메뉴 건너뛰기




Volumn 36, Issue 6, 2016, Pages 433-441

Tumour Risk with Once-Weekly Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes Mellitus Patients: A Systematic Review

Author keywords

[No Author keywords available]

Indexed keywords

ALBIGLUTIDE; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE RECEPTOR AGONIST; INSULIN; LIRAGLUTIDE; PLACEBO;

EID: 84961174431     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.1007/s40261-016-0389-8     Document Type: Review
Times cited : (19)

References (51)
  • 1
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • COI: 1:CAS:528:DC%2BD2sXmsVynsrY%3D, PID: 17498508
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131–57.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 2
    • 15444367142 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BD2MXhtFGmurs%3D, PID: 15700891
    • Kolterman OG, Kim DD, Shen L, et al. Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus. Am J Health Syst Pharm. 2005;62:173–81.
    • (2005) Am J Health Syst Pharm , vol.62 , pp. 173-181
    • Kolterman, O.G.1    Kim, D.D.2    Shen, L.3
  • 3
    • 0347360186 scopus 로고    scopus 로고
    • Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD3sXhtVWisrzJ, PID: 14700743
    • Nielsen LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul Pept. 2004;117:77–88.
    • (2004) Regul Pept , vol.117 , pp. 77-88
    • Nielsen, L.L.1    Young, A.A.2    Parkes, D.G.3
  • 4
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • COI: 1:CAS:528:DC%2BD2sXhtlaqu7jI, PID: 17928588
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007;87:1409–39.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 5
    • 41549105255 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, glucose homeostasis and diabetes
    • COI: 1:CAS:528:DC%2BD1cXktlCktLs%3D, PID: 18353723
    • Holst JJ, Deacon CF, Vilsboll T, et al. Glucagon-like peptide-1, glucose homeostasis and diabetes. Trends Mol Med. 2008;14:161–8.
    • (2008) Trends Mol Med , vol.14 , pp. 161-168
    • Holst, J.J.1    Deacon, C.F.2    Vilsboll, T.3
  • 6
    • 75549091061 scopus 로고    scopus 로고
    • Incretin-based therapies: viewpoints on the way to consensus
    • COI: 1:CAS:528:DC%2BC3cXpvFOgsQ%3D%3D, PID: 19875556
    • Nauck MA, Vilsboll T, Gallwitz B, et al. Incretin-based therapies: viewpoints on the way to consensus. Diabetes Care. 2009;32(Suppl 2):S223–31.
    • (2009) Diabetes Care , vol.32 , pp. S223-S231
    • Nauck, M.A.1    Vilsboll, T.2    Gallwitz, B.3
  • 7
    • 53249142132 scopus 로고    scopus 로고
    • Duration-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, openlabel, non-inferiority study
    • COI: 1:CAS:528:DC%2BD1cXhtF2ku7nN, PID: 18782641
    • Drucker DJ, Buse JB, Taylor Kendall DM, et al. Duration-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, openlabel, non-inferiority study. Lancet. 2008;372(9645):1240–50. doi:10.1016/S0140-6736(08)61206-4.
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor Kendall, D.M.3
  • 8
    • 67649666737 scopus 로고    scopus 로고
    • LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomized, parallel-group, multinational, open-label trial (LEAD-6)
    • COI: 1:CAS:528:DC%2BD1MXotFCgtb4%3D, PID: 19515413
    • Buse JB, Rosenstock J, Sesti G, et al. LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomized, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374(9683):39–47. doi:10.1016/S0140-6736(09)60659-0.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 9
    • 84928183099 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor agonist therapy is more efficacious than insulin glargine for poorly controlled type 2 diabetes: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXntFGlsrY%3D, PID: 25047138
    • Liu FP, Dong JJ, Yang Q, et al. Glucagon-like peptide 1 receptor agonist therapy is more efficacious than insulin glargine for poorly controlled type 2 diabetes: a systematic review and meta-analysis. J Diabetes. 2015;7:322–8.
