Plasma from pre-eclamptic patients induces the expression of the anti-angiogenic miR-195-5p in endothelial cells

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 6, 2016, Pages 1198-1200

  Sandrim, Valeria Cristina ^a   Dias, Mayara Caldeira ^a   Bovolato, Ana Lívia de Carvalho ^a   Tanus Santos, Jose E ^b   Deffune, Elenice ^a   Cavalli, Ricardo C ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiogenesis; HUVECs; MicroRNA; MiR 195; Pre eclampsia; VEGF

Indexed keywords

MICRORNA; MICRORNA 195 5P; UNCLASSIFIED DRUG; VASCULOTROPIN A; ANGIOGENESIS INHIBITOR; MIRN195 MICRORNA, HUMAN;

ADULT; ANTIANGIOGENIC ACTIVITY; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; NOTE; PLASMA; PREECLAMPSIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANGIOGENESIS; BLOOD; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PREGNANCY;

ADULT; ANGIOGENESIS INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; PRE-ECLAMPSIA; PREGNANCY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84961637069     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12767     Document Type: Note

References (14)

1. Wang R, Zhao N, Li S, et al. MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42. Hepatology. 2013; 58: 642-53.
2. Wang A, Rana S, Karumanchi SA. Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda). 2009; 24: 147-58.
3. Hu Y, Li P, Hao S, et al. Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia. Clin Chem Lab Med. 2009; 47: 923-9.
4. Shah DA, Khalil RA. Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. Biochem Pharmacol. 2015; 95: 211-26.
5. Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003; 111: 649-58.
6. Roberts JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998; 16: 5-15.
7. Brennan LJ, Morton JS, Davidge ST. Vascular dysfunction in preeclampsia. Microcirculation. 2014; 21: 4-14.
8. Goulopoulou S, Davidge ST. Molecular mechanisms of maternal vascular dysfunction in preeclampsia. Trends Mol Med. 2015; 21: 88-97.
9. Mackenzie R, Sandrim VC, Carty DM, et al. Endothelial Fos expression and preeclampsia. BJOG. 2012; 119: 1564.
10. Calicchio R, Buffat C, Mathieu JR, et al. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells. Am J Pathol. 2013; 183: 1993-2006.
11. de Groot CJ, Murai JT, Vigne JL, et al. Eicosanoid secretion by human endothelial cells exposed to normal pregnancy and preeclampsia plasma in vitro. Prostaglandins Leukot Essent Fatty Acids. 1998; 58: 91-7.
12. Wu CF, Huang FD, Sui RF, et al. Preeclampsia serum upregulates CD40/CD40L expression and induces apoptosis in human umbilical cord endothelial cells. Reprod Biol Endocrinol. 2012; 10: 28.
13. Scalera F, Schlembach D, Beinder E. Production of vasoactive substances by human umbilical vein endothelial cells after incubation with serum from preeclamptic patients. Eur J Obstet Gynecol Reprod Biol. 2001; 99: 172-8.
14. Kiprono LV, Wallace K, Moseley J, et al. Progesterone blunts vascular endothelial cell secretion of endothelin-1 in response to placental ischemia. Am J Obstet Gynecol. 2013; 209: 44.e1-6.