메뉴 건너뛰기




Volumn 58, Issue , 2016, Pages 88-100

Sex and age specific effects of delta-9-tetrahydrocannabinol during the periadolescent period in the rat: The unique susceptibility of the prepubescent animal

Author keywords

CB1 receptor expression; Corticosterone; Delta 9 tetrahydrocannabinol; Emotionality; Puberty; Sex differences

Indexed keywords

CANNABINOID RECEPTOR; CORTICOSTERONE; DRONABINOL; MESSENGER RNA; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CANNABINOID 1 RECEPTOR;

EID: 84961116630     PISSN: 08920362     EISSN: 18729738     Source Type: Journal    
DOI: 10.1016/j.ntt.2016.02.005     Document Type: Review
Times cited : (49)

References (63)
  • 1
    • 75949092239 scopus 로고    scopus 로고
    • Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission
    • Bambico, F.R., Nguyen, N.T., Katz, N., Gobbi, G., Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission. Neurobiol. Dis. 37 (2010), 641–655.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 641-655
    • Bambico, F.R.1    Nguyen, N.T.2    Katz, N.3    Gobbi, G.4
  • 2
    • 0033198288 scopus 로고    scopus 로고
    • Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period
    • Berrendero, F., Sepe, N., Ramos, J.A., Di Marzo, V., Fernandez-Ruiz, J.J., Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period. Synapse 33 (1999), 181–191.
    • (1999) Synapse , vol.33 , pp. 181-191
    • Berrendero, F.1    Sepe, N.2    Ramos, J.A.3    Di Marzo, V.4    Fernandez-Ruiz, J.J.5
  • 3
    • 0344082222 scopus 로고    scopus 로고
    • Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood
    • Biscaia, M., Marin, S., Fernandez, B., Marco, E.M., Rubio, M., Guaza, C., Ambrosio, E., Viveros, M.P., Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood. Psychopharmacology 170 (2003), 301–308.
    • (2003) Psychopharmacology , vol.170 , pp. 301-308
    • Biscaia, M.1    Marin, S.2    Fernandez, B.3    Marco, E.M.4    Rubio, M.5    Guaza, C.6    Ambrosio, E.7    Viveros, M.P.8
  • 4
    • 1842734292 scopus 로고    scopus 로고
    • Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats
    • Brake, W.G., Zhang, T.Y., Diorio, J., Meaney, M.J., Gratton, A., Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats. Eur. J. Neurosci. 19 (2004), 1863–1874.
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 1863-1874
    • Brake, W.G.1    Zhang, T.Y.2    Diorio, J.3    Meaney, M.J.4    Gratton, A.5
  • 5
    • 77955821289 scopus 로고    scopus 로고
    • Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure
    • Burston, J.J., Wiley, J.L., Craig, A.A., Selley, D.E., Sim-Selley, L.J., Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure. Br. J. Pharmacol. 161 (2010), 103–112.
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 103-112
    • Burston, J.J.1    Wiley, J.L.2    Craig, A.A.3    Selley, D.E.4    Sim-Selley, L.J.5
  • 6
    • 0022916927 scopus 로고
    • Delta 9-tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus
    • Campbell, K.A., Foster, T.C., Hampson, R.E., Deadwyler, S.A., Delta 9-tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus. J. Pharmacol. Exp. Ther. 239 (1986), 936–940.
    • (1986) J. Pharmacol. Exp. Ther. , vol.239 , pp. 936-940
    • Campbell, K.A.1    Foster, T.C.2    Hampson, R.E.3    Deadwyler, S.A.4
  • 7
    • 77649153326 scopus 로고    scopus 로고
    • Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat
    • e8618
    • Castro, J.E., Varea, E., Marquez, C., Cordero, M.I., Poirier, G., Sandi, C., Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat. PLoS One, 5, 2010, e8618.
    • (2010) PLoS One , vol.5
    • Castro, J.E.1    Varea, E.2    Marquez, C.3    Cordero, M.I.4    Poirier, G.5    Sandi, C.6
  • 10
    • 0035985555 scopus 로고    scopus 로고
    • Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment
    • Ellenbroek, B.A., Cools, A.R., Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment. Pharmacol. Biochem. Behav. 73 (2002), 177–184.