    • (2015) J Diabetes , vol.7 , pp. 322-328
    • Liu, F.P.1    Dong, J.J.2    Yang, Q.3
  • 10
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • COI: 1:CAS:528:DyaK2sXnsFams70%3D, PID: 9374685
    • Nauck MA, Niedereichholz U, Ettler R, et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol. 1997;273(5 Pt 1):E981–8.
    • (1997) Am J Physiol , vol.273 , Issue.5 , pp. E981-E988
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 11
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • COI: 1:STN:280:DyaK2c%2FgvF2qtQ%3D%3D, PID: 8405741
    • Nauck MA, Kleine N, Orskov C, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36:741–4.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3
  • 12
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, an insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • COI: 1:CAS:528:DC%2BD38XitlWnsro%3D, PID: 11889194
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, an insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab. 2002;87:1239–46.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 13
    • 84938933059 scopus 로고    scopus 로고
    • Accessed 23 Apr 2015
    • Bydureon package insert. http://www.azpicentral.com/bydureon/pi_bydureon.pdf#page=1. Accessed 23 Apr 2015.
    • Bydureon package insert
  • 14
    • 84938912049 scopus 로고    scopus 로고
    • Accessed 3 May 2015
    • Tanzeum package insert. https://gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Tanzeum/pdf/TANZEUM-PI-MG-IFU-COMBINED.PDF. Accessed 3 May 2015.
    • Tanzeum package insert
  • 15
    • 84938944670 scopus 로고    scopus 로고
    • Accessed 3 May 2015
    • Trulicity package insert. http://pi.lilly.com/us/trulicity-uspi.pdf. Accessed 3 May 2015.
    • Trulicity package insert
  • 16
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • PID: 12111919
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 17
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis
    • COI: 1:STN:280:DC%2BD3cvotVylsA%3D%3D, PID: 10877304
    • Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455–63.
    • (2000) Biometrics , vol.56 , pp. 455-463
    • Duval, S.1    Tweedie, R.2
  • 18
    • 84975593095 scopus 로고    scopus 로고
    • Safety and efficacy study of albiglutide in type 2 diabetes
    • Accessed 25 Oct 2015
    • GlaxoSmithKline. Safety and efficacy study of albiglutide in type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT00849017?term=NCT00849017&rank=1. Accessed 25 Oct 2015.
    • GlaxoSmithKline
  • 19
    • 84975593098 scopus 로고    scopus 로고
    • A study of the efficacy and safety of albiglutide in subjects with type 2 diabetes with renal impairment
    • Accessed 25 Oct 2015
    • GlaxoSmithKline. A study of the efficacy and safety of albiglutide in subjects with type 2 diabetes with renal impairment. https://clinicaltrials.gov/ct2/show/NCT01098539?term=01098539&rank=1. Accessed 25 Oct 2015.
    • GlaxoSmithKline
  • 20
    • 84975593048 scopus 로고    scopus 로고
    • A monotherapy study to evaluate the efficacy and safety of 2 dose levels of albiglutide in Japanese subjects with type 2 diabetes mellitus
    • Accessed 25 Oct 2015
    • GlaxoSmithKline. A monotherapy study to evaluate the efficacy and safety of 2 dose levels of albiglutide in Japanese subjects with type 2 diabetes mellitus. https://clinicaltrials.gov/ct2/show/NCT01733758?term=01733758&rank=1. Accessed 25 Oct 2015.
    • GlaxoSmithKline
  • 21
    • 84975593056 scopus 로고    scopus 로고
    • A study to determine the efficacy and safety of albiglutide as compared with liraglutide
    • Accessed 25 Oct 2015
    • GlaxoSmithKline. A study to determine the efficacy and safety of albiglutide as compared with liraglutide. https://clinicaltrials.gov/ct2/show/NCT01128894?term=01128894&rank=1. Accessed 25 Oct 2015.
    • GlaxoSmithKline
  • 22
    • 84975641905 scopus 로고    scopus 로고
    • GlaxoSmithKline. A study to determine the safety and efficacy of albiglutide in patients with type 2 diabetes. Accessed 25 Oct 2015
    • GlaxoSmithKline. A study to determine the safety and efficacy of albiglutide in patients with type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT00838916?term=00838916&rank=1. Accessed 25 Oct 2015.
