A case of relapsing and refractory catastrophic anti-phospholipid syndrome successfully managed with eculizumab, a complement 5 inhibitor

Rheumatology (United Kingdom)

Volumn 55, Issue 2, 2015, Pages 382-384

  Wig, Surabhi ^a   Chan, Marian ^b   Thachil, Jecko ^a   Bruce, Ian ^a,c,d   Barnes, Theresa ^b  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^b Countess of Chester Hospital NHS Foundation Trust ^*  (United Kingdom)

^c Institute of Inflammation and Repair   (United Kingdom)

^d MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTIHYPERTENSIVE AGENT; AZATHIOPRINE; BLOOD CLOTTING FACTOR 10A; C REACTIVE PROTEIN; CYCLOPHOSPHAMIDE; ECULIZUMAB; FIBRINOGEN; IMMUNOGLOBULIN; LOW MOLECULAR WEIGHT HEPARIN; MENINGOCOCCUS VACCINE; METHYLPREDNISOLONE; PREDNISOLONE; RITUXIMAB; VITAMIN K GROUP; WARFARIN;

ABDOMINAL PAIN; ACUTE KIDNEY FAILURE; ACUTE LIVER FAILURE; ADULT; ANTIBIOTIC PROPHYLAXIS; ANTICOAGULATION; ANTIPHOSPHOLIPID SYNDROME; BRAIN HEMORRHAGE; CASE REPORT; CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME; DRUG DOSE REDUCTION; DRUG EFFICACY; EPIGASTRIC PAIN; EPILEPTIC STATE; FEMALE; FEVER; HUMAN; HUMAN TISSUE; HYPERTENSION; INTERNATIONAL NORMALIZED RATIO; KIDNEY BIOPSY; LARGE VESSEL VASCULITIS; LETTER; MENINGOCOCCOSIS; MORBIDITY; OCCLUSIVE CEREBROVASCULAR DISEASE; PLASMAPHERESIS; PREGNANCY; PRIORITY JOURNAL; PROTEINURIA; RELAPSE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT OUTCOME; UPPER EXTREMITY DEEP VEIN THROMBOSIS; VASCULITIS;

EID: 84961960857     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kev371     Document Type: Letter

References (3)

1. Cervera R, Espinosa G. Update on the catastrophic antiphospholipid syndrome and the "CAPS Registry". Semin Thromb Hemost 2012;38:333-8.
2. Shapira I, Andrade D, Allen SL, Salmon JE. Brief report: induction of sustained remission in recurrent catastrophic antiphospholipid syndrome via inhibition of terminal complement with eculizumab. Arthritis Rheum 2012;64: 2719-23.
3. Strakhan M, Hurtado-Sbordoni M, Galeas N et al. 36 yearold female with catastrophic antiphospholipid syndrome treated with eculizumab: a case report and review of literature. Case Rep Hematol 2014;2014:704371.