Impact of APOE-ɛ4 and family history of dementia on gray matter atrophy in cognitively healthy middle-aged adults

Neurobiology of Aging

Volumn 38, Issue , 2016, Pages 14-20

  ten Kate, Mara ^a   Sanz Arigita, Ernesto J ^b   Tijms, Betty M ^a   Wink, Alle Meije ^c   Clerigue, Montserrat ^b   Garcia Sebastian, Maite ^b   Izagirre, Andrea ^b   Ecay Torres, Miriam ^b   Estanga, Ainara ^b   Villanua, Jorge ^b,d   Vrenken, Hugo ^c   Visser, Pieter Jelle ^a,e   Martinez Lage, Pablo ^b   Barkhof, Frederik ^c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Foundation CITA Alzheimer   (Spain)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d HOSPITAL DONOSTIA   (Spain)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Alzheimer's disease; Apolipoprotein E; Dementia; Family history; MRI; Voxel based morphometry

Indexed keywords

APOLIPOPROTEIN E4;

ADULT; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; BRAIN REGION; COGNITION; COMMUNITY LIVING; CONTROLLED STUDY; CORPUS STRIATUM; DEMENTIA; FAMILY HISTORY; FEMALE; GRAY MATTER; HETEROZYGOTE; HUMAN; INSULA; MALE; MIDDLE AGED; PRECUNEUS; PRIORITY JOURNAL; RISK FACTOR; VOXEL BASED MORPHOMETRY; AGED; ATROPHY; GENETICS; PATHOLOGY;

AGED; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; ATROPHY; DEMENTIA; FEMALE; GRAY MATTER; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS;

EID: 84962318068     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.10.018     Document Type: Article

References (42)

