메뉴 건너뛰기




Volumn 13, Issue 2, 2016, Pages 93-95

Integration of genetic and epigenetic markers for risk stratification: Opportunities and challenges

Author keywords

cancer; epigenetics; polygenic risk; risk assessment; risk stratification

Indexed keywords

CELL DIVISION; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; ESOPHAGUS CANCER; GENE EXPRESSION; GENETICS; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; UTERINE CERVIX CANCER;

EID: 84962052772     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme.15.53     Document Type: Review
Times cited : (24)

References (21)
  • 1
    • 79955793051 scopus 로고    scopus 로고
    • Polygenic susceptibility to prostate and breast cancer: Implications for personalised screening
    • Pashayan N, Duffy SW, Chowdhury S et al. Polygenic susceptibility to prostate and breast cancer: implications for personalised screening. Br. J. Cancer 104(10), 1656-1663 (2011).
    • (2011) Br. J. Cancer , vol.104 , Issue.10 , pp. 1656-1663
    • Pashayan, N.1    Duffy, S.W.2    Chowdhury, S.3
  • 2
    • 84984985158 scopus 로고    scopus 로고
    • Combined associations of genetic and environmental risk factors: Implications for prevention of breast cancer
    • Garcia-Closas M, Gunsoy NB, Chatterjee N. Combined associations of genetic and environmental risk factors: implications for prevention of breast cancer. J. Natl Cancer Inst. 106(11), 1-6 (2014).
    • (2014) J. Natl Cancer Inst. , vol.106 , Issue.11 , pp. 1-6
    • Garcia-Closas, M.1    Gunsoy, N.B.2    Chatterjee, N.3
  • 3
    • 84942994349 scopus 로고    scopus 로고
    • Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis
    • Pashayan N, Duffy SW, Neal DE et al. Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis. Genet. Med. 17(10), 789-795 (2015).
    • (2015) Genet. Med. , vol.17 , Issue.10 , pp. 789-795
    • Pashayan, N.1    Duffy, S.W.2    Neal, D.E.3
  • 4
    • 84942991118 scopus 로고    scopus 로고
    • Reducing overdiagnosis by polygenic risk-stratified screening: Findings from the Finnish section of the ERSPC
    • Pashayan N, Pharoah PD, Schleutker J, Talala K, Tammela TL, Maattanen L et al. Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC. Br. J. Cancer 113, 1086-1093 (2015).
    • (2015) Br. J. Cancer , vol.113 , pp. 1086-1093
    • Pashayan, N.1    Pharoah, P.D.2    Schleutker, J.3    Talala, K.4    Tammela, T.L.5    Maattanen, L.6
  • 5
    • 84871572003 scopus 로고    scopus 로고
    • Time to revisit Geoffrey Rose: Strategies for prevention in the genomic era?
    • Burton H, Sagoo GS, Pharoah P, Zimmern RL. Time to revisit Geoffrey Rose: strategies for prevention in the genomic era? Ital. J. Public Health 9(4), e8665-1-e8665-9 (2012).
    • (2012) Ital. J. Public Health , vol.9 , Issue.4 , pp. e86651-e86659
    • Burton, H.1    Sagoo, G.S.2    Pharoah, P.3    Zimmern, R.L.4
  • 6
    • 84981334184 scopus 로고    scopus 로고
    • Stratified cancer screening: The practicalities of implementation
    • Dent T, Jbilou J, Rafi I et al. Stratified cancer screening: The practicalities of implementation. Public Health Genomics 16(3), 94-99 (2013).
    • (2013) Public Health Genomics , vol.16 , Issue.3 , pp. 94-99
    • Dent, T.1    Jbilou, J.2    Rafi, I.3
  • 7
    • 84871923658 scopus 로고    scopus 로고
    • Epigenetics makes its mark on women-specific cancers-an opportunity to redefine oncological approaches?
    • Widschwendter M, Jones A, Teschendorff AE. Epigenetics makes its mark on women-specific cancers-an opportunity to redefine oncological approaches? Gynecol. Oncol. 128(1), 134-143 (2013).
    • (2013) Gynecol. Oncol. , vol.128 , Issue.1 , pp. 134-143
    • Widschwendter, M.1    Jones, A.2    Teschendorff, A.E.3
  • 8
    • 84930926883 scopus 로고    scopus 로고
    • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
    • Michailidou K, Beesley J, Lindstrom S et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat. Genet. 47(4), 373-380 (2015).
    • (2015) Nat. Genet. , vol.47 , Issue.4 , pp. 373-380
    • Michailidou, K.1    Beesley, J.2    Lindstrom, S.3
  • 9
    • 78651445053 scopus 로고    scopus 로고
    • Genome-based prediction of breast cancer risk in the general population: A modeling study based on metaanalyses of genetic associations
