The lifestyle of memory CD8+ T cells

Nature Reviews Immunology

Volumn 16, Issue 4, 2016, Pages 271-

  Alp, Özen Sercan ^a   Radbruch, Andreas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 7; KI 67 ANTIGEN; KRUPPEL LIKE FACTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; UNCLASSIFIED DRUG;

BONE MARROW STROMA CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE G1 PHASE; CELL DEATH; CELL MOTILITY; CELL SURVIVAL; HOMEOSTASIS; HUMAN; IMMUNOLOGICAL MEMORY; LETTER; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PARABIOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BONE MARROW CELL; IMMUNOLOGY;

ANIMALS; BONE MARROW CELLS; HUMANS; IMMUNOLOGIC MEMORY;

EID: 84961275798     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.32     Document Type: Letter

References (16)

1. Tokoyoda, K., Hauser, A. E., Nakayama, T. & Radbruch, A. Organization of immunological memory by bone marrow stroma. Nat. Rev. Immunol. 10, 193-200 (2010).
2. Di Rosa, F. Maintenance of memory T cells in the bone marrow: survival or homeostatic proliferation? Nat. Rev. Immunol. (2016).
3. Parretta, E. et al. CD8 cell division maintaining cytotoxic memory occurs predominantly in the bone marrow. J. Immunol. 174, 7654-7664 (2005).
4. Becker, T. C., Coley, S. M., Wherry, E. J. & Ahmed, R. Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. J. Immunol. 174, 1269-1273 (2005).
5. Parretta, E. et al. Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2′-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow. J. Immunol. 180, 7230-7239 (2008).
6. Choo, D. K., Murali-Krishna, K., Anita, R. & Ahmed, R. Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. J. Immunol. 185, 3436-3444 (2010).
7. Tokoyoda, K. et al. Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity 30, 721-730 (2009).
8. Shinoda, K. et al. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl Acad. Sci. USA 109, 7409-7414 (2012).
9. Okhrimenko, A. et al. Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory. Proc. Natl Acad. Sci. USA 111, 9229-9234 (2014).
10. Sercan Alp, O. et al. Memory CD8+ T cells colocalize with IL-7+ stromal cells in bone marrow and rest in terms of proliferation and transcription. Eur. J. Immunol. 45, 975-987 (2015).
11. Pabst, R., Miyasaka, M. & Dudler, L. Numbers and phenotype of lymphocytes emigrating from sheep bone marrow after in situ labelling with fluorescein isothiocyanate. Immunology 59, 217-222 (1986).
12. Klonowski, K. D. et al. Dynamics of blood-borne CD8 memory T cell migration in vivo. Immunity 20, 551-562 (2004).
13. Schenkel, J. M., Fraser, K. A. & Masopust, D. Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs. J. Immunol. 192, 2961-2964 (2014).
14. Laidlaw, B. J. et al. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity 41, 633-645 (2014).
15. Mazzucchelli, R. I. et al. Visualization and identification of IL-7 producing cells in reporter mice. PLoS ONE 4, e7637 (2009).
16. Geerman, S., Hickson, S., Brasser, G., Pascutti, M. F. & Nolte, M. A. Quantitative and qualitative analysis of bone marrow CD8+ T cells from different bones uncovers a major contribution of the bone marrow in the vertebrae. Front. Immunol. 6, 660 (2015).