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Volumn 11, Issue 2, 2016, Pages 255-262

Carfilzomib Triple Combination Therapy: A Review in Relapsed Multiple Myeloma

Author keywords

[No Author keywords available]

Indexed keywords

CARFILZOMIB; DEXAMETHASONE; LENALIDOMIDE; OLIGOPEPTIDE;

EID: 84961163929     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-016-0428-7     Document Type: Article
Times cited : (13)

References (26)
  • 2
    • 84946488747 scopus 로고    scopus 로고
    • Defining and treating high-risk multiple myeloma
    • COI: 1:CAS:528:DC%2BC2MXhsV2jsLrO, PID: 26265183
    • Usmani SZ, Rodriguez-Otero P, Bhutani M, et al. Defining and treating high-risk multiple myeloma. Leukemia. 2015;29(11):2119–25.
    • (2015) Leukemia , vol.29 , Issue.11 , pp. 2119-2125
    • Usmani, S.Z.1    Rodriguez-Otero, P.2    Bhutani, M.3
  • 3
    • 84927177719 scopus 로고    scopus 로고
    • Current treatment landscape for relapsed and/or refractory multiple myeloma
    • COI: 1:CAS:528:DC%2BC2cXhvF2nu7fM, PID: 25421279
    • Dimopoulos MA, Richardson PG, Moreau P, et al. Current treatment landscape for relapsed and/or refractory multiple myeloma. Nat Rev Clin Oncol. 2015;12(1):42–54.
    • (2015) Nat Rev Clin Oncol , vol.12 , Issue.1 , pp. 42-54
    • Dimopoulos, M.A.1    Richardson, P.G.2    Moreau, P.3
  • 4
    • 84962323101 scopus 로고    scopus 로고
    • KYPROLIS® (carfilzomib) for injection
    • Onynx Pharmaceuticals Inc. KYPROLIS® (carfilzomib) for injection, for intravenous use: US prescribing information. 2016. http://www.fda.gov/drugsatfda. Accessed 5 Feb 2016.
    • (2016) for intravenous use: US prescribing information
  • 5
    • 81055149914 scopus 로고    scopus 로고
    • Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma
    • COI: 1:CAS:528:DC%2BC3MXhsVeltLbJ, PID: 22072815
    • Hideshima T, Richardson PG, Anderson KC. Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma. Mol Cancer Ther. 2011;10(11):2034–42.
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 , pp. 2034-2042
    • Hideshima, T.1    Richardson, P.G.2    Anderson, K.C.3
  • 6
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXht1yqur3L, PID: 17591945
    • Kuhn DJ, Chen Q, Voorhees PM, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood. 2007;110(9):3281–90.
    • (2007) Blood , vol.110 , Issue.9 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3
  • 7
    • 34447116376 scopus 로고    scopus 로고
    • Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
    • COI: 1:CAS:528:DC%2BD2sXnsVyqtLY%3D, PID: 17616698
    • Demo SD, Kirk CJ, Aujay MA, et al. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res. 2007;67(13):6383–91.
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3
  • 8
    • 84962244501 scopus 로고    scopus 로고
    • Amgen Europe B.V. Kyprolis (carfilzomib) 60 mg powder for solution for infusion: EU summary of product characteristics. 2015. Accessed 5 Feb 2016
    • Amgen Europe B.V. Kyprolis (carfilzomib) 60 mg powder for solution for infusion: EU summary of product characteristics. 2015. http://www.ema.europa.eu/ema/. Accessed 5 Feb 2016.
  • 9
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • COI: 1:CAS:528:DC%2BD1MXhtlensb7L, PID: 19671918
    • Parlati F, Lee SJ, Aujay M, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009;114(16):3439–47.
    • (2009) Blood , vol.114 , Issue.16 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3
  • 10
    • 84865712581 scopus 로고    scopus 로고
    • A phase I single-agent study of twice-weekly consecutive-day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma
    • COI: 1:CAS:528:DC%2BC38Xht1ygsbzE, PID: 22761464
    • Alsina M, Trudel S, Furman RR, et al. A phase I single-agent study of twice-weekly consecutive-day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma. Clin Cancer Res. 2012;18(17):4830–40.
