Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics

Journal of Molecular Biology

Volumn 428, Issue 1, 2016, Pages 194-205

  Ataie, Niloufar ^a   Xiang, Jingyi ^b   Cheng, Neal ^b   Brea, Elliott J ^c   Lu, Wenjie ^a   Scheinberg, David A ^c,d   Liu, Cheng ^b   Ng, Ho Leung ^a,e  

^a UNIVERSITY OF HAWAII   (United States)

^b EUREKA THERAPEUTICS   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Abbreviations TCR T cell receptor; B2M 2 microglobulin; CDR complementarity determining region; mAb monoclonal antibody; MHC major histocompatibility complex; NIH National Institutes of Health; pMHC peptide MHC; SSRL Stanford Synchrotron Radiation Laboratory; TCRm TCR mimic

Indexed keywords

HLA A ANTIGEN; ONCOPROTEIN; ANTIBODY; ANTINEOPLASTIC AGENT; HLA A2 ANTIGEN; HLA-A*02 ANTIGEN; PROTEIN BINDING; WT1 PROTEIN; WT1 PROTEIN, HUMAN;

ANIMAL CELL; ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG TARGETING; FEMALE; HLA SYSTEM; HUMAN; IMMUNOTHERAPY; NEPHROBLASTOMA; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; PURIFICATION; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR MODEL; MOUSE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; HLA-A2 ANTIGEN; HUMANS; MICE; MODELS, MOLECULAR; PHARMACOGENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; WT1 PROTEINS;

EID: 84961342453     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.12.002     Document Type: Article

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