Effect of proton pump inhibitors and antibiotics on the gut microbiome of hospitalised older persons

Journal of Infection

Volumn 72, Issue 4, 2016, Pages 498-500

  O'Donoghue, Caoilfhionn ^a   Solomon, Katie ^b   Fenelon, Lynda ^c   