Deferred versus conventional stent implantation in patients with ST-segment elevation myocardial infarction (DANAMI 3-DEFER): An open-label, randomised controlled trial

The Lancet

Volumn 387, Issue 10034, 2016, Pages 2199-2206

  Kelbæk, Henning ^a   Høfsten, Dan Eik ^b   Køber, Lars ^b   Helqvist, Steffen ^b   Kløvgaard, Lene ^b   Holmvang, Lene ^b   Jørgensen, Erik ^b   Pedersen, Frants ^b   Saunamäki, Kari ^b   De Backer, Ole ^b   Bang, Lia E ^b   Kofoed, Klaus F ^b   Lønborg, Jacob ^b   Ahtarovski, Kiril ^b   Vejlstrup, Niels ^b   Bøtker, Hans E ^c   Terkelsen, Christian J ^c   Christiansen, Evald H ^c   Ravkilde, Jan ^d   Tilsted, Hans Henrik ^d   Villadsen, Anton B ^d   Aarøe, Jens ^d   Jensen, Svend E ^d   Raungaard, Bent ^d   Jensen, Lisette O ^e   Clemmensen, Peter ^f   Grande, Peer ^f   Madsen, Jan K ^b   Torp Pedersen, Christian ^b   Engstrøm, Thomas ^b   more..

^a ROSKILDE HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d AALBORG UNIVERSITY HOSPITAL   (Denmark)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f NYKØBING FALSTER HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; CARDIAC PATIENT; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR STENT; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CORONARY STENTING; DEFERRED STENT IMPLANTATION; DENMARK; FEMALE; FOLLOW UP; HEART LEFT BUNDLE BRANCH BLOCK; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE REVASCULARIZATION; HOSPITAL ADMISSION; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OPEN STUDY; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THROMBECTOMY; TRANSTHORACIC ECHOCARDIOGRAPHY; CLINICAL TRIAL; DRUG ELUTING STENT; MULTICENTER STUDY; MYOCARDIAL INFARCTION; PROCEDURES; VERY ELDERLY;

ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; AGED, 80 AND OVER; CALCIUM CHANNEL BLOCKERS; DRUG-ELUTING STENTS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PLATELET AGGREGATION INHIBITORS;

EID: 84962052950     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)30072-1     Document Type: Article

References (29)