1. Adroer R., Santacruz P., Blesa R., López-Pousa S., Ascaso C., Oliva R. Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases. Neurosci. Lett. 1995, 189:182-186.
2. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007, 38:95-113.
3. Berti V., Mosconi L., Glodzik L., Li Y., Murray J., De Santi S., Pupi A., Tsui W., De Leon M.J. Structural brain changes in normal individuals with a maternal history of Alzheimer's. Neurobiol. Aging 2011, 32:2325.e17-2325.e26.
4. Bertram L., Lill C.M., Tanzi R.E. The genetics of Alzheimer disease: back to the future. Neuron 2010, 68:270-281.
5. Blacker D., Haines J.L., Rodes L., Terwedow H., Go R.C.P., Harrell L.E., Perry R.T., Bassett S.S., Chase G., Meyers D., Albert M.S., Tanzi R. ApoE-4 and age at onset of Alzheimer's disease the NIMH genetics initiative. Neurology 1997, 48:139-147.
6. Blázquez L., De Juan D., Ruiz-Martínez J., Emparanza J.I., Sáenz A., Otaegui D., Sistiaga A., Martínez-Lage P., Lamet I., Samaranch L., Buiza C., Etxeberria I., Arriola E., Cuadrado E., Urdaneta E., Yanguas J., López de Munain A. Genes related to iron metabolism and susceptibility to Alzheimer's disease in Basque population. Neurobiol. Aging 2007, 28:1941-1943.
7. Bonthius D.J., Solodkin A., Van Hoesen G.W. Pathology of the insular cortex in Alzheimer disease depends on cortical architecture. J. Neuropathol. Exp. Neurol. 2005, 64:910-922.
8. Cherbuin N., Anstey K.J., Sachdev P.S., Maller J.J., Meslin C., Mack H.A., Wen W., Easteal S. Total and regional gray matter volume is not related to APOE-E4 status in a community sample of middle-aged individuals. J. Gerontol. A Biol. Sci. Med. Sci. 2008, 63:501-504.
9. Cohen R.M., Small C., Lalonde F., Friz J., Sunderland T. Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women. Neurology 2001, 57:2223-2228.
10. Den Heijer T., Oudkerk M., Launer L.J., van Duijn C.M., Hofman A., Breteler M.M.B. Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes. Neurology 2002, 59:746-748.
11. Donix M., Burggren A.C., Suthana N.A., Siddarth P., Ekstrom A.D., Krupa A.K., Jones M., Martin-Harris L., Ercoli L.M., Miller K.J., Small G.W., Bookheimer S.Y. Family history of Alzheimer's disease and hippocampal structure in healthy people. Am. J. Psychiatry 2010, 167:1399-1406.
12. Duara R., Barker W.W., Lopez-Alberola R., Loewenstein D.A., Grau L.B., Gilchrist D., Sevush S., George-Hyslop P.H.S. Alzheimer's disease interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset. Neurology 1996, 46:1575-1579.
13. Fazekas F., Chawluk J.B., Alavi A., Hurtig H.I., Zimmerman R.A. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJNR Am. J. Neuroradiol. 1987, 8:421-426.
14. Fratiglioni L., Ahlbom A., Viitanen M., Winblad B. Risk factors for late- onset Alzheimer's disease: a population- based, case-control study. Ann. Neurol. 1993, 33:258-266.
15. Geroldi C., Pihlajamäki M., Laakso M.P., DeCarli C., Beltramello A., Bianchetti A., Soininen H., Trabucchi M., Frisoni G.B. APOE-ε4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology 1999, 53:1825-1832.
16. Grahn J.A., Parkinson J.A., Owen A.M. The cognitive functions of the caudate nucleus. Prog. Neurobiol. 2008, 86:141-155.
17. Green R.C., Cupples L., Go R., Benke K.S., Edeki T., Griffith P.A., Williams M., Hipps Y., Graff-Radford N., Bachman D., Farrer L.A. Risk of dementia among white and African American relatives of patients with Alzheimer disease. JAMA 2002, 287:329-336. MIRAGE Study Group.
18. Honea R.A., Swerdlow R.H., Vidoni E.D., Goodwin J., Burns J.M. Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease. Neurology 2010, 74:113-120.
19. Honea R.A., Vidoni E., Harsha A., Burns J.M. Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study. J. Alzheimers Dis. 2009, 18:553-564.
20. Jack C.R., Knopman D.S., Jagust W.J., Petersen R.C., Weiner M.W., Aisen P.S., Shaw L.M., Vemuri P., Wiste H.J., Weigand S.D., Lesnick T.G., Pankratz V.S., Donohue M.C., Trojanowski J.Q. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013, 12:207-216.
21. Jak A.J., Houston W.S., Nagel B.J., Corey-Bloom J., Bondi M.W. Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults. Demen. Geriatr. Cogn. Disord. 2007, 23:382-389.
22. Karas G.B., Burton E.J., Rombouts S.A.R.B., van Schijndel R.A., O'Brien J.T., Scheltens P.H., McKeith I.G., Williams D., Ballard C., Barkhof F. A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry. Neuroimage 2003, 18:895-907.