    • (2002) Pharmacol. Biochem. Behav. , vol.73 , pp. 177-184
    • Ellenbroek, B.A.1    Cools, A.R.2
  • 11
    • 33847008322 scopus 로고    scopus 로고
    • Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats
    • Ellgren, M., Spano, S.M., Hurd, Y.L., Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats. Neuropsychopharmacology 32 (2007), 607–615.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 607-615
    • Ellgren, M.1    Spano, S.M.2    Hurd, Y.L.3
  • 12
    • 84863511021 scopus 로고    scopus 로고
    • Type-1 cannabinoid receptor signaling in neuronal development
    • Gaffuri, A.L., Ladarre, D., Lenkei, Z., Type-1 cannabinoid receptor signaling in neuronal development. Pharmacology 90 (2012), 19–39.
    • (2012) Pharmacology , vol.90 , pp. 19-39
    • Gaffuri, A.L.1    Ladarre, D.2    Lenkei, Z.3
  • 13
    • 0031047273 scopus 로고    scopus 로고
    • Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain
    • Glass, M., Dragunow, M., Faull, R.L., Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 77 (1997), 299–318.
    • (1997) Neuroscience , vol.77 , pp. 299-318
    • Glass, M.1    Dragunow, M.2    Faull, R.L.3
  • 14
    • 0037255987 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of cannabinoids
    • Grotenhermen, F., Pharmacokinetics and pharmacodynamics of cannabinoids. Clin. Pharmacokinet. 42 (2003), 327–360.
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 327-360
    • Grotenhermen, F.1
  • 15
    • 70349859637 scopus 로고    scopus 로고
    • Adverse health effects of non-medical cannabis use
    • Hall, W., Degenhardt, L., Adverse health effects of non-medical cannabis use. Lancet 374 (2009), 1383–1391.
    • (2009) Lancet , vol.374 , pp. 1383-1391
    • Hall, W.1    Degenhardt, L.2
  • 16
    • 84857135537 scopus 로고    scopus 로고
    • Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
    • Haring, M., Guggenhuber, S., Lutz, B., Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. Neuroscience 204 (2012), 145–158.
    • (2012) Neuroscience , vol.204 , pp. 145-158
    • Haring, M.1    Guggenhuber, S.2    Lutz, B.3
  • 17
    • 84859077105 scopus 로고    scopus 로고
    • Withdrawal from THC during adolescence: sex differences in locomotor activity and anxiety
    • Harte-Hargrove, L.C., Dow-Edwards, D.L., Withdrawal from THC during adolescence: sex differences in locomotor activity and anxiety. Behav. Brain Res. 231 (2012), 48–59.
    • (2012) Behav. Brain Res. , vol.231 , pp. 48-59
    • Harte-Hargrove, L.C.1    Dow-Edwards, D.L.2
  • 18
    • 68049107192 scopus 로고    scopus 로고
    • Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory
    • Higuera-Matas, A., Botreau, F., Miguens, M., Del Olmo, N., Borcel, E., Perez-Alvarez, L., Garcia-Lecumberri, C., Ambrosio, E., Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory. Pharmacol. Biochem. Behav. 93 (2009), 482–490.
    • (2009) Pharmacol. Biochem. Behav. , vol.93 , pp. 482-490
    • Higuera-Matas, A.1    Botreau, F.2    Miguens, M.3    Del Olmo, N.4    Borcel, E.5    Perez-Alvarez, L.6    Garcia-Lecumberri, C.7    Ambrosio, E.8
  • 19
    • 84922741113 scopus 로고    scopus 로고
    • Stress regulates endocannabinoid-CB1 receptor signaling
    • Hillard, C.J., Stress regulates endocannabinoid-CB1 receptor signaling. Semin. Immunol. 26 (2014), 380–388.
    • (2014) Semin. Immunol. , vol.26 , pp. 380-388
    • Hillard, C.J.1
  • 20
    • 0037208865 scopus 로고    scopus 로고
    • In situ hybridization with isotopic riboprobes for detection of striatal neuropeptide mRNA expression after dopamine stimulant administration
    • Hurd, Y.L., In situ hybridization with isotopic riboprobes for detection of striatal neuropeptide mRNA expression after dopamine stimulant administration. Methods Mol. Med. 79 (2003), 119–135.