    • (2012) Clin Cancer Res , vol.18 , Issue.17 , pp. 4830-4840
    • Alsina, M.1    Trudel, S.2    Furman, R.R.3
  • 11
    • 84877089105 scopus 로고    scopus 로고
    • Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXlvFyjtr0%3D, PID: 23447001
    • Niesvizky R, Martin 3rd TG, Bensinger WI, et al. Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Clin Cancer Res. 2013;19(8):2248–56.
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 2248-2256
    • Niesvizky, R.1    Martin, T.G.2    Bensinger, W.I.3
  • 12
    • 84887609779 scopus 로고    scopus 로고
    • Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXhslGhtbfI, PID: 24014245
    • Wang M, Martin T, Bensinger W, et al. Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Blood. 2013;122(18):3122–8.
    • (2013) Blood , vol.122 , Issue.18 , pp. 3122-3128
    • Wang, M.1    Martin, T.2    Bensinger, W.3
  • 13
    • 84865333050 scopus 로고    scopus 로고
    • A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
    • COI: 1:CAS:528:DC%2BC38XhtlChtLvE, PID: 22665938
    • Jakubowiak AJ, Dytfeld D, Griffith KA, et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Blood. 2012;120(9):1801–9.
    • (2012) Blood , vol.120 , Issue.9 , pp. 1801-1809
    • Jakubowiak, A.J.1    Dytfeld, D.2    Griffith, K.A.3
  • 14
    • 84920599743 scopus 로고    scopus 로고
    • Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma
    • PID: 25482145, plus supplementary appendix
    • Stewart AK, Rajkumar SV, Dimopoulos MA, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015;372(2):142–52. plus supplementary appendix.
    • (2015) N Engl J Med , vol.372 , Issue.2 , pp. 142-152
    • Stewart, A.K.1    Rajkumar, S.V.2    Dimopoulos, M.A.3
  • 15
    • 84944463316 scopus 로고    scopus 로고
    • Carfilzomib enhances natural killer cell-mediated lysis of myeloma linked with decreasing expression of HLA class I
    • PID: 26323098
    • Yang G, Gao M, Zhang Y, et al. Carfilzomib enhances natural killer cell-mediated lysis of myeloma linked with decreasing expression of HLA class I. Oncotarget. 2015;6(29):26982–94.
    • (2015) Oncotarget , vol.6 , Issue.29 , pp. 26982-26994
    • Yang, G.1    Gao, M.2    Zhang, Y.3
  • 16
    • 84884200814 scopus 로고    scopus 로고
    • Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXhsFWqsLvP, PID: 24066119
    • Hu B, Chen Y, Usmani SZ, et al. Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma. PLoS ONE. 2013;8(9): e74191.
    • (2013) PLoS ONE , vol.8 , Issue.9
    • Hu, B.1    Chen, Y.2    Usmani, S.Z.3
  • 17
    • 84881480747 scopus 로고    scopus 로고
    • Carfilzomib in multiple myeloma patients with renal impairment: pharmacokinetics and safety
    • COI: 1:CAS:528:DC%2BC3sXht1GgsrjL, PID: 23364621
    • Badros AZ, Vij R, Martin T, et al. Carfilzomib in multiple myeloma patients with renal impairment: pharmacokinetics and safety. Leukemia. 2013;27(8):1707–14.
    • (2013) Leukemia , vol.27 , Issue.8 , pp. 1707-1714
    • Badros, A.Z.1    Vij, R.2    Martin, T.3
  • 18
    • 84962286528 scopus 로고    scopus 로고
    • European Medicines Agency. Kyprolis (carfilzomib): assessment report. 2015. Accessed 5 Feb 2016
    • European Medicines Agency. Kyprolis (carfilzomib): assessment report. 2015. http://www.ema.europa.eu/ema/. Accessed 5 Feb 2016.
  • 19
    • 84962215739 scopus 로고    scopus 로고
    • Dimopoulos MA, Stewart AK, Rajkumar SV, et al. Effect of carfilzomib, lenalidomide, and dexamethasone (KRd) vs lenalidomide and dexamethasone (Rd) in patients with relapsed multiple myeloma (RMM) by line of therapy: secondary analysis from an interim analysis of the phase III study ASPIRE (NCT01080391) [abstract no. 8525 plus poster]. J Clin Oncol. 2015;33(Suppl)
