Long-Term Functional Recovery, Quality of Life, and Pregnancy After Solid Organ Transplantation

Medical Clinics of North America

Volumn 100, Issue 3, 2016, Pages 613-629

  Rao, Swati ^a   Ghanta, Mythili ^a   Moritz, Michael J ^b,c,d   Constantinescu, Serban ^a,d  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEHIGH VALLEY HOSPITAL   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d National Transplantation Pregnancy Registry   (United States)

Author keywords

Functional recovery; Kidney transplantation; Liver transplantation; Pregnancy; Quality of life

Indexed keywords

AZATHIOPRINE; BELATACEPT; CALCINEURIN INHIBITOR; EVEROLIMUS; MYCOPHENOLATE MOFETIL; PREDNISONE; RAPAMYCIN;

BIRTH CONTROL; COMORBIDITY; CONVALESCENCE; FERTILITY; FUNCTIONAL ASSESSMENT; GRAFT FUNCTION; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HIGH RISK PREGNANCY; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LONG TERM FUNCTIONAL RECOVERY; NONHUMAN; ORGAN TRANSPLANTATION; PATIENT COUNSELING; PERIOPERATIVE PERIOD; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PREMATURITY; PRIORITY JOURNAL; QUALITY OF LIFE; REPRODUCTIVE HEALTH; REVIEW; SOLID ORGAN TRANSPLANTATION; TREATMENT RESPONSE; FEMALE; FOLLOW UP; NEWBORN; POSTOPERATIVE COMPLICATIONS; PREGNANCY COMPLICATIONS;

FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT, NEWBORN; LIVER TRANSPLANTATION; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREGNANCY, HIGH-RISK; QUALITY OF LIFE;

EID: 84961221224     PISSN: 00257125     EISSN: 15579859     Source Type: Journal    
DOI: 10.1016/j.mcna.2016.01.010     Document Type: Review

References (76)