  • 23
    • 84975660652 scopus 로고    scopus 로고
    • GlaxoSmithKline. A study to determine the safety and efficacy of albiglutide in subjects with type 2 diabetes. Accessed 25 Oct 2015
    • GlaxoSmithKline. A study to determine the safety and efficacy of albiglutide in subjects with type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT00839527?term=00839527&rank=1. Accessed 25 Oct 2015.
  • 24
    • 84975628433 scopus 로고    scopus 로고
    • Efficacy and safety of albiglutide in treatment of type 2 diabetes
    • Accessed 25 Oct 2015
    • GlaxoSmithKline. Efficacy and safety of albiglutide in treatment of type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT00838903?term=00838903&rank=1. Accessed 25 Oct 2015.
    • GlaxoSmithKline
  • 25
    • 84975593101 scopus 로고    scopus 로고
    • GlaxoSmithKline. A study to determine the safety and efficacy of albiglutide administered in combination with insulin glargine. Accessed 25 Oct 2015
    • GlaxoSmithKline. A study to determine the safety and efficacy of albiglutide administered in combination with insulin glargine. https://clinicaltrials.gov/ct2/show/NCT00976391?term=00976391&rank=1. Accessed 25 Oct 2015.
  • 26
    • 84975628440 scopus 로고    scopus 로고
    • GlaxoSmithKline. Safety and efficacy of albiglutide in type 2 diabetes. Accessed 25 Oct 2015
    • GlaxoSmithKline. Safety and efficacy of albiglutide in type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT00849056?term=00849056&rank=1. Accessed 25 Oct 2015.
  • 27
    • 84975628446 scopus 로고    scopus 로고
    • Effects of exenatide long-acting release on glucose control and safety in subjects with type 2 diabetes mellitus (DURATION-1)
    • Accessed 25 Oct 2015
    • AstraZeneca. Effects of exenatide long-acting release on glucose control and safety in subjects with type 2 diabetes mellitus (DURATION-1). https://clinicaltrials.gov/ct2/show/NCT00308139?term=00308139&rank=1. Accessed 25 Oct 2015.
    • AstraZeneca
  • 28
    • 84975670578 scopus 로고    scopus 로고
    • AstraZeneca. Comparison study of the glycemic effects, safety, and tolerability of exenatide once weekly suspension to sitagliptin and placebo in subjects with type 2 diabetes mellitus (DURATION-NEO-2). Accessed 25 Oct 2015
    • AstraZeneca. Comparison study of the glycemic effects, safety, and tolerability of exenatide once weekly suspension to sitagliptin and placebo in subjects with type 2 diabetes mellitus (DURATION-NEO-2). https://clinicaltrials.gov/ct2/show/NCT01652729?term=NCT01652729&rank=1. Accessed 25 Oct 2015.
  • 29
    • 84975617073 scopus 로고    scopus 로고
    • AstraZeneca. Safety and efficacy of exenatide once weekly injection versus metformin, dipeptidyl peptidase-4 inhibitor, or thiazolidinedione as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4). Accessed 25 Oct 2015
    • AstraZeneca. Safety and efficacy of exenatide once weekly injection versus metformin, dipeptidyl peptidase-4 inhibitor, or thiazolidinedione as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4). https://clinicaltrials.gov/ct2/show/NCT00676338?term=00676338&rank=1. Accessed 25 Oct 2015.
  • 30
    • 84975672443 scopus 로고    scopus 로고
    • AstraZeneca. Safety and efficacy of exenatide once weekly versus liraglutide in subjects with type 2 diabetes. Accessed 25 Oct 2015
    • AstraZeneca. Safety and efficacy of exenatide once weekly versus liraglutide in subjects with type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT01029886?term=01029886&rank=1. Accessed 25 Oct 2015.
  • 31
    • 84975660659 scopus 로고    scopus 로고
    • Efficacy of once-weekly exenatide versus once or twice daily insulin detemir in patients with type 2 diabetes
    • Accessed 25 Oct 2015
    • AstraZeneca. Efficacy of once-weekly exenatide versus once or twice daily insulin detemir in patients with type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT01003184?term=01003184&rank=1. Accessed 25 Oct 2015.
