDROQUINAZOLIN 2 ONE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CRYSTALLOGRAPHY; DEREGULATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HUMAN;

EID: 84962359287     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.005     Document Type: Article

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