    • (2003) Methods Mol. Med. , vol.79 , pp. 119-135
    • Hurd, Y.L.1
  • 21
    • 0014981353 scopus 로고
    • The metabolism and excretion of delta 9-tetrahydrocannabinol in the rat
    • Klausner, H.A., Dingell, J.V., The metabolism and excretion of delta 9-tetrahydrocannabinol in the rat. Life Sci. Pt 1: Physiol. Pharmacol. 10 (1971), 49–59.
    • (1971) Life Sci. Pt 1: Physiol. Pharmacol. , vol.10 , pp. 49-59
    • Klausner, H.A.1    Dingell, J.V.2
  • 22
    • 66449101272 scopus 로고    scopus 로고
    • Reduced behavioral response to gonadal hormones in mice shipped during the peripubertal/adolescent period
    • Laroche, J., Gasbarro, L., Herman, J.P., Blaustein, J.D., Reduced behavioral response to gonadal hormones in mice shipped during the peripubertal/adolescent period. Endocrinology 150 (2009), 2351–2358.
    • (2009) Endocrinology , vol.150 , pp. 2351-2358
    • Laroche, J.1    Gasbarro, L.2    Herman, J.P.3    Blaustein, J.D.4
  • 23
    • 84857124882 scopus 로고    scopus 로고
    • Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods
    • Lee, T.T., Gorzalka, B.B., Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods. Neuroscience 204 (2012), 17–30.
    • (2012) Neuroscience , vol.204 , pp. 17-30
    • Lee, T.T.1    Gorzalka, B.B.2
  • 25
    • 84924170953 scopus 로고    scopus 로고
    • The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations
    • Maccari, S., Krugers, H.J., Morley-Fletcher, S., Szyf, M., Brunton, P.J., The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. J. Neuroendocrinol. 26 (2014), 707–723.
    • (2014) J. Neuroendocrinol. , vol.26 , pp. 707-723
    • Maccari, S.1    Krugers, H.J.2    Morley-Fletcher, S.3    Szyf, M.4    Brunton, P.J.5
  • 26
    • 84856087671 scopus 로고    scopus 로고
    • Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors
    • Mateos, B., Borcel, E., Loriga, R., Luesu, W., Bini, V., Llorente, R., Castelli, M.P., Viveros, M.P., Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors. J. Psychopharmacol. 25 (2011), 1676–1690.
    • (2011) J. Psychopharmacol. , vol.25 , pp. 1676-1690
    • Mateos, B.1    Borcel, E.2    Loriga, R.3    Luesu, W.4    Bini, V.5    Llorente, R.6    Castelli, M.P.7    Viveros, M.P.8
  • 27
    • 84857128132 scopus 로고    scopus 로고
    • Cannabinoids and emotionality: a neuroanatomical perspective
    • McLaughlin, R.J., Gobbi, G., Cannabinoids and emotionality: a neuroanatomical perspective. Neuroscience 204 (2012), 134–144.
    • (2012) Neuroscience , vol.204 , pp. 134-144
    • McLaughlin, R.J.1    Gobbi, G.2
  • 28
    • 85015555601 scopus 로고    scopus 로고
    • Cannabis use in first episode psychosis: meta-analysis of prevalence, and the time course of initiation and continued use
    • Myles, H., Myles, N., Large, M., Cannabis use in first episode psychosis: meta-analysis of prevalence, and the time course of initiation and continued use. Aust. N. Z. J. Psychiatry, 2015.
    • (2015) Aust. N. Z. J. Psychiatry
    • Myles, H.1    Myles, N.2    Large, M.3
  • 29
    • 0037164359 scopus 로고    scopus 로고
    • Cannabis use and mental health in young people: cohort study
    • Patton, G.C., Coffey, C., Carlin, J.B., Degenhardt, L., Lynskey, M., Hall, W., Cannabis use and mental health in young people: cohort study. BMJ 325 (2002), 1195–1198.
    • (2002) BMJ , vol.325 , pp. 1195-1198
    • Patton, G.C.1    Coffey, C.2    Carlin, J.B.3    Degenhardt, L.4    Lynskey, M.5    Hall, W.6
  • 30
    • 85000940179 scopus 로고    scopus 로고
    • The rat brain in stereotaxic coordinates
    • Academic Press/Elsevier Amsterdam; Boston
    • Paxinos, G., Watson, C., The rat brain in stereotaxic coordinates. 2007, Academic Press/Elsevier, Amsterdam; Boston.