    • Dimopoulos MA, Stewart AK, Rajkumar SV, et al. Effect of carfilzomib, lenalidomide, and dexamethasone (KRd) vs lenalidomide and dexamethasone (Rd) in patients with relapsed multiple myeloma (RMM) by line of therapy: secondary analysis from an interim analysis of the phase III study ASPIRE (NCT01080391) [abstract no. 8525 plus poster]. J Clin Oncol. 2015;33(Suppl).
  • 20
    • 84962217268 scopus 로고    scopus 로고
    • Superior health-related quality of life with carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patients with relapsed multiple myeloma (MM): results from the ASPIRE trial
    • Stewart AK, Dimopoulos MA, Masszi T, et al. Superior health-related quality of life with carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patients with relapsed multiple myeloma (MM): results from the ASPIRE trial. Clin Lymphoma Myeloma Leuk. 2015;15 Suppl 3: e76.
    • (2015) Clin Lymphoma Myeloma Leuk , vol.15
    • Stewart, A.K.1    Dimopoulos, M.A.2    Masszi, T.3
  • 21
    • 84885367423 scopus 로고    scopus 로고
    • Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • PID: 23956208
    • Moreau P, San Miguel J, Ludwig H, et al. Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 Suppl 6:vi133-7.
    • (2013) Ann Oncol , vol.24
    • Moreau, P.1    San Miguel, J.2    Ludwig, H.3
  • 22
    • 84962237878 scopus 로고    scopus 로고
    • Indirect comparisons to assess the relative efficacy of carfilzomib + lenalidomide + dexamethasone versus panobinostat + bortezomib + dexamethasone and bortezomib + dexamethasone: a matching adjusted indirect comparison [abstract]
    • Rael M, Benedict A, Ishak J, et al. Indirect comparisons to assess the relative efficacy of carfilzomib + lenalidomide + dexamethasone versus panobinostat + bortezomib + dexamethasone and bortezomib + dexamethasone: a matching adjusted indirect comparison [abstract]. Blood. 2015;126(23):5622.
    • (2015) Blood , vol.126 , Issue.23 , pp. 5622
    • Rael, M.1    Benedict, A.2    Ishak, J.3
  • 23
    • 84962237878 scopus 로고    scopus 로고
    • Indirect comparison to assess the relative efficacy of carfilzomib + lenalidomide + dexamethasone versus bortezomib + thalidomide + dexamethasone: a matching adjusted indirect comparison [abstract]
    • Rael M, Benedict A, Ishak J, et al. Indirect comparison to assess the relative efficacy of carfilzomib + lenalidomide + dexamethasone versus bortezomib + thalidomide + dexamethasone: a matching adjusted indirect comparison [abstract]. Blood. 2015;126(23):5624.
    • (2015) Blood , vol.126 , Issue.23 , pp. 5624
    • Rael, M.1    Benedict, A.2    Ishak, J.3
  • 24
    • 84962214833 scopus 로고    scopus 로고
    • US National Institutes of Health. ClinicalTrials.gov. 2016. Accessed 5 Feb 2016
    • US National Institutes of Health. ClinicalTrials.gov. 2016. http://www.clinicaltrials.gov. Accessed 5 Feb 2016.
  • 25
    • 84955420512 scopus 로고    scopus 로고
    • Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study
    • COI: 1:CAS:528:DC%2BC2MXhvFKkt73O, PID: 26671818
    • Dimopoulos MA, Moreau P, Palumbo A, et al. Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study. Lancet Oncol. 2016;17(1):27–38.
    • (2016) Lancet Oncol , vol.17 , Issue.1 , pp. 27-38
    • Dimopoulos, M.A.1    Moreau, P.2    Palumbo, A.3
  • 26
    • 84962320889 scopus 로고    scopus 로고
    • Amgen. Amgen submits application in Europe to expand indication of Kyprolis® (carfilzomib) for the treatment of relapsed multiple myeloma [media release]. 2015
    • Amgen. Amgen submits application in Europe to expand indication of Kyprolis® (carfilzomib) for the treatment of relapsed multiple myeloma [media release]. 2015. http://wwwext.amgen.com/media/.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.