1. Matas A.J., Smith J.M., Skeans M.A., et al. OPTN/SRTR 2013 annual data report: kidney. Am J Transplant 2015, 15(Suppl 2):1-34.
2. Kim W.R., Lake J.R., Smith J.M., et al. OPTN/SRTR 2013 annual data report: liver. Am J Transplant 2015, 15(Suppl 2):1-28.
3. Murray J.E., Reid D.E., Harrison J.H., et al. Successful pregnancies after human renal transplantation. N Engl J Med 1963, 269:341-343.
4. Walcott W.O., Derick D.E., Jolley J.J., et al. Successful pregnancy in a liver transplant patient. Am J Obstet Gynecol 1978, 132(3):340-341.
5. Deshpande N.A., James N.T., Kucirka L.M., et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant 2011, 11(11):2388-2404.
6. Deshpande N.A., James N.T., Kucirka L.M., et al. Pregnancy outcomes of liver transplant recipients: a systematic review and meta-analysis. Liver Transpl 2012, 18(6):621-629.
7. Campagna F., Montagnese S., Schiff S., et al. Cognitive impairment and electroencephalographic alterations before and after liver transplantation: what is reversible?. Liver Transpl 2014, 20(8):977-986.
8. Griva K., Thompson D., Jayasena D., et al. Cognitive functioning pre- to post-kidney transplantation: a prospective study. Nephrol Dial Transplant 2006, 21(11):3275-3282.
9. Pinson C.W., Feurer I.D., Payne J.L., et al. Health-related quality of life after different types of solid organ transplantation. Ann Surg 2000, 232(4):597-607.
10. Mosconi G., Cuna V., Tonioli M., et al. Physical activity in solid organ transplant recipients: preliminary results of the Italian project. Kidney Blood Press Res 2014, 39(2-3):220-227.
11. Patcai J.T., Disotto-Monastero M.P., Gomez M., et al. Inpatient rehabilitation outcomes in solid organ transplantation: results of a unique partnership between the rehabilitation hospital and the multi-organ transplant unit in an acute hospital. Open J Ther Rehabil 2013, 1(2):52-61.
12. Tzvetanov I., D'Amico G., Walczak D., et al. High rate of unemployment after kidney transplantation: analysis of the United Network for Organ Sharing database. Transplant Proc 2014, 46(5):1290-1294.
13. Saab S., Wiese C., Ibrahim A.B., et al. Employment and quality of life in liver transplant recipients. Liver Transpl 2007, 13(9):1330-1338.
14. Weng L.C., Chen H.C., Huang H.L., et al. Change in the type of work of postoperative liver transplant patients. Transplant Proc 2012, 44(2):544-547.
15. Joseph J.T., Baines L.S., Morris M.C., et al. Quality of life after kidney and pancreas transplantation: a review. Am J Kidney Dis 2003, 42(3):431-445.
16. Matas A.J., Halbert R.J., Barr M.L., et al. Life satisfaction and adverse effects in renal transplant recipients: a longitudinal analysis. Clin Transplant 2002, 16(2):113-121.
17. Muehrer R.J., Becker B.N. Life after transplantation: new transitions in quality of life and psychological distress. Semin Dial 2005, 18(2):124-131.
18. Yang L.S., Shan L.L., Saxena A., et al. Liver transplantation: a systematic review of long-term quality of life. Liver Int 2014, 34(9):1298-1313.
19. Valderrabano F., Jofre R., Lopez-Gomez J.M. Quality of life in end-stage renal disease patients. Am J Kidney Dis 2001, 38(3):443-464.
20. Hathaway D., Winsett R., Prendergast M., et al. The first report from the Patient Outcomes Registry for Transplant Effects on Life (PORTEL): differences in side-effects and quality of life by organ type, time since transplant and immunosuppressive regimens. Clin Transplant 2003, 17(3):183-194.
21. Kugler C., Gottlieb J., Warnecke G., et al. Health-related quality of life after solid organ transplantation: a prospective, multiorgan cohort study. Transplantation 2013, 96(3):316-323.
22. Cukor D., Rosenthal D.S., Jindal R.M., et al. Depression is an important contributor to low medication adherence in hemodialyzed patients and transplant recipients. Kidney Int 2009, 75(11):1223-1229.
23. Johnson C.D., Wicks M.N., Milstead J., et al. Racial and gender differences in quality of life following kidney transplantation. Image J Nurs Sch 1998, 30(2):125-130.
24. Yildirim A. The importance of patient satisfaction and health-related quality of life after renal transplantation. Transplant Proc 2006, 38(9):2831-2834.