    • AstraZeneca
  • 32
    • 84975660649 scopus 로고    scopus 로고
    • AstraZeneca. A study to compare the glycemic effects, safety, and tolerability of exenatide once weekly to those of sitagliptin and pioglitazone,in subjects with type 2 diabetes treated with metformin (DURATION-2). Accessed 25 Oct 2015
    • AstraZeneca. A study to compare the glycemic effects, safety, and tolerability of exenatide once weekly to those of sitagliptin and pioglitazone,in subjects with type 2 diabetes treated with metformin (DURATION-2). https://clinicaltrials.gov/ct2/show/NCT00637273?term=00637273&rank=1. Accessed 25 Oct 2015.
  • 33
    • 84975670563 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study comparing the effect of dulaglutide with liraglutide in type 2 diabetes (AWARD-6). Accessed 25 Oct 2015
    • Eli Lilly and Company. A study comparing the effect of dulaglutide with liraglutide in type 2 diabetes (AWARD-6). https://clinicaltrials.gov/ct2/show/NCT01624259?term=01624259&rank=1. Accessed 25 Oct 2015.
  • 34
    • 84975642296 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study of dulaglutide in Japanese participants with type 2 diabetes mellitus. Accessed 25 Oct 2015
    • Eli Lilly and Company. A study of dulaglutide in Japanese participants with type 2 diabetes mellitus. https://clinicaltrials.gov/ct2/show/NCT01584232?term=01584232&rank=1. Accessed 25 Oct 2015.
  • 35
    • 84975642305 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study of LY2189265 compared to sitagliptin in participants with type 2 diabetes mellitus on metformin. Accessed 25 Oct 2015
    • Eli Lilly and Company. A study of LY2189265 compared to sitagliptin in participants with type 2 diabetes mellitus on metformin. https://clinicaltrials.gov/ct2/show/NCT00734474?term=00734474&rank=1. Accessed 25 Oct 2015.
  • 36
    • 84975617068 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-2). Accessed 25 Oct 2015
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-2). https://clinicaltrials.gov/ct2/show/NCT01075282?term=01075282&rank=1. Accessed 25 Oct 2015.
  • 37
    • 84975642310 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-4). Accessed 25 Oct 2015
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-4). https://clinicaltrials.gov/ct2/show/NCT01191268?term=01191268&rank=1. Accessed 25 Oct 2015.
  • 38
    • 84975642300 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-3). Accessed 25 Oct 2015
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-3). https://clinicaltrials.gov/ct2/show/NCT01126580?term=01126580&rank=1. Accessed 25 Oct 2015.
  • 39
    • 84975630347 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study of LY2189265 in Japanese participants with type 2 diabetes mellitus. Accessed 25 Oct 2015
    • Eli Lilly and Company. A study of LY2189265 in Japanese participants with type 2 diabetes mellitus. https://clinicaltrials.gov/ct2/show/NCT01558271?term=01558271&rank=1. Accessed 25 Oct 2015.
  • 40
    • 84975630351 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study of the effect of LY2189265 on blood pressure and heart rate in type 2 diabetes. Accessed 25 Oct 2015
    • Eli Lilly and Company. A study of the effect of LY2189265 on blood pressure and heart rate in type 2 diabetes. https://clinicaltrials.gov/ct2/show/NCT01149421?term=01149421&rank=1. Accessed 25 Oct 2015.
  • 41
    • 84894283960 scopus 로고    scopus 로고
    • A study of dose titration of LY2189265 in overweight participants with type 2 diabetes mellitus (EGO). Accessed 25 Oct 2015
    • Eli Lilly and Company. A study of dose titration of LY2189265 in overweight participants with type 2 diabetes mellitus (EGO). https://clinicaltrials.gov/ct2/show/NCT00630825?term=00630825&rank=1. Accessed 25 Oct 2015.