    • (2007)
    • Paxinos, G.1    Watson, C.2
  • 31
    • 0018268297 scopus 로고
    • Behavioural despair in rats: a new model sensitive to antidepressant treatments
    • Porsolt, R.D., Anton, G., Blavet, N., Jalfre, M., Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47 (1978), 379–391.
    • (1978) Eur. J. Pharmacol. , vol.47 , pp. 379-391
    • Porsolt, R.D.1    Anton, G.2    Blavet, N.3    Jalfre, M.4
  • 32
    • 33749314873 scopus 로고    scopus 로고
    • The acute effects of cannabinoids on memory in humans: a review
    • Ranganathan, M., D'Souza, D.C., The acute effects of cannabinoids on memory in humans: a review. Psychopharmacology 188 (2006), 425–444.
    • (2006) Psychopharmacology , vol.188 , pp. 425-444
    • Ranganathan, M.1    D'Souza, D.C.2
  • 33
    • 39149137167 scopus 로고    scopus 로고
    • Acoustic startle amplitude predicts vulnerability to develop post-traumatic stress hyper-responsivity and associated plasma corticosterone changes in rats
    • Rasmussen, D.D., Crites, N.J., Burke, B.L., Acoustic startle amplitude predicts vulnerability to develop post-traumatic stress hyper-responsivity and associated plasma corticosterone changes in rats. Psychoneuroendocrinology 33 (2008), 282–291.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 282-291
    • Rasmussen, D.D.1    Crites, N.J.2    Burke, B.L.3
  • 34
    • 78650824265 scopus 로고    scopus 로고
    • Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats
    • Realini, N., Vigano, D., Guidali, C., Zamberletti, E., Rubino, T., Parolaro, D., Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats. Neuropharmacology 60 (2011), 235–243.
    • (2011) Neuropharmacology , vol.60 , pp. 235-243
    • Realini, N.1    Vigano, D.2    Guidali, C.3    Zamberletti, E.4    Rubino, T.5    Parolaro, D.6
  • 35
    • 84949117809 scopus 로고    scopus 로고
    • Long-term consequences of adolescent cannabinoid exposure in adult psychopathology
    • Renard, J., Krebs, M.O., Le Pen, G., Jay, T.M., Long-term consequences of adolescent cannabinoid exposure in adult psychopathology. Front. Neurosci., 8, 2014, 361.
    • (2014) Front. Neurosci. , vol.8 , pp. 361
    • Renard, J.1    Krebs, M.O.2    Le Pen, G.3    Jay, T.M.4
  • 37
  • 38
    • 2342598541 scopus 로고    scopus 로고
    • Testosterone cannot activate an adult-like stress response in prepubertal male rats
    • Romeo, R.D., Lee, S.J., Chhua, N., McPherson, C.R., McEwen, B.S., Testosterone cannot activate an adult-like stress response in prepubertal male rats. Neuroendocrinology 79 (2004), 125–132.
    • (2004) Neuroendocrinology , vol.79 , pp. 125-132
    • Romeo, R.D.1    Lee, S.J.2    Chhua, N.3    McPherson, C.R.4    McEwen, B.S.5
  • 39
    • 20544474763 scopus 로고    scopus 로고
    • Differential stress reactivity in intact and ovariectomized prepubertal and adult female rats
    • Romeo, R.D., Lee, S.J., McEwen, B.S., Differential stress reactivity in intact and ovariectomized prepubertal and adult female rats. Neuroendocrinology 80 (2004), 387–393.
    • (2004) Neuroendocrinology , vol.80 , pp. 387-393
    • Romeo, R.D.1    Lee, S.J.2    McEwen, B.S.3
  • 41
    • 84856431319 scopus 로고    scopus 로고
    • Adolescent exposure to cannabis as a risk factor for psychiatric disorders
    • Rubino, T., Zamberletti, E., Parolaro, D., Adolescent exposure to cannabis as a risk factor for psychiatric disorders. J. Psychopharmacol. 26 (2012), 177–188.
    • (2012) J. Psychopharmacol. , vol.26 , pp. 177-188
    • Rubino, T.1    Zamberletti, E.2    Parolaro, D.3
  • 42
    • 84890167024 scopus 로고    scopus 로고
    • Results from the 2013 National Survey on Drug Use and Health: summary of national findings
    • Substance Abuse and Mental Health Services Administration Rockville, MD
    • SAMHSA, Results from the 2013 National Survey on Drug Use and Health: summary of national findings. 2014, Substance Abuse and Mental Health Services Administration, Rockville, MD.
