Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation

Scandinavian Journal of Rheumatology

Volumn 45, Issue 5, 2016, Pages 379-383

  Matzelle, M ^a   Shaw, A ^a   Baum, R ^a   Maeda, Y ^a   Li, J ^a   Karmakar, S ^a   Manning, C ^a   Walsh, N ^b   Rosen, V ^c   Gravallese, Ellen M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; OSTEOGENIN; TUMOR NECROSIS FACTOR; BMP3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN INDUCED ARTHRITIS; ARTHRITIS; ARTICLE; BONE EROSION; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA ISOLATION; SERUM TRANSFER ARTHRITIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; GENETICS; METABOLISM; SKULL;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 3; IN VITRO TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; OSTEOBLASTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKULL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84961216539     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.3109/03009742.2015.1126347     Document Type: Article

References (15)

1. E.M.Gravallese, S.R.Goldring Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis. Arthritis Rheum 2000;43:2143–51.
2. M.S.Nanes. Tumor necrosis factor-alpha:molecular and cellular mechanisms in skeletal pathology. Gene 2003;321:1–15.
3. P.Stashenko, F.E.Dewhirst, M.L.Rooney, L.A.Desjardins, J.D.Heeley. Interleukin-1 beta is a potent inhibitor of bone formation in vitro. J Bone Miner Res 1987;2:559–65.
4. M.M.Matzelle, M.A.Gallant, K.W.Condon, N.C.Walsh, C.A.Manning, G.S.Stein, et al. Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway. Arthritis Rheum 2011;64:1540–50.
5. S.Kokabu, L.Gamer, K.Cox, J.Lowery, K.Tsuji, R.Raz, et al. BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b. Mol Endocrinol 2012;26:87–94.
6. A.Daluiski, T.Engstrand, M.E.Bahamonde, L.W.Gamer, E.Agius, S.L.Stevenson, et al. Bone morphogenetic protein-3 is a negative regulator of bone density. Nat Genet 2001;27:84–8.
7. L.W.Gamer, K.Cox, J.M.Carlo, V.Rosen. Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures. Dev Dyn 2009;238:2374–81.
8. T.Nakase, K.Takaoka, K.Masuhara, K.Shimizu, H.Yoshikawa, T.Ochi. Interleukin-1 beta enhances and tumor necrosis factor-alpha inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteoblastic cells. Bone 1997;21:17–21.
9. S.Yao, V.Prpic, F.Pan, G.E.Wise. TNF-alpha upregulates expression of BMP-2 and BMP-3 genes in the rat dental follicle–implications for tooth eruption. Connect Tissue Res 2010;51:59–66.
10. A.S.Korganow, H.Ji, S.Mangialaio, V.Duchatelle, R.Pelanda, T.Martin, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451–61.
11. A.R.Pettit, H.Ji, D.von Stechow, R.Muller, S.R.Goldring, Y.Choi, et al. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 2001;159:1689–99.
12. N.C.Walsh, S.Reinwald, C.A.Manning, K.W.Condon, K.Iwata, D.B.Burr, et al. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res 2009;24:1572–85.
13. P.L.van Lent, L.Grevers, E.Lubberts, T.J.de Vries, K.C.Nabbe, S.Verbeek, et al. Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis:uncoupling of cartilage damage from bone erosion and joint inflammation. Arthritis Rheum 2006;54:3868–77.
14. K.J.Livak, T.D.Schmittgen. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402–8.
15. B.Gortz, S.Hayer, K.Redlich, J.Zwerina, M.Tohidast-Akrad, B.Tuerk, et al. Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation. J Bone Miner Res 2004;19:990–8.