The Potential Role of GnRH Agonists and Antagonists in Inducing Thyroid Physiopathological Changes during IVF

Reproductive Sciences

Volumn 23, Issue 4, 2016, Pages 515-523

  Gizzo, Salvatore ^a   Noventa, Marco ^a   Quaranta, Michela ^b   Vitagliano, Amerigo ^a   Esposito, Federica ^a   Andrisani, Alessandra ^a   Venturella, Roberta ^c   Alviggi, Carlo ^d   Plebani, Mario ^e   Gangemi, Michele ^a   Nardelli, Giovanni Battista ^a   D'Antona, Donato ^a  

^a Azienda Ospedaliero Universitaria   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

controlled ovarian stimulation; GnRH antagonist; IVF outcome; pregnancy rate; thyroid autoimmunity; thyroid function; thyroid stimulating hormone

Indexed keywords

CETRORELIX; CHORIONIC GONADOTROPIN; FOLLITROPIN; MUELLERIAN INHIBITING FACTOR; PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; THYROID ANTIBODY; THYROTROPIN; THYROXINE; TRIPTORELIN; GONADORELIN; HORMONE ANTAGONIST;

ANTIBODY BLOOD LEVEL; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FOLLITROPIN BLOOD LEVEL; HUMAN; HYPOTHALAMUS; HYPOTHYROIDISM; INTRACYTOPLASMIC SPERM INJECTION; LUTEAL PHASE; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; OOCYTE RETRIEVAL; OVULATION INDUCTION; PREGNANCY RATE; PRIORITY JOURNAL; THYROID FUNCTION; THYROID GLAND; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; ADULT; ADVERSE EFFECTS; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BLOOD; IN VITRO FERTILIZATION; INFERTILITY, FEMALE; METABOLISM; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY OUTCOME; TRENDS;

ADULT; COHORT STUDIES; FEMALE; FERTILIZATION IN VITRO; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; INFERTILITY, FEMALE; PREGNANCY; PREGNANCY OUTCOME; THYROID GLAND; THYROTROPIN; TRIPTORELIN PAMOATE;

EID: 84961242806     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719115608000     Document Type: Article

References (30)

