IBD pathogenesis in 2014: Molecular pathways controlling barrier function in IBD

Nature Reviews Gastroenterology and Hepatology

Volumn 12, Issue 2, 2015, Pages 67-68

  Atreya, Raja ^a   Neurath, Markus F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CD1D ANTIGEN; GAMMA INTERFERON; HEAT SHOCK PROTEIN 110; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 6; INTERLEUKIN 9; INTERLEUKIN 9 RECEPTOR; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 1; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE;

ANTIGEN EXPRESSION; APOPTOSIS; CELL DEATH; CELL SURVIVAL; CROHN DISEASE; ENTERITIS; ENZYME ACTIVITY; GENE ACTIVATION; HUMAN; INTESTINE EPITHELIUM CELL; INTESTINE FUNCTION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ULCERATIVE COLITIS; GENETICS; HOMEOSTASIS; INFLAMMATORY BOWEL DISEASE; INTESTINE ABSORPTION; INTESTINE MUCOSA; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; TRANSLATIONAL RESEARCH; TRENDS;

CYTOKINES; HOMEOSTASIS; HUMANS; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84961297792     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2014.201     Document Type: Review

References (10)

1. Takahashi, N. et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature 513, 95-99 (2014).
2. Olszak, T. et al. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509, 497-502 (2014).
3. Fuss, I. J. et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113, 1490-1497 (2004).
4. Shouval, D. S. et al. Interleukin-10 receptor signalling in innate immune cells regulates mucosal immune tolerance and antiinflammatory macrophage function. Immunity 40, 706-719 (2014).
5. Davison, N. J. et al. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J. Exp. Med. 184, 241-251 (1996).
6. Neurath, M. F. Cytokines in inflammatory bowel disease. Nat. Rev. Immunol. 14, 329-342 (2014).
7. Gerlach, K. et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signalling in intestinal epithelial cells. Nat. Immunol. 15, 676-686 (2014).
8. Leushacke, M. et al. Ex vivo culture of the intestinal epithelium: strategies and applications. Gut 63, 1345-1354 (2014).
9. Turgeon, N. et al. The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 306, 594-605 (2014).
10. Chassaing, B. et al. Intestinal epithelial cell Toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2014.08.033.