    • (2014)
    • SAMHSA1
  • 43
    • 43749124806 scopus 로고    scopus 로고
    • Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure
    • Schneider, M., Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure. Addict. Biol. 13 (2008), 253–263.
    • (2008) Addict. Biol. , vol.13 , pp. 253-263
    • Schneider, M.1
  • 44
    • 26044438805 scopus 로고    scopus 로고
    • Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2
    • Schneider, M., Drews, E., Koch, M., Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2. Behav. Pharmacol. 16 (2005), 447–454.
    • (2005) Behav. Pharmacol. , vol.16 , pp. 447-454
    • Schneider, M.1    Drews, E.2    Koch, M.3
  • 45
    • 0642338928 scopus 로고    scopus 로고
    • Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats
    • Schneider, M., Koch, M., Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology 28 (2003), 1760–1769.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1760-1769
    • Schneider, M.1    Koch, M.2
  • 46
    • 84936945064 scopus 로고    scopus 로고
    • Sex-specific alterations in hippocampal cannabinoid 1 receptor expression following adolescent delta-9-tetrahydrocannabinol treatment in the rat
    • Silva, L., Harte-Hargrove, L., Izenwasser, S., Frank, A., Wade, D., Dow-Edwards, D., Sex-specific alterations in hippocampal cannabinoid 1 receptor expression following adolescent delta-9-tetrahydrocannabinol treatment in the rat. Neurosci. Lett. 602 (2015), 89–94.
    • (2015) Neurosci. Lett. , vol.602 , pp. 89-94
    • Silva, L.1    Harte-Hargrove, L.2    Izenwasser, S.3    Frank, A.4    Wade, D.5    Dow-Edwards, D.6
  • 47
    • 16544370834 scopus 로고    scopus 로고
    • The neural basis of puberty and adolescence
    • Sisk, C.L., Foster, D.L., The neural basis of puberty and adolescence. Nat. Neurosci. 7 (2004), 1040–1047.
    • (2004) Nat. Neurosci. , vol.7 , pp. 1040-1047
    • Sisk, C.L.1    Foster, D.L.2
  • 48
    • 0037402533 scopus 로고    scopus 로고
    • Prenatal cocaine and/or nicotine exposure produces depression and anxiety in aging rats
    • Sobrian, S.K., Marr, L., Ressman, K., Prenatal cocaine and/or nicotine exposure produces depression and anxiety in aging rats. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 27 (2003), 501–518.
    • (2003) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.27 , pp. 501-518
    • Sobrian, S.K.1    Marr, L.2    Ressman, K.3
  • 49
    • 0034056125 scopus 로고    scopus 로고
    • The adolescent brain and age-related behavioral manifestations
    • Spear, L.P., The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 24 (2000), 417–463.
    • (2000) Neurosci. Biobehav. Rev. , vol.24 , pp. 417-463
    • Spear, L.P.1
  • 51
    • 46649110318 scopus 로고    scopus 로고
    • Realistic expectations of prepulse inhibition in translational models for schizophrenia research
    • Swerdlow, N.R., Weber, M., Qu, Y., Light, G.A., Braff, D.L., Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology 199 (2008), 331–388.
    • (2008) Psychopharmacology , vol.199 , pp. 331-388
    • Swerdlow, N.R.1    Weber, M.2    Qu, Y.3    Light, G.A.4    Braff, D.L.5
  • 52
    • 0028959612 scopus 로고
    • Stress measurements in mice after transportation
    • Tuli, J.S., Smith, J.A., Morton, D.B., Stress measurements in mice after transportation. Lab. Anim. 29 (1995), 132–138.
    • (1995) Lab. Anim. , vol.29 , pp. 132-138
    • Tuli, J.S.1    Smith, J.A.2    Morton, D.B.3
  • 53
    • 0031787228 scopus 로고    scopus 로고
    • The influence of transportation stress on selected nutritional parameters to establish the necessary minimum period for adaptation in rat feeding studies
    • van Ruiven, R., Meijer, G.W., Wiersma, A., Baumans, V., van Zutphen, L.F., Ritskes-Hoitinga, J., The influence of transportation stress on selected nutritional parameters to establish the necessary minimum period for adaptation in rat feeding studies. Lab. Anim. 32 (1998), 446–456.
