Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

Nature

Volumn 523, Issue 7558, 2015, Pages 111-114

  Webb, Bradley A ^a   Forouhar, Farhad ^b   Szu, Fu En ^b   Seetharaman, Jayaraman ^b   Tong, Liang ^b   Barber, Diane L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; PHOSPHATE; TETRAMER; RECOMBINANT PROTEIN;

CANCER; CATALYSIS; CRYSTAL STRUCTURE; DISEASE INCIDENCE; ENZYME ACTIVITY; GLUCOSE; HYDROLYSIS; METABOLITE; MUSCLE; MUTATION; PROTEIN;

ALLOSTERISM; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; GLYCOLYSIS; HUMAN; HYDROLYSIS; MALIGNANT NEOPLASTIC DISEASE; MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION; THROMBOCYTE; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR MODEL; NEOPLASM; PROTEIN TERTIARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

MAMMALIA; MUS; PYRONIA TITHONUS;

ENZYME ACTIVATION; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MUTATION; NEOPLASMS; PHOSPHOFRUCTOKINASE-1; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 84962355531     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14405     Document Type: Article

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