    • van ZM, van der Net JB, Kundu S, Freedman AN, van Duijn CM, Janssens AC. Genome-based prediction of breast cancer risk in the general population: A modeling study based on metaanalyses of genetic associations. Cancer Epidemiol. Biomarkers Prev. 20(1), 9-22 (2011).
    • (2011) Cancer Epidemiol. Biomarkers Prev. , vol.20 , Issue.1 , pp. 9-22
    • Van, Z.M.1    Van Der Net, J.B.2    Kundu, S.3    Freedman, A.N.4    Van Duijn, C.M.5    Janssens, A.C.6
  • 10
    • 84873333241 scopus 로고    scopus 로고
    • Opportunities and challenges for selected emerging technologies in cancer epidemiology: Mitochondrial, epigenomic, metabolomic, and telomerase profiling
    • Verma M, Khoury MJ, Ioannidis JP. Opportunities and challenges for selected emerging technologies in cancer epidemiology: mitochondrial, epigenomic, metabolomic, and telomerase profiling. Cancer Epidemiol. Biomarkers Prev. 22(2), 189-200 (2013).
    • (2013) Cancer Epidemiol. Biomarkers Prev. , vol.22 , Issue.2 , pp. 189-200
    • Verma, M.1    Khoury, M.J.2    Ioannidis, J.P.3
  • 11
    • 0037068360 scopus 로고    scopus 로고
    • DNA methylation and breast carcinogenesis
    • Widschwendter M, Jones PA. DNA methylation and breast carcinogenesis. Oncogene 21(35), 5462-5482 (2002).
    • (2002) Oncogene , vol.21 , Issue.35 , pp. 5462-5482
    • Widschwendter, M.1    Jones, P.A.2
  • 12
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3(6), 415-428 (2002).
    • (2002) Nat. Rev. Genet. , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 13
    • 79960144202 scopus 로고    scopus 로고
    • Epigenetics: Principles and practice
    • Hamilton JP. Epigenetics: principles and practice. Dig. Dis. 29(2), 130-135 (2011).
    • (2011) Dig. Dis. , vol.29 , Issue.2 , pp. 130-135
    • Hamilton, J.P.1
  • 14
    • 84959334370 scopus 로고    scopus 로고
    • The role of epigenetics in genetic and environmental epidemiology
    • Epub ahead of print
    • Ladd-Acosta C, Fallin MD. The role of epigenetics in genetic and environmental epidemiology. Epigenomics doi:10.2217/epi.15.102 (2015) (Epub ahead of print).
    • (2015) Epigenomics
    • Ladd-Acosta, C.1    Fallin, M.D.2
  • 15
    • 84887054219 scopus 로고    scopus 로고
    • Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation
    • Herceg Z, Lambert MP, van Veldhoven K et al. Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis 34(9), 1955-1967 (2013).
    • (2013) Carcinogenesis , vol.34 , Issue.9 , pp. 1955-1967
    • Herceg, Z.1    Lambert, M.P.2    Van Veldhoven, K.3
  • 16
    • 84858828509 scopus 로고    scopus 로고
    • Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
    • Teschendorff AE, Jones A, Fiegl H et al. Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation. Genome Med. 4(3), 24 (2012).
    • (2012) Genome Med. , vol.4 , Issue.3 , pp. 24
    • Teschendorff, A.E.1    Jones, A.2    Fiegl, H.3
  • 17
    • 84905460448 scopus 로고    scopus 로고
    • The dynamics of DNA methylation covariation patterns in carcinogenesis
    • Teschendorff AE, Liu X, Caren H et al. The dynamics of DNA methylation covariation patterns in carcinogenesis. PLoS Comput. Biol. 10(7), e1003709 (2014).
    • (2014) PLoS Comput. Biol. , vol.10 , Issue.7 , pp. e1003709
    • Teschendorff, A.E.1    Liu, X.2    Caren, H.3
  • 18
    • 66249114998 scopus 로고    scopus 로고
    • A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus
    • Jin Z, Cheng Y, Gu W et al. A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus. Cancer Res. 69(10), 4112-4115 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.10 , pp. 4112-4115
    • Jin, Z.1    Cheng, Y.2    Gu, W.3
  • 19
    • 84994715829 scopus 로고    scopus 로고
    • Correlation of smoking-associated DNA methylation changes in buccal cells with DNA methylation changes in epithelial cancer
    • Teschendorff AE, Yang Z, Wong A et al. Correlation of smoking-associated DNA methylation changes in buccal cells with DNA methylation changes in epithelial cancer. JAMA Oncol. 1(4), 476-485 (2015).
    • (2015) JAMA Oncol. , vol.1 , Issue.4 , pp. 476-485
    • Teschendorff, A.E.1    Yang, Z.2    Wong, A.3
  • 20
    • 84902926542 scopus 로고    scopus 로고
    • A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival
    • Anjum S, Fourkala EO, Zikan M et al. A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. Genome Med. 6(6), 47 (2014).
    • (2014) Genome Med. , vol.6 , Issue.6 , pp. 47
    • Anjum, S.1    Fourkala, E.O.2    Zikan, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.