    • (1998) Lab. Anim. , vol.32 , pp. 446-456
    • van Ruiven, R.1    Meijer, G.W.2    Wiersma, A.3    Baumans, V.4    van Zutphen, L.F.5    Ritskes-Hoitinga, J.6
  • 54
    • 84886668177 scopus 로고    scopus 로고
    • Early maternal separation: a rodent model of depression and a prevailing human condition
    • Vetulani, J., Early maternal separation: a rodent model of depression and a prevailing human condition. Pharmacol. Rep. 65 (2013), 1451–1461.
    • (2013) Pharmacol. Rep. , vol.65 , pp. 1451-1461
    • Vetulani, J.1
  • 56
    • 0242669964 scopus 로고    scopus 로고
    • Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain
    • Wang, X., Dow-Edwards, D., Keller, E., Hurd, Y.L., Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain. Neuroscience 118 (2003), 681–694.
    • (2003) Neuroscience , vol.118 , pp. 681-694
    • Wang, X.1    Dow-Edwards, D.2    Keller, E.3    Hurd, Y.L.4
  • 57
    • 58249139081 scopus 로고    scopus 로고
    • Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment
    • Wegener, N., Koch, M., Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment. Brain Res. 1253 (2009), 81–91.
    • (2009) Brain Res. , vol.1253 , pp. 81-91
    • Wegener, N.1    Koch, M.2
  • 58
    • 0034749488 scopus 로고    scopus 로고
    • Alterations induced by gestational stress in brain morphology and behaviour of the offspring
    • Weinstock, M., Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog. Neurobiol. 65 (2001), 427–451.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 427-451
    • Weinstock, M.1
  • 59
    • 0037040043 scopus 로고    scopus 로고
    • The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats
    • Wenger, T., Gerendai, I., Fezza, F., Gonzalez, S., Bisogno, T., Fernandez-Ruiz, J., Di Marzo, V., The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats. Life Sci. 70 (2002), 1407–1414.
    • (2002) Life Sci. , vol.70 , pp. 1407-1414
    • Wenger, T.1    Gerendai, I.2    Fezza, F.3    Gonzalez, S.4    Bisogno, T.5    Fernandez-Ruiz, J.6    Di Marzo, V.7
  • 60
    • 0036245389 scopus 로고    scopus 로고
    • Metabolic mapping of the time-dependent effects of delta 9-tetrahydrocannabinol administration in the rat
    • Whitlow, C.T., Freedland, C.S., Porrino, L.J., Metabolic mapping of the time-dependent effects of delta 9-tetrahydrocannabinol administration in the rat. Psychopharmacology 161 (2002), 129–136.
    • (2002) Psychopharmacology , vol.161 , pp. 129-136
    • Whitlow, C.T.1    Freedland, C.S.2    Porrino, L.J.3
  • 61
    • 84902577055 scopus 로고    scopus 로고
    • Sex differences in delta(9)-tetrahydrocannabinol metabolism and in vivo pharmacology following acute and repeated dosing in adolescent rats
    • Wiley, J.L., Burston, J.J., Sex differences in delta(9)-tetrahydrocannabinol metabolism and in vivo pharmacology following acute and repeated dosing in adolescent rats. Neurosci. Lett. 576 (2014), 51–55.
    • (2014) Neurosci. Lett. , vol.576 , pp. 51-55
    • Wiley, J.L.1    Burston, J.J.2
  • 62
    • 58249083137 scopus 로고    scopus 로고
    • To breed or not to breed? Empirical evaluation of drug effects in adolescent rats
    • Wiley, J.L., Evans, R.L., To breed or not to breed? Empirical evaluation of drug effects in adolescent rats. Int. J. Dev. Neurosci. 27 (2009), 9–20.
    • (2009) Int. J. Dev. Neurosci. , vol.27 , pp. 9-20
    • Wiley, J.L.1    Evans, R.L.2
  • 63
    • 84857128131 scopus 로고    scopus 로고
    • Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats
    • Zamberletti, E., Prini, P., Speziali, S., Gabaglio, M., Solinas, M., Parolaro, D., Rubino, T., Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats. Neuroscience 204 (2012), 245–257.
    • (2012) Neuroscience , vol.204 , pp. 245-257
    • Zamberletti, E.1    Prini, P.2    Speziali, S.3    Gabaglio, M.4    Solinas, M.5    Parolaro, D.6    Rubino, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.