Single-dose tranexamic acid for reducing bleeding and transfusions in total hip arthroplasty: A double-blind, randomized controlled trial of different doses

Thrombosis Research

Volumn 141, Issue , 2016, Pages 119-123

  Wang, Changde ^a,b   Kang, Pengde ^a   Ma, Jun ^a   Yue, Chen ^a   Xie, Jinwei ^a   Pei, Fuxing ^a  

^a SICHUAN UNIVERSITY   (China)

^b NORTH MINZU UNIVERSITY   (China)

Author keywords

Bleeding; Deep vein thrombosis; Single dose; Tranexamic acid; Transfusion

Indexed keywords

ENOXAPARIN; HEMOGLOBIN; PLACEBO; RIVAROXABAN; TRANEXAMIC ACID; ANTICOAGULANT AGENT; ANTIFIBRINOLYTIC AGENT; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; ASYMPTOMATIC DISEASE; B SCAN; BLOOD TRANSFUSION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED PRACTICE; FEMALE; HEMATOCRIT; HEMATOMA; HEPARINIZATION; HUMAN; LOWER EXTREMITY DEEP VEIN THROMBOSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE DRUG DOSE; OPERATIVE BLOOD LOSS; PARALLEL DESIGN; PILOT STUDY; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; POSTOPERATIVE THROMBOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REAL TIME ULTRASOUND SCANNER; SINGLE DRUG DOSE; SURGICAL INFECTION; SURGICAL PATIENT; THROMBOSIS PREVENTION; TOTAL HIP PROSTHESIS; TREATMENT OUTCOME; WOUND FLUID; ADVERSE EFFECTS; BLOOD LOSS, SURGICAL; HIP REPLACEMENT; VENOUS THROMBOSIS;

ANTICOAGULANTS; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; MALE; POSTOPERATIVE HEMORRHAGE; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 84961566757     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2016.02.027     Document Type: Article

References (25)

1. B.E. Bierbaum, J.J. Callaghan, J.O. Galante, and et al. An analysis of blood management in patients having a total hip or knee arthroplasty J. Bone Joint Surg. Am. 81 1 1999 2 10
2. S. Yamasaki, K. Masuhara, and T. Fuji Tranexamic acid reduces postoperative blood loss in cementless total hip arthroplasty J. Bone Joint Surg. Am. 87 4 2005 766 770
3. G. Konig, B.R. Hamlin, J.H. Waters, and et al. Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty J. Arthroplast. 28 9 2013 1473 1476
4. P.M. Mannucci Hemostatic drugs N. Engl. J. Med. 339 4 1998 245 253
5. S. Yamasaki, K. Masuhara, and T. Fuji Preoperative administration of tranexamic acid reduces postoperative blood loss in cementless total hip arthroplasty: Paired study in 12 cases Hip Joint 30 2004 535 537
6. C.D. Krohn, O. Reikerås, S. Bjørnsen, and et al. Fibrinolytic activity and postoperative salvaged untreated blood for autologous transfusion in major orthopaedic surgery Eur. J. Surg. 167 3 2001 168 172
7. M.A. Claeys, N. Vermeersch, and P. Haentjens Reduction of blood loss with tranexamic acid in primary total hip replacement surgery Acta Chir. Belg. 107 4 2007 397 401
8. G. Benoni, H. Fredin, R. Knebel, and et al. Blood conservation with tranexamic acid in total hip arthroplasty: a randomized, double-blind study in 40 primary operations Acta Orthop. Scand. 72 5 2001 442 448
9. T. Johansson, L.G. Pettersson, and B. Lisander Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients Acta Orthop. 76 3 2005 314 319
10. S. Jamie McConnell, Sandeep Shewale.Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray A randomized controlled trial Acta Orthop. 82 6 2011 660 663
11. S.M. Kazemi, F. Mosaffa, A. Eajazi, and et al. The effect of tranexamic acid on reducing blood loss in cementless total hip arthroplasty under epidural anesthesia Orthopedics 33 1 2010 17
12. J. Singh, M.S. Ballal, P. Mitchell, and et al. Effects of tranexamic acid on blood loss during total hip arthroplasty J. Orthop. Surg. (Hong Kong) 18 3 2010 282 286
13. R. Malhotra, V. Kumar, and B. Garg The use of tranexamic acid to reduce blood loss in primary cementless total hip arthroplasty Eur. J. Orthop. Surg. Traumatol. 21 2 2011 101 104
14. N. Garneti, and J. Field Bone bleeding during total hip arthroplasty after administration of tranexamic acid J. Arthroplast. 19 4 2004 488 492
15. G. Ekbäck, K. Axelsson, L. Ryttberg, and et al. Tranexamic acid reduces blood loss in total hip replacement surgery Anesth. Analg. 91 5 2000 1124 1130
16. K. Ido, M. Neo, Y. Asada, and et al. Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties Arch. Orthop. Trauma Surg. 120 9 2000 518 520
17. S. Yamasaki, K. Masuhara, and T. Fuji Tranexamic acid reduces blood loss after cementless total hip arthroplasty prospective randomized study in 40 cases Int. Orthop. 28 2 2004 69 73
18. Clave A, Fazilleau F, Dumser D, et al. Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: a case-control study in 70 patients. Orthop. Traumatol. Surg. Res. 2012;98(5):484-90
19. G. Benoni, S. Lethagen, P. Nilsson, and et al. Tranexamic acid, given at the end of the operation, does not reduce post -operative blood loss in hip arthroplasty Acta Orthop. Scand. 71 3 2009 250 254
20. K. Rajesparan, L.C. Biant, M. Ahmad, and et al. The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement J. Bone Joint Surg. (Br.) 91 6 2009 776 783
21. J.B. Gross Estimating allowable blood loss: corrected for dilution Anaesthesiology 58 3 1983 277 280
22. Xudong Liu, Xianlong Zhang, Yunsu Chen, and et al. Hidden blood loss after total hip arthroplasty J. Arthroplast. 26 7 2011 1100 1105
23. J. Cid, and M. Lozano Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials Transfusion 45 8 2005 1302 1307
24. C.L. Barnes, C.L. Nelson, M.L. Nix, and et al. Duplex scanning versus venography as a screening examination in total hip arthroplasty patients Clin. Orthop. Relat. Res. 271 1991 180 189
25. J.C. Grady-Benson, C.S. Oishi, P.B. Hanson, and et al. Rountion postoperative duplex ultrosonography screening and monitoring for the detection of deep vein thrombosis Clin. Orthop. Relat. Res. 307 1994 130 141