25. Cetingok M., Hathaway D., Winsett R. Contribution of post-transplant social support to the quality of life of transplant recipients. Soc Work Health Care 2007, 45(3):39-56.
26. Dew M.A., Switzer G.E., Goycoolea J.M., et al. Does transplantation produce quality of life benefits? A quantitative analysis of the literature. Transplantation 1997, 64(9):1261-1273.
27. Overbeck I., Bartels M., Decker O., et al. Changes in quality of life after renal transplantation. Transplant Proc 2005, 37(3):1618-1621.
28. Czyzewski L., Sanko-Resmer J., Wyzgal J., et al. Assessment of health-related quality of life of patients after kidney transplantation in comparison with hemodialysis and peritoneal dialysis. Am J Transplant 2014, 19:576-585.
29. Griva K., Davenport A., Newman S.P. Health-related quality of life and long-term survival and graft failure in kidney transplantation: a 12-year follow-up study. Transplantation 2013, 95(5):740-749.
30. Rogal S.S., Dew M.A., Fontes P., et al. Early treatment of depressive symptoms and long-term survival after liver transplantation. Am J Transplant 2013, 13(4):928-935.
31. Wyld M.L., Clayton P.A., Jesudason S., et al. Pregnancy outcomes for kidney transplant recipients. Am J Transplant 2013, 13(12):3173-3182.
32. Holley J.L., Schmidt R.J., Bender F.H., et al. Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis 1997, 29(5):685-690.
33. Cundy T.F., O'Grady J.G., Williams R. Recovery of menstruation and pregnancy after liver transplantation. Gut 1990, 31(3):337-338.
34. French V.A., Davis J.S., Sayles H.S., et al. Contraception and fertility awareness among women with solid organ transplants. Obstet Gynecol 2013, 122(4):809-814.
35. Krajewski C.M., Geetha D., Gomez-Lobo V. Contraceptive options for women with a history of solid-organ transplantation. Transplantation 2013, 95(10):1183-1186.
36. Constantinescu S., Gomez-Lobo V., Davison J.M., et al. Pregnancy and contraception in transplantation. Textbook of organ transplantation 2014, vol. 97:1161-1178. Wiley-Blackwell, London.
37. McKay D.B., Josephson M.A., Armenti V.T., et al. Reproduction and transplantation: report on the AST consensus conference on reproductive issues and transplantation. Am J Transplant 2005, 5(7):1592-1599.
38. Coscia L.A., Constantinescu S., Moritz M.J., et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transplant 2009, 103-122.
39. Fraser F.C., Sajoo A. Teratogenic potential of corticosteroids in humans. Teratology 1995, 51(1):45-46.
40. Park-Wyllie L., Mazzotta P., Pastuszak A., et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000, 62(6):385-392.
41. Hviid A., Molgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ 2011, 183(7):796-804.
42. Sifontis N.M., Coscia L.A., Constantinescu S., et al. Pregnancy outcomes in solid organ transplant recipients with exposure to mycophenolate mofetil or sirolimus. Transplantation 2006, 82(12):1698-1702.
43. Constantinescu S., Axelrod P., Coscia L.A., et al. Pregnancy outcomes in kidney recipients who discontinued mycophenolic acid products prior to conception. J Am Soc Nephrol 2013, 24:861A. [abstract].
44. Coscia L.A., Armenti D.P., King R.W., et al. Update on the teratogenicity of mycophenolate mofetil. J Pediatr Genet 2015, 4(2):42-45.
45. Cleary B.J., Kallen B. Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A Clin Mol Teratol 2009, 85(7):647-654.
46. Armenti V.T., Ahlswede K.M., Ahlswede B.A., et al. National Transplantation Pregnancy Registry: outcomes of 154 pregnancies in cyclosporine-treated female kidney transplant recipients. Transplantation 1994, 57(4):502-506.
47. Bar Oz B., Hackman R., Einarson T., et al. Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis. Transplantation 2001, 71(8):1051-1055.
48. Kainz A., Harabacz I., Cowlrick I.S., et al. Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. Transplantation 2000, 70(12):1718-1721.
49. Framarino dei Malatesta M., Corona L.E., De Luca L., et al. Successful pregnancy in a living-related kidney transplant recipient who received sirolimus throughout the whole gestation. Transplantation 2011, 91(9):e69-e71.
50. Jankowska I., Oldakowska-Jedynak U., Jabiry-Zieniewicz Z., et al. Absence of teratogenicity of sirolimus used during early pregnancy in a liver transplant recipient. Transplant Proc 2004, 36(10):3232-3233.