1. S Windecker, P Kolh, F Alfonso for the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) 2014 ESC/EACTS guidelines on myocardial revascularization Eur Heart J 35 2014 2541 2619
2. PT O'Gara, FG Kushna, DD Ascheim et al. 2013 ACCF/AHA Guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 127 2013 529 555
3. R Jaffe, T Charron, G Puley, A Dick, BH Strauss Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention Circulation 117 2008 3152 3156
4. JP Henriques, F Zijlstra, JP Ottervanger et al. Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction Eur Heart J 23 2002 1112 1117
5. A Kaltoft, M Bøttcher, SS Nielsen et al. Routine thrombectomy in percutaneous coronary intervention for acute ST-segment-elevation myocardial infarction: a randomized, controlled trial Circulation 114 2006 40 47
6. H Kelbæk, CJ Terkelsen, S Helqvist et al. Randomized comparison of distal protection versus conventional treatment in primary percutaneous coronary intervention J Am Coll Cardiol 51 2008 899 905
7. PJ Vlaar, T Svlaas, IC van der Horst et al. Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study Lancet 371 2008 1915 1920
8. GW Stone, A Maehara, B Witzenbichler et al. Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction. The INFUSE-AMI randomized trial JAMA 307 2012 1817 1826
9. C Cafri, R Svirsky, J Zelinher et al. Improved procedural results in coronary thrombosis are obtained with delayedpercutaneous coronary interventions J Invasive Cadiol 16 2004 69 71
10. K Isaaz, C Robin, A Cerisier et al. A new approach of primary angioplasty for ST-elevation acute myocardial infacrtion based on minimalist immediate mechanical intervention Coron Artery Dis 17 2006 261 269
11. N Meneveau, MF Séronde, V Descotes-Genon et al. Immediate versus delayed angioplasty in infarct-related arteries with TIMI III flow and ST segment recovery: a matched comparison in acute myocardial infarction Clin Res Cardiol 98 2009 257 264
12. L Tang, SH Zhou, ZF Hu XQ Fang, XQ Shen Effect of delayed vs immediate stent implantation on myocardial perfusion and cardiac function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous intervention with thrombus aspiration Can J Cardiol 27 2011 541 547
13. D Ke, W Zhong, L Fan, L Chen Delayed verusus immediate stenting for the treatment of ST-elevation acute myocardial infarction with a high thrombus burden Coron Artery Dis 23 2012 497 506
14. H Kelbæk, T Engstrøm, KA Ahtarovski et al. Deferred stent implantation in patients with ST-segment elevation myocardial infarction: a pilot study EuroIntervention 8 2013 1126 1133
15. RH Mehta, KJ Harjai, DA Cox et al. Comparison of coronary stenting versus conventional balloon angioplasty on five-year mortality in patients with acute myocardial infarction undergoing primary percutaneous coronary ntervention Am J Cardiol 96 2005 901 906
16. H Suryapranata, G De Luca, AWJ van't Hof et al. Is routine stenting for acute myocardial infarction superiour to balloon angioplasty? A randomised comparison in a large cohort of unselected patients Heart 91 2005 641 645
17. T Engstrøm, H Kelbæk, S Helqvist et al. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3-PRIMULTI): an open-label, randomised controlled trial Lancet 386 2015 665 671
18. D Høfsten, H Kelbæk, S Helqvist et al. The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only. rationale and design of the DANAMI 3 trial program Am Heart J 169 2015 613 621
19. K Thygesen, JS Alpert, AS Jaffe et al. Third universal definition of myocardial infarction J Am Coll Cardiol 60 2012 1581 1598
20. ML Fokkema, PJ Vlaar, T Svilaas et al. Incidence and clinical consequences of distal embolization on the coronary angiogram after percutaneous coronary intervention for ST-elevation myocardial infarction Eur Heart J 30 2009 908 915
21. J Lønborg, H Kelbæk, S Helqvist et al. The impact of distal embolization and distal protection on long-term outcome in patients with ST elevation myocardial infarction randomized to primary percutaneous coronary intervention - results from a randomized study Eur Heart J Acute Cardiovasc Care 4 2015 180 188
22. G Sianos, MI Papafaklis, J Daemen et al. Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infaction J Am Coll Cardiol 50 2007 573 583
23. O Fröbert, B Lagerqvist, GK Olivecrona et al. Thrombus aspiration during ST-segment elevation myocardial infarction N Engl J Med 369 2013 1587 1597
24. SS Jolly, JA Cairns, S Yusuf et al. Randomized trial of primary PCI with or without routine manual thrombectomy N Engl J Med 372 2015 1389 1398
25. G Ndrepepa, K Tiroch, M Fusaro et al. 5-year prognostic value of no-flow phenomenon after percutaneous coronary intervention in patients with acute myocadial infarction J Am Coll Cardiol 55 2010 2383 2389
26. RW Harrison, A Aggarwal, FS Ou et al. American College of Cardiology National Cardiovascular Data Registry. Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction Am J Cardiol 111 2013 178 184
27. X Freixa, L Belle, L Joseph et al. Imediate vs delayed stenting in acute myocardial infarction: a systematic review and meta-analysis EuroIntervention 8 2013 1207 1216
28. D Carrick, KG Oldroyd, M McEntegart et al. A randomized trial of deferred stenting versus immediate stenting to prevent no- or slow-flow in acute ST-segment elevation myocardial infarction (DEFER-STEMI) J Am Coll Cardiol 63 2014 2088 2098
29. GD Perkins LallR T Quinn et al. Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial Lancet 385 2014 947 955