The evaluation of clopidogrel use in perioperative general surgery patients: A prospective randomized controlled trial

American Journal of Surgery

Volumn 211, Issue 6, 2016, Pages 1019-1025

  Chu, Edward W ^a   Chernoguz, Artur ^a   Divino, Celia M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Abdominal surgery; Bleeding risk; Clopidogrel; General surgery; Noncardiac surgery; Plavix

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; FRESH FROZEN PLASMA; TICLOPIDINE;

ABDOMINAL HEMATOMA; ABDOMINAL WALL HERNIA; ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLOOD COMPONENT; BLOOD COMPONENT THERAPY; BLOOD TRANSFUSION; CEREBROVASCULAR ACCIDENT; CLINICAL EVALUATION; CONTROLLED STUDY; CORONARY STENT; CORONARY STENTING; DRUG SAFETY; ELECTIVE SURGERY; FEMALE; GENERAL SURGERY; HEART INFARCTION; HEMATOMA; HERNIOPLASTY; HOSPITAL READMISSION; HUMAN; INGUINAL HERNIA; INTRAOPERATIVE PERIOD; LAPAROSCOPIC CHOLECYSTECTOMY; LAPAROSCOPIC INGUINAL HERNIA REPAIR; LAPAROSCOPIC SURGERY; LAPAROSCOPIC VENTRAL HERNIA REPAIR; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; PERCUTANEOUS DRAINAGE; PERIOPERATIVE PERIOD; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; POSTOPERATIVE THROMBOSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SURGICAL PATIENT; SURGICAL RISK; TREATMENT OUTCOME; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; COMPARATIVE STUDY; HOSPITAL MORTALITY; INTRAOPERATIVE COMPLICATIONS; LENGTH OF STAY; MIDDLE AGED; OPERATIVE BLOOD LOSS; PATHOPHYSIOLOGY; PROCEDURES; PROGNOSIS; RISK ASSESSMENT; SURGERY; SURVIVAL RATE;

AGED; BLOOD LOSS, SURGICAL; ELECTIVE SURGICAL PROCEDURES; FEMALE; GENERAL SURGERY; HOSPITAL MORTALITY; HUMANS; INTRAOPERATIVE COMPLICATIONS; LENGTH OF STAY; MALE; MIDDLE AGED; PERIOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; SURGICAL PROCEDURES, OPERATIVE; SURVIVAL RATE; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84961230958     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2015.05.036     Document Type: Article

References (30)