51. Zuber J., Anglicheau D., Elie C., et al. Sirolimus may reduce fertility in male renal transplant recipients. Am J Transplant 2008, 8(7):1471-1479.
52. Veroux M., Corona D., Veroux P. Pregnancy under everolimus-based immunosuppression. Transpl Int 2011, 24(12):e115-e117.
53. Centers for Disease Control and Prevention (CDC) Update on overall prevalence of major birth defects-Atlanta, Georgia, 1978-2005. MMWR Morb Mortal Wkly Rep 2008, 57(1):1-5.
54. Coscia L.A., Constantinescu S., Davison J.M., et al. Immunosuppressive drugs and fetal outcome. Best Pract Res Clin Obstet Gynaecol 2014, 28(8):1174-1187.
55. National Transplantation Pregnancy Registry (NTPR) 2014 annual report 2015, Gift of Life Institute, Philadelphia.
56. Martin J.A., Hamilton B.E., Ventura S.J., et al. Births: final data for 2010. Natl Vital Stat Rep 2012, 61(1):1-72.
57. Davison J.M. Pregnancy in renal allograft recipients: problems, prognosis and practicalities. Baillieres Clin Obstet Gynaecol 1994, 8(2):501-525.
58. Correa A., Gilboa S.M., Besser L.M., et al. Diabetes mellitus and birth defects. Am J Obstet Gynecol 2008, 199(3):237.e1-237.e9.
59. McKay D.B., Josephson M.A. Pregnancy after kidney transplantation. Clin J Am Soc Nephrol 2008, 3(Suppl 2):S117-S125.
60. Constantinescu S., Axelrod P., Coscia L.A., et al. Pregnancy outcomes in kidney recipients after retransplantation. Am J Transplant 2012, 12(Suppl 3):155. [abstract]. A430.
61. Constantinescu S., Coscia L., Armenti D., et al. Pregnancy outcomes in female kidney transplant recipients: does ethnicity have an influence?. Am J Transplant 2015, 15(Suppl 3). [abstract].
62. First M.R., Combs C.A., Weiskittel P., et al. Lack of effect of pregnancy on renal allograft survival or function. Transplantation 1995, 59(4):472-476.
63. Sturgiss S.N., Davison J.M. Effect of pregnancy on the long-term function of renal allografts: an update. Am J Kidney Dis 1995, 26(1):54-56.
64. Armenti V.T., Ahlswede K.M., Ahlswede B.A., et al. Variables affecting birthweight and graft survival in 197 pregnancies in cyclosporine-treated female kidney transplant recipients. Transplantation 1995, 59(4):476-479.
65. Blume C., Pischke S., von Versen-Hoynck F., et al. Pregnancies in liver and kidney transplant recipients: a review of the current literature and recommendation. Best Pract Res Clin Obstet Gynaecol 2014, 28(8):1123-1136.
66. Coscia L.A., Davison J.M., Moritz M.J., et al. Pregnancy after liver transplantation. Contemporary liver transplantation 2015, 1-20. Springer International, Switzerland. C. Doria (Ed.).
67. Nagy S., Bush M.C., Berkowitz R., et al. Pregnancy outcome in liver transplant recipients. Obstet Gynecol 2003, 102(1):121-128.
68. Armenti V.T., Herrine S.K., Radomski J.S., et al. Pregnancy after liver transplantation. Liver Transpl 2000, 6(6):671-685.
69. Kubo S., Uemoto S., Furukawa H., et al. Pregnancy outcomes after living donor liver transplantation: results from a Japanese survey. Liver Transpl 2014, 20(5):576-583.
70. Constantinescu S., Pai A., Coscia L.A., et al. Breast-feeding after transplantation. Best Pract Res Clin Obstet Gynaecol 2014, 28(8):1163-1173.
71. Holdsworth S., Atkins R.C., de Kretser D.M. The pituitary-testicular axis in men with chronic renal failure. N Engl J Med 1977, 296(22):1245-1249.
72. Handelsman D.J., McDowell I.F., Caterson I.D., et al. Testicular function after renal transplantation: comparison of cyclosporin A with azathioprine and prednisone combination regimes. Clin Nephrol 1984, 22(3):144-148.
73. Madersbacher S., Ludvik G., Stulnig T., et al. The impact of liver transplantation on endocrine status in men. Clin Endocrinol (Oxf) 1996, 44(4):461-466.
74. Jones A., Clary M.J., McDermott E., et al. Outcomes of pregnancies fathered by solid-organ transplant recipients exposed to mycophenolic acid products. Prog Transplant 2013, 23(2):153-157.
75. Schreiber-Zamora J., Kociszewska-Najman B., Borek-Dzieciol B., et al. Neurological development of children born to liver transplant recipients. Transplant Proc 2014, 46(8):2798-2801.
76. Nulman I., Sgro M., Barrera M., et al. Long-term neurodevelopment of children exposed in utero to cyclosporine after maternal renal transplant. Paediatr Drugs 2010, 12(2):113-122.