    • Eli Lilly and Company
  • 42
    • 84894283960 scopus 로고    scopus 로고
    • A study in participants with type 2 diabetes mellitus (AWARD-1). Accessed 25 Oct 2015
    • Eli Lilly and Company. A study in participants with type 2 diabetes mellitus (AWARD-1). https://clinicaltrials.gov/ct2/show/NCT01064687?term=01064687&rank=1. Accessed 25 Oct 2015.
    • Eli Lilly and Company
  • 43
    • 84975636893 scopus 로고    scopus 로고
    • Eli Lilly and Company. A study comparing the effects and safety of dulaglutide with insulin glargine in type 2 diabetes mellitus. Accessed 25 Oct 2015
    • Eli Lilly and Company. A study comparing the effects and safety of dulaglutide with insulin glargine in type 2 diabetes mellitus. https://clinicaltrials.gov/ct2/show/NCT01648582?term=NCT01648582&rank=1. Accessed 25 Oct 2015.
  • 44
    • 84975640097 scopus 로고    scopus 로고
    • Department of Food and Drug Administration
    • U.S. Department of Food and Drug Administration. Adverse Event Reporting System [Internet], 2011. http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/default.htm. Accessed 31 Mar 2014.
    • (2011) Adverse Event Reporting System [Internet]
  • 45
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • COI: 1:CAS:528:DC%2BC3MXosVGnsrY%3D, PID: 21334333
    • Elashoff M, Matveyenko AV, Gier B, et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology. 2011;141:150–6.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3
  • 46
    • 72449148137 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?
    • COI: 1:STN:280:DC%2BC3c%2FjvVyitA%3D%3D, PID: 19894028
    • Butler PC, Matveyenko AV, Dry S, et al. Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire? Diabetologia. 2010;53:1–6.
    • (2010) Diabetologia , vol.53 , pp. 1-6
    • Butler, P.C.1    Matveyenko, A.V.2    Dry, S.3
  • 47
    • 84860567470 scopus 로고    scopus 로고
    • Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D)mouse model
    • COI: 1:CAS:528:DC%2BC38XmtlyhtL0%3D, PID: 22266668
    • Gier B, Matveyenko AV, Kirakossian D, et al. Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D)mouse model. Diabetes. 2012;61:1250–62.
    • (2012) Diabetes , vol.61 , pp. 1250-1262
    • Gier, B.1    Matveyenko, A.V.2    Kirakossian, D.3
  • 48
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • PID: 20203154
    • Bjerre Knudsen L, Madsen LW, et al. Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology. 2010;151:1473–86.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Bjerre Knudsen, L.1    Madsen, L.W.2
  • 49
    • 84908627961 scopus 로고    scopus 로고
    • Exendin-4, a GLP-1 receptor agonist, attenuates prostate cancer growth
    • COI: 1:CAS:528:DC%2BC2cXhvVygsr%2FL, PID: 24879833
    • Nomiyama T, Kawanami T, Irie S, et al. Exendin-4, a GLP-1 receptor agonist, attenuates prostate cancer growth. Diabetes. 2014;63(11):3891–905.
    • (2014) Diabetes , vol.63 , Issue.11 , pp. 3891-3905
    • Nomiyama, T.1    Kawanami, T.2    Irie, S.3
  • 50
    • 80052483571 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon cancer cells
    • COI: 1:CAS:528:DC%2BC3MXhtFOht7nJ, PID: 21771884
    • Koehler JA, Kain T, Drucker DJ. Glucagon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon cancer cells. Endocrinology. 2011;152(9):3362–72.
    • (2011) Endocrinology , vol.152 , Issue.9 , pp. 3362-3372
    • Koehler, J.A.1    Kain, T.2    Drucker, D.J.3
  • 51
    • 84859104912 scopus 로고    scopus 로고
    • The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells
    • COI: 1:CAS:528:DC%2BC38XktFOjtb8%3D, PID: 21638053
    • Ligumsky H, Wolf I, Israeli S, et al. The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells. Breast Cancer Res Treat. 2012;132:449–61.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 449-461
    • Ligumsky, H.1    Wolf, I.2    Israeli, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.