23. Klunk W.E., Price J.C., Mathis C.A., Tsopelas N.D., Lopresti B.J., Ziolko S.K., Bi W., Hoge J.A., Cohen A.D., Ikonomovic M.D., Saxton J.A., Snitz B.E., Pollen D.A., Moonis M., Lippa C.F., Swearer J.M., Johnson K.A., Rentz D.M., Fischman A.J., Aizenstein H.J., DeKosky S.T. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J. Neurosci. 2007, 27:6174-6184.
24. Lind J., Larsson A., Persson J., Ingvar M., Nilsson L.G., Bäckman L., Adolfsson R., Cruts M., Sleegers K., Van Broeckhoven C., Nyberg L. Reduced hippocampal volume in non-demented carriers of the apolipoprotein E ɛ4: relation to chronological age and recognition memory. Neurosci. Lett. 2006, 396:23-27.
25. Liu Y., Paajanen T., Westman E., Wahlund L.O., Simmons A., Tunnard C., Sobow T., Proitsi P., Powell J., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S., Evans A., Spenger C., Lovestone S., Soininen H. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J. Alzheimers Dis. 2010, 21:947-966. AddNeuroMed Consortium.
26. Madsen S.K., Ho A.J., Hua X., Saharan P.S., Toga A.W., Jack C.R., Weiner M.W., Thompson P.M. 3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects. Neurobiol. Aging 2010, 31:1312-1325.
27. Moffat S.D., Szekely C.A., Zonderman A.B., Kabani N.J., Resnick S.M. Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology 2000, 55:134-136.
28. Möller C., Vrenken H., Jiskoot L., Versteeg A., Barkhof F., Scheltens P., van der Flier W.M. Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease. Neurobiol. Aging 2013, 34:2014-2022.
29. Mosconi L., Murray J., Tsui W.H., Li Y., Spector N., Goldowsky A., Williams S., Osorio R., McHugh P., Glodzik L., Vallabhajosula S., de Leon M.J. Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology 2014, 82:752-760.
30. Mueller S.G., SchuffN., Raptentsetsang S., Elman J., Weiner M.W. Selective effect of APOE e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T. Neuroimage 2008, 42:42-48.
31. Nieuwenhuys R. The insular cortex. Progress in Brain Research 2012, 123-163. Elsevier, New York. M. Hofman, D. Falk (Eds.).
32. Okonkwo O.C., Xu G., Dowling N.M., Bendlin B.B., LaRue A., Hermann B.P., Koscik R., Jonaitis E., Rowley H.A., Carlsson C.M., Asthana S., Sager M.A., Johnson S.C. Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology 2012, 78:1769-1776.
33. Reiter K., Alpert K.I., Cobia D.J., Kwasny M.J., Morris J.C., Csernansky J.C., Wang L. Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD. Neuroimage 2012, 61:525-532.
34. Rombouts S.A.R.B., Barkhof F., Witter M.P., Scheltens P. Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease. Neurosci. Lett. 2000, 285:231-233.
35. Sager M.A., Hermann B., Rue A.L. Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. J. Geriatr. Psychiatry Neurol. 2005, 18:245-249.
36. Schmidt C., WolffM., von Ahsen N., Zerr I. Alzheimer's disease: genetic polymorphisms and rate of decline. Dement. Geriatr. Cogn. Disord. 2012, 33:84-89.
37. Schmidt H., Schmidt R., Fazekas F., Semmler J., Kapeller P., Reinhart B., Kostner G.M. Apolipoprotein E4 allele in the normal elderly: neuropsychologic and brain MRI correlates. Clin. Genet. 1996, 50:293-299.
38. Spampinato M.V., Rumboldt Z., Hosker R.J., Mintzer J.E. Apolipoprotein E and gray matter volume loss in patients with mild cognitive impairment and Alzheimer disease. Radiology 2011, 258:843-852.
39. Van der Vlies A.E., Koedam E.L.G.E., Pijnenburg Y.A.L., Twisk J.W.R., Scheltens P., van der Flier W.M. Most rapid cognitive decline in APOE ε4 negative Alzheimer's disease with early onset. Psychol. Med. 2009, 39:1907-1911.
40. Van der Vlies A.E., Pijnenburg Y.A.L., Koene T., Klein M., Kok A., Scheltens P., van der Flier W.M. Cognitive impairment in Alzheimer's disease is modified by APOE genotype. Dement. Geriatr. Cogn. Disord. 2007, 24:98-103.
41. Wishart H.A., Saykin A.J., McAllister T.W., Rabin L.A., McDonald B.C., Flashman L.A., Roth R.M., Mamourian A.C., Tsongalis G.J., Rhodes C.H. Regional brain atrophy in cognitively intact adults with a single APOE ε4 allele. Neurology 2006, 67:1221-1224.
42. Wolk D.A., Dickerson B.C. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:10256-10261. Alzheimer's Disease Neuroimaging Initiative.