Enhancement of triptolide-loaded micelles on tumorigenicity inhibition of human ovarian cancer

Journal of Biomaterials Science, Polymer Edition

Volumn 27, Issue 7, 2016, Pages 545-556

  Wang, You ^a,b   Liu, Ting ^a,b   Li, He ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Key Laboratory of Gynecologic Oncology   (China)

Author keywords

apoptosis; invasion; migration; proliferation; Triptolide (TP); Triptolideloaded micelles (TP micelles)

Indexed keywords

CELL DEATH; CELL PROLIFERATION; CELLS; CHEMOTHERAPY; CYTOLOGY; DISEASES; DRUG PRODUCTS; TOXICITY;

ANTI-TUMOR ACTIVITIES; DOSE-DEPENDENT MANNER; DRUG DELIVERY SYSTEM; INVASION; MIGRATION; PROLIFERATION; THERAPEUTIC EFFICACY; TRIPTOLIDE;

MICELLES;

CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRIPTOLIDE; ANTINEOPLASTIC AGENT; DITERPENE; DRUG CARRIER; EPOXIDE; MICELLE; PHENANTHRENE DERIVATIVE;

APOPTOSIS; ARTICLE; BIOASSAY; CARCINOGENICITY; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; ENZYME INHIBITION; FILTERS AND MEMBRANES; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICELLE; OVARIAN CANCER CELL LINE; OVARY CANCER; PRIORITY JOURNAL; TRANSWELL ASSAY; TUMOR CELL LINE; WOUND HEALING; CARCINOGENESIS; CELL MOTION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FEMALE; METABOLISM; OVARY TUMOR; PATHOLOGY; S PHASE CELL CYCLE CHECKPOINT; TIME FACTOR; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOGENESIS; CASPASES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; EPOXY COMPOUNDS; FEMALE; HUMANS; MICELLES; NEOPLASM INVASIVENESS; NF-KAPPA B; OVARIAN NEOPLASMS; PHENANTHRENES; S PHASE CELL CYCLE CHECKPOINTS; TIME FACTORS;

EID: 84961205000     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2015.1131667     Document Type: Article

References (18)

1. Jemal A, Murray T, Samuels A, et al. Cancer statistics, 2003. CA Cancer J. Clin. 2003; 53: 5-26. 10.3322/canjclin.53.1.5
2. Campos SM, Ghosh S. A current review of targeted therapeutics for ovarian cancer. J. Oncol. 2010; 2010; Article ID. 149362, pp. 11
3. Baek SJ, Park JY, Kim DY, et al. Stage IIIC epithelial ovarian cancer classified solely by lymph node metastasis has a more favorable prognosis than other types of stage IIIC epithelial ovarian cancer. J. Gynecol. Oncol. 2008; 19: 223-228. 10.3802/jgo.2008.19.4.223
4. Xiong FL, Chen HB, Chang XL, et al. Research progress of triptolide-loaded nanoparticles delivery systems. Pro. Ann. Int. Conf. IEEE Engn. Med. & Biol. Soc. 2005; 5: 4966-4969
5. Rosenholm JM, Sahlgren C, Lindén M. Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-opportunities & challenges. Nanoscale. 2010; 2: 1870-1883. 10.1039/c0nr00156b
6. He MF, Huang YH, Wu LW, et al. Triptolide functions as a potent angiogenesis inhibitor. Int. J. Cancer. 2010; 126: 266-278. 10.1002/ijc.v126:1
7. Liu Q. Triptolide and its expanding multiple pharmacological functions. Int. Immunopharmacol. 2011; 11: 377-383. 10.1016/j.intimp.2011.01.012
8. Tao Y, Zhang ML, Ma PC, et al. Triptolide inhibits proliferation and induces apoptosis of human melanoma A375 cells. Asian Pac. J. Cancer Prev. 2012; 13: 1611-1615. 10.7314/APJCP.2012.13.4.1611
9. Zheng Q, Gong T, Sun X, et al. Synthesis, characterization and in vitro evaluation of triptolide-lysozyme conjugate for renal targeting delivery of triptolide. Arch. Pharmacal Res. 2006; 29: 1164-1170. 10.1007/BF02969309
10. Li H, Wen XS, Di W. In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles. Arzneim.-Forsch. 2012; 62: 340-344
11. Bratton SB, MacFarlane M, Cain K, et al. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp. Cell Res. 2000; 256: 27-33. 10.1006/excr.2000.4835
12. Brauns SC, Dealtry G, Milne P, et al. Caspase-3 activation and induction of PARP cleavage by cyclic dipeptide cyclo(Phe-Pro) in HT-29 cells. Anticancer. Res. 2005; 25: 4197-4202
13. DAmours D, Sallmann FR, Dixit VM, et al. Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J. Cell Sci. 2001; 114: 3771-3778
14. Shishodia S, Amin HM, Lai R, et al. Curcumin (diferuloylmethane) inhibits constitutive NF-B activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem. Pharmacol. 2005; 70: 700-713. 10.1016/j.bcp.2005.04.043
15. Varfolomeev E, Blankenship JW, Wayson SM, et al. IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-B Activation, and TNFα-Dependent Apoptosis. Cell. 2007; 131: 669-681. 10.1016/j.cell.2007.10.030
16. Huang S, Robinson JB, Deguzman A, et al. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer. Res. 2000; 60: 5334-5339
17. Kaverina I, Straube A. Regulation of cell migration by dynamic microtubules. Semin. Cell Dev. Biol. 2011; 22: 968-974. 10.1016/j.semcdb.2011.09.017
18. Jordan MA, Horwitz SB, Lobert S, et al. Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine. Semin. Oncol. 2008; 35: S6-S12. 10.1053/j.seminoncol.2008.01.009