1. Gizzo S, Andrisani A, Esposito F, et al. Ovarian reserve test: an impartial means to resolve the mismatch between chronological and biological age in the assessment of female reproductive chances. Reprod Sci. 2014; 21 (5): 632-639.
2. Vitagliano A, Quaranta M, Noventa M, Gizzo S,. "Empiric" inositol supplementation in normal-weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Arch Gynecol Obstet. 2015; 291 (5): 955-957.
3. Gizzo S, Capuzzo D, Zicchina C, et al. Could empirical low-dose-aspirin administration during IVF cycle affect both the oocytes and embryos quality via COX 1-2 activity inhibition? J Assist Reprod Genet. 2014; 31 (3): 261-268.
4. Vitagliano A, Noventa M, Gizzo S,. Emerging evidence regarding statins use as novel endometriosis targeted treatment: real "magic pills" or "trendy" drugs? Some considerations. Eur J Obstet Gynecol Reprod Biol. 2015; 184: 125-126.
5. Mintziori G, Goulis DG, Toulis KA, Venetis CA, Kolibianakis EM, Tarlatzis BC,. Thyroid function during ovarian stimulation: a systematic review. Fertil Steril. 2011; 96 (3): 780-785.
6. Benaglia L, Busnelli A, Somigliana E, et al. Incidence of elevation of serumthyroid-stimulatinghormoneduringcontrolledovarianhyperstimulation for in vitro fertilization. Eur J Obstet Gynecol Reprod Biol. 2014; 173: 53-57.
7. La Rosa S, Celato N, Uccella S, Capella C,. Detection of gonadotropin-releasing hormone receptor in normal human pituitary cells and pituitary adenomas using immunohistochemistry. Virchows Arch. 2000; 437 (3): 264-269.
8. Hong IS, Klausen C, Cheung AP, Leung PC,. Gonadotropin-releasing hormone-I or -II interacts with IGF-I/Akt but not connexin 43 in human granulosa cell apoptosis. J Clin Endocrinol Metab. 2012; 97 (2): 525-534.
9. Tan O, Carr BR, Beshay VE, Bukulmez O,. The extrapituitary effects of GnRH antagonists and their potential clinical implications: a narrated review. Reprod Sci. 2013; 20 (1): 16-25.
10. Han EJ, Song HD, Yang JH, et al. Thyroid dysfunction associated with administration of the long-acting gonadotropin-releasing hormone agonist. Endocrinol Metab (Seoul). 2013; 28 (3): 221-225.
11. Rizvi T, Rehm PK,. Recombinant human thyrotropin use resulting in ovarian hyperstimulation: an unusual side effect. Eur Thyroid J. 2014; 3 (2): 125-129.
12. Aghajanova L, Lindeberg M, Carlsson IB, et al. Receptors for thyroid-stimulating hormone and thyroid hormones in human ovarian tissue. Reprod Biomed Online. 2009; 18 (3): 337-347.
13. Orvieto R,. GnRH agonist versus GnRH antagonist in ovarian stimulation: has the ongoing debate resolved? Reprod Biomed Online. 2014; 29 (5): 647-649.
14. Gizzo S, Andrisani A, Noventa M, et al. Menstrual cycle length: a surrogate measure of reproductive health capable of improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART. Reprod Biol Endocrinol. 2015; 13: 28.
15. Patrelli TS, Berretta R, Gizzo S, et al. CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate. Fertil Steril. 2011; 95 (1): 393-396.
16. Gizzo S, Patrelli TS, Rossanese M, et al. An update on diabetic women obstetrical outcomes linked to preconception and pregnancy glycemic profile: a systematic literature review. ScientificWorld J. 2013; 2013: 254901.
17. Saccardi C, Conte L, Fabris A, et al. Hysteroscopic enucleation in toto of submucous type 2 myomas: long-term follow-up in women affected by menorrhagia. Minim Invasive Gynecol. 2014; 21 (3): 426-430.
18. Litta P, Cosmi E, Saccardi C, Esposito C, Rui R, Ambrosini G,. Outpatient operative polypectomy using a 5 mm-hysteroscope without anaesthesia and/or analgesia: advantages and limits. Eur J Obstet Gynecol Reprod Biol. 2008; 139 (2): 210-214.
19. Vitagliano A, Noventa M, Gizzo S,. Is it time to consider patients suffering from endometriosis-related infertility as "novel candidates" for targeted peri-conceptional D-chiro inositol supplementation? Hypothesis, rationale and some considerations. J Assist Reprod Genet. 2015; 32 (3): 407-408.
20. Gizzo S, Andrisani A, Esposito F, et al. Which luteal phase support is better for each IVF stimulation protocol to achieve the highest pregnancy rate? A superiority randomized clinical trial [published online September 30, 2014]. Gynecol Endocrinol. 2014: 1-7.
21. Gracia CR, Morse CB, Chan G, et al. Thyroid function during controlled ovarian hyperstimulation as part of in vitro fertilization. Fertil Steril. 2012; 97 (3): 585-591.
22. Poppe K, Glinoer D, Tournaye H, Schiettecatte J, Haentjens P, Velkeniers B,. Thyroid function after assisted reproductive technology in women free of thyroid disease. Fertil Steril. 2005; 83 (6): 1753-1757.
23. Kutteh WH, Yetman DL, Carr AC, Beck LA, Scott RT Jr,. Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction. Fertil Steril. 1999; 71 (5): 843-848.
24. Baloch Z, Carayon P, Conte-Devolx B, et al. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003; 13 (1): 3-126.
25. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291 (2): 228-238.
26. Ghosh BR, Wu JC, Strahl BD, Childs GV, Miller WL,. Inhibin and estradiol alter gonadotropes differentially in ovine pituitary cultures: changing gonadotrope numbers and calcium responses to gonadotropin-releasing hormone. Endocrinology. 1996; 137 (11): 5144-5154.
27. Millar R, Lowe S, Conklin D, et al. A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc Natl Acad Sci U S A. 2001; 98 (17): 9636-9641.
28. Krsmanovic LZ, Martinez-Fuentes AJ, Arora KK, et al. Autocrine regulation of gonadotropin-releasing hormone secretion in cultured hypothalamic neurons. Endocrinology. 1999; 140 (3): 1423-1431.
29. Winkler N, Bukulmez O, Hardy DB, Carr BR,. Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells. Fertil Steril. 2010; 94 (5): 1832-1839.
30. Minaretzis D, Alper MM, Oskowith SP, Lobel SM, Mortola JF, Pavlou SN,. Gonadotropin-releasing hormone antagonist vs agonist administration in women undergoing controlled ovarian hyperstimulation: cycle performance and in vitro steroidogenesis of granulosa-lutein cells. Am J Obstet Gynecol. 1995; 172 (5): 1518-1525.