Research consent capacity varies with executive function and memory in Parkinson's disease

Movement Disorders

Volumn 31, Issue 3, 2016, Pages 414-417

  Moelter, Stephen T ^a   Weintraub, Daniel ^b,c   Mace, Lauren ^a   Cary, Mark ^c   Sullo, Elizabeth ^d   Xie, Sharon X ^c   Karlawish, Jason ^c,d  

^a UNIVERSITY OF THE SCIENCES   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Capacity; Cognitive impairment; Decision making; Informed consent; Parkinson's disease

Indexed keywords

ARTICLE; ASSESSMENT OF HUMANS; CLINICAL RESEARCH; COGNITION; CONTROLLED STUDY; DEMENTIA RATING SCALE 2; DEPTH PERCEPTION; EXECUTIVE FUNCTION; HUMAN; INFORMED CONSENT; MACARTHUR COMPETENCE ASSESSMENT; MAJOR CLINICAL STUDY; MEMORY; MENTAL CAPACITY; MENTAL PERFORMANCE; MONTREAL COGNITIVE ASSESSMENT; PARKINSON DISEASE; PATIENT DECISION MAKING; PATIENT PARTICIPATION; PRIORITY JOURNAL; RECALL; STRUCTURED INTERVIEW; COGNITIVE DEFECT; COMPLICATION; DECISION MAKING; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; RESEARCH;

COGNITION DISORDERS; DECISION MAKING; EXECUTIVE FUNCTION; HUMANS; MEMORY; NEUROPSYCHOLOGICAL TESTS; PARKINSON DISEASE; RESEARCH;

EID: 84962033893     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26469     Document Type: Article

References (15)

1. Weintraub D, Doshi J, Koka D, et al. Neurodegeneration across stages of cognitive decline in Parkinson disease. Arch Neurol 2011;68:1562-1568.
2. Troster AI, Troster AI. Neuropsychological characteristics of dementia with Lewy bodies and Parkinson's disease with dementia: differentiation, early detection, and implications for "mild cognitive impairment" and biomarkers. Neuropsychol Rev 2008;18:103-119.
3. Litvan I, Aarsland D, Adler CH, et al. MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI. Mov Disord 2011;26:1814-1824.
4. Karlawish J, Cary M, Moelter ST, et al. Cognitive impairment and PD patients' capacity to consent to research. Neurology 2013;81:801-807.
5. Dirnberger G, Jahanshahi M. Executive dysfunction in Parkinson's disease. J Neuropsychol 2013;7:193-224.
6. Appelbaum PS, Grisso T. The MacArthur Competence Assessment Tool-Clinical Research. Sarasota, FL: Professional Resource Press; 2000.
7. Jurica PJ, Leitten CL, Mattis S. Dementia Rating Scale-2 (DRS-2) Professional Manual. Lutz, FL: Psychological Assessment Resources, Inc.; 2001.
8. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005;53:695-699.
9. Karlawish JH, Casarett DJ, James BD. Alzheimer's disease patients' and caregivers' capacity, competency, and reasons to enroll in an early-phase Alzheimer's disease clinical trial. J Am Geriatr Soc 2002;50:2019-2024.
10. Rubright J, Sankar P, Casarett DJ, Gur R, Xie SX, Karlawish J. A memory and organizational aid improves Alzheimer disease research consent capacity: results of a randomized, controlled trial. Am J Geriatr Psychiatry 2010;18:1124-1132.
11. Karlawish J, Kim SY, Knopman D, et al. Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trials. Am J Geriatr Psychiatry 2008;16:568-574.
12. Kim SY, Appelbaum PS, Kim HM, et al. Variability of judgments of capacity: experience of capacity evaluators in a study of research consent capacity. Psychosomatics 2011;52:346-353.
13. Kudlicka A, Clare L, Hindle JV. Executive functions in Parkinson's disease: systematic review and meta-analysis. Mov Disord 2011;26:2305-2315.
14. Martin RC, Okonkwo OC, Hill J, et al. Medical decision-making capacity in cognitively impaired Parkinson's disease patients without dementia. Mov Disord 2008;23:1867-1874.
15. Kudlicka A, Clare L, Hindle JV. Awareness of executive deficits in people with Parkinson's disease. J Int Neuropsychol Soc 2013;19:559-570.