Greater loss of object than spatial mnemonic discrimination in aged adults

Hippocampus

Volumn 26, Issue 4, 2016, Pages 417-422

  Reagh, Zachariah M ^a   Ho, Huy D ^a   Leal, Stephanie L ^a,b   Noche, Jessica A ^a   Chun, Amanda ^a   Murray, Elizabeth A ^a   Yassa, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Aging; Discrimination; Memory; Pattern separation; Spatial

Indexed keywords

ADULT; AGE; AGED; AGING; ARTICLE; COGNITION; ENTORHINAL CORTEX; HUMAN; HUMAN EXPERIMENT; PERIRHINAL CORTEX; PRIORITY JOURNAL; SIGNAL DETECTION; SPATIAL DISCRIMINATION; SPATIAL MEMORY; WORD MEMORY TEST; ADOLESCENT; LINGUISTICS; MEMORY DISORDER; MENTAL HEALTH; MIDDLE AGED; PERCEPTIVE DISCRIMINATION; PSYCHOLOGIC TEST; PSYCHOLOGY; SPEECH PERCEPTION; VERY ELDERLY; VISION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; DISCRIMINATION (PSYCHOLOGY); HUMANS; MEMORY DISORDERS; MENTAL STATUS SCHEDULE; MIDDLE AGED; PSYCHOLINGUISTICS; PSYCHOLOGICAL TESTS; SPATIAL MEMORY; SPEECH PERCEPTION; VISUAL PERCEPTION; YOUNG ADULT;

EID: 84961217517     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.22562     Document Type: Article

References (30)

1. Braak H, Braak E, Bohl J. 1993. Staging of Alzheimer-related cortical destruction. Eur Neurol 9:257-261. discussion 269-272
2. Braak H, Braak E. 1995. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-278.
3. Braak H, Braak E. 1996. Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165:3-12.
4. Burke SN, Wallace JL, Hartzell AL, Nematollahi S, Plange K, Barnes CA. 2011. Age-associated deficits in pattern separation functions of the perirhinal cortex: A cross-species consensus. Behav Neurosci 125:836-847.
5. Burke SN, Maurer AP, Nematollahi S, Uprety A, Wallace JL, Barnes CA. 2014. Advanced age dissociates dual functions of the perirhinal cortex. J Neurosci 34:467-480.
6. Craik FIM, Tulving E. 1975. Depth of processing and the retention of words in episodic memory. J Exp Psychol Gen 104:268-294.
7. Eichenbaum H, Yonelinas AP, Ranganath C. 2007. The medial temporal lobe and recognition memory. Annu Rev Neurosci 30:123-152.
8. Gallahger M, Bizon JL, Hoyt EC, Helm KA, Lund PK. 2003. Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment. Exp Geront 38:71-77.
9. Holden HM, Hoebel C, Loftis K, Gilbert PE. 2012. Spatial pattern separation in cognitively normal young and older adults. Hippocampus 22:1826-1832.
10. Hunsaker MR, Chen V, Tran GT, Kesner RP. 2013. The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory: A test of the binding of items and context model. Hippocampus 23:380-391.
11. Jack CR, Petersen RC, Xu YC, Waring SC, O'Brien PC, Tangalos EG, Smith GE, Ivnik RJ, Kokmen E. 1997. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology 49:786-794.
12. Jagust W. 2013. Vulnerable neural systems and the borderland of brain aging and neurodegeneration. Neuron 77:219-234.
13. Khan U, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA. 2014. Isolating the anatomical site and molecular drivers of entorhinal dysfunction in preclinical Alzheimer's disease and mapping a pattern of cortical spread. Nat Neurosci 17:304-311.
14. Lacy JW, Yassa MA, Stark SM, Muftuler LT, Stark CEL. 2011. Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn Mem 18:15-18.
15. Mickes L, Wixted JT, Wais PE. 2007. A direct test of the unequal-variance signal detection model of recognition memory. Psychon Bull Rev 14:858-865.
16. Norman G, Eacott MJ. 2005. Dissociable effects of lesions to the perirhinal cortex and postrhinal cortex on memory for context and objects in rats. Behav Neurosci 119:557-566.
17. Pierce JW. 2007. PsychoPy - Psychophysics software in Python. J Neurosci Methods 162:8-13.
18. Pierce JW. 2009. Generating stimuli for neuroscience using PsychoPy. Front Neuroinform 2:10.
19. Ranganath C, Ritchey M. 2012. Two cortical systems for memory-guided behavior. Nat Reviews Neurosci 13:713-726.
20. Raz N, Rodrigue KM, Head D, Kennedy KM, Acker JD. 2004. Differential aging of the medial temporal lobe. Neurology 62:433-438.
21. Reagh ZM, Roberts JM, Ly M, DiProspero N, Murray E, Yassa MA. 2013. Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment. Hippocampus 24:303-314.
22. Reagh ZM, Yassa MA. 2014. Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans. Proc Natl Acad Sci USA 111:E4264-E4273.
23. Ryan L, Cardoza JA, Barense MD, Kawa KH, Wallentin-Flores J, Arnold WT, Alexander GE. 2012. Age-related impairment in a complex object discrimination task that engages perirhinal cortex. Hippocampus 22:1978-1989.
24. Stark SM, Yassa MA, Stark CEL. 2010. Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learn Mem 17:284-288.
25. Stranahan AM, Mattson MP. 2010. Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's Disease. Neural Plast 2010:108190-
26. Stranahan AM, Haberman RP, Gallagher M. 2011. Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats. Cereb Cortex 21:392-400.
27. Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Siedel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB, den Dunnen W, Rüb U. Precortical phase of Alzheimer's disease (AD)-related tau cytoskeletal pathology. Brain Pathology ISSN 1015-6305 (in press).
28. Theofilas P, Dunlop S, Heinsen H, Grinberg LT. 2015. Turning on the light within: Subcortical nuclei of the isodendritic core and their role in Alzheimer's disease pathogenesis. J Alz Disease 46:17-34.
29. Yassa MA. 2014. Ground zero in Alzheimer's disease. Nat Neurosci 17:146-147.
30. Yassa MA, Lacy JW, Stark SM, Albert MS, Gallagher M, Stark CEL. 2010. Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21:968-979.