1. M.N. Vicenzi, T. Meislitzer, B. Heitzinger, and et al. Coronary artery stenting and non-cardiac surgery - a prospective outcome study Br J Anaesth 96 2006 686 693
2. P.B. Berger, N.S. Kleiman, M.J. Pencina, et al. EVENT Investigators Frequency of major noncardiac surgery and subsequent adverse events in the year after drug-eluting stent placement: results from the EVENT (Evaluation of Drug-Eluting Stents and Ischemic Events) Registry JACC Cardiovasc Interv 3 2010 920 927
3. A.C. To, G. Armstrong, I. Zeng, and et al. Noncardiac surgery and bleeding after percutaneous coronary intervention Circ Cardiovasc Interv 2 2009 213 221
4. N.L.M. Cruden, S.A. Harding, A.D. Flapan, et al. on behalf of the Scottish Coronary Revascularisation Register Steering Committee Previous coronary stent implantation and cardiac events in patients undergoing noncardiac surgery Circ Cardiovasc Interv 3 2010 236 242
5. S. Anwaruddin, A.T. Askari, H. Saudye, and et al. Characterization of post-operative risk associated with prior drug-eluting stent use JACC Cardiovasc Interv 2 2009 542 549
6. E.S. Brilakis, D.J. Cohen, N.S. Kleiman, and et al. Incidence and clinical outcome of minor surgery in the year after drug-eluting stent implantation: results from the evaluation of drug-eluting stents and ischemic events registry Am Heart J 161 2011 360 366
7. J. Mantz, C.M. Samama, F. Tubach, et al. Stratagem Study Group Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial Br J Anaesth 107 2011 899 910
8. D. Antolovic, A. Rakow, P. Contin, and et al. A randomised controlled pilot trial to evaluate and optimize the use of anti-platelet agents in the perioperative management in patients undergoing general and abdominal surgery - the APAP trial (ISRCTN45810007) Langenbecks Arch Surg 397 2012 297 306
9. A. Oscarsson, A. Gupta, M. Fredrikson, and et al. To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial Br J Anaesth 104 2010 305 312
10. P.J. Devereaux, M. Mrkobrada, D.I. Sessler, et al. POISE-2 Investigators Aspirin in patients undergoing noncardiac surgery N Engl J Med 370 2014 1494 1503
11. M.A. Anderson, T. Ben-Menachem, S.I. Gan, and et al. Management of antithrombotic agents for endoscopic procedures Gastrointest Endosc 70 2009 1060 1070
12. N.A. Kimchi, E. Broide, E. Scapa, and et al. Antiplatelet therapy and the risk of bleeding induced by gastrointestinal endoscopic procedures. A systematic review of the literature and recommendations Digestion 75 2007 36 45
13. D.H. Stone, P.P. Goodney, A. Schanzer, et al. Vascular Study Group of New England Clopidogrel is not associated with major bleeding complications during peripheral arterial surgery J Vasc Surg 54 2011 779 784
14. V.L. Serebruany, A.I. Malinin, J.J. Ferguson, and et al. Bleeding risks of combination vs. single antiplatelet therapy: a meta-analysis of 18 randomized trials comprising 129,314 patients Fundam Clin Pharmacol 22 2008 315 321
15. I. Iakovou, T. Schmidt, E. Bonizzoni, and et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents JAMA 293 2005 2126
16. J.W. van Werkum, A.A. Heestermans, A.C. Zomer, and et al. Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry J Am Coll Cardiol 53 2009 1399
17. I. Ferreira-González, J.R. Marsal, A. Ribera, and et al. Background, incidence, and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation Circulation 122 2010 1017
18. J. Ozao-Choy, Y. Tammaro, M. Fradis, and et al. Clopidogrel and bleeding after general surgery procedures Am Surg 74 2008 721 725
19. A. Chernoguz, D.A. Telem, E. Chu, and et al. Cessation of clopidogrel before major abdominal procedures Arch Surg 146 2011 334 339
20. E.W. Chu, D.A. Telem, A. Chernoguz, and et al. Assessing the risk of clopidogrel-related bleeding complications in patients undergoing inguinal herniorrhaphy Hernia 15 2011 31 35
21. R. Ebrahimi, C. Dyke, R. Mehran, and et al. Outcomes following pre-operative clopidogrel administration in patients with acute coronary syndromes undergoing coronary artery bypass surgery: the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial J Am Coll Cardiol 53 2009 1965 1972
22. H. Grubitzsch, H.G. Wollert, and L. Eckel Emergency coronary artery bypass grafting: does excessive preoperative anticoagulation increase bleeding complications and transfusion requirements? Cardiovasc Surg 9 2001 510 516
23. S. Yende, and R.G. Wunderink Effect of clopidogrel on bleeding after coronary artery bypass surgery Crit Care Med 29 2001 2271 2275
24. T. Fujikawa, A. Tanaka, T. Abe, and et al. Does antiplatelet therapy affect outcomes of patients receiving abdominal laparoscopic surgery? Lessons from more than 1,000 laparoscopic operations in a single tertiary referral hospital J Am Coll Surg 217 2013 1044 1053
25. P.J. Devereaux, L. Goldman, S. Yusuf, and et al. Surveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: a review CMAJ 173 2005 779 788
26. L.A. Fleisher, J.A. Beckman, K.A. Brown, et al. American College of Cardiology American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) American Society of Echocardiography American Society of Nuclear Cardiology Heart Rhythm Society Society of Cardiovascular Anesthesiologists Society for Cardiovascular Angiography and Interventions Society for Vascular Medicine and Biology Society for Vascular Surgery ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery J Am Coll Cardiol 50 2007 e159 241
27. D.T. Mangano Perioperative cardiac morbidity Anesthesiology 72 1990 153 184
28. J.L. Ferreiro, D. Sibbing, and D.J. Angiolillo Platelet function testing and risk of bleeding complications Thromb Haemost 103 2010 1128 1135
29. N.J. Breet, J.W. van Werkum, H.J. Bouman, and et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation JAMA 303 2010 754 762
30. D.A. Gorog, and V. Fuster Platelet function tests in clinical cardiology: unfulfilled expectations J Am Coll Cardiol 61 2013 2115 2129