A design of experiment study of nanoprecipitation and nano spray drying as processes to prepare plga nano-and microparticles with defined sizes and size distributions

Pharmaceutical Research

Volumn 32, Issue 8, 2015, Pages 2609-2624

  Draheim, Christina ^a   De Crécy, Francois ^c   Hansen, Steffi ^a   Collnot, Eva Maria ^a   Lehr, Claus Michael ^a,b  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c CEA GRENOBLE   (France)

Author keywords

B chiNano spraydryer; Nanoparticles; Nanoprecipitation; Quality by design; Submicron particles

Indexed keywords

NANOPARTICLE; POLOXAMER; POLYGLACTIN; POLYSORBATE 80; SORBITAN STEARATE; EXCIPIENT; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FACTORIAL DESIGN; NANOFABRICATION; NANOPRECIPITATION; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; ALGORITHM; CHEMISTRY; DESICCATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; MEDICINAL CHEMISTRY; PROCEDURES; REPRODUCIBILITY; SOFTWARE;

ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DRUG DELIVERY SYSTEMS; DRUG DESIGN; EXCIPIENTS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; REPRODUCIBILITY OF RESULTS; SOFTWARE;

EID: 84961206178     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1647-9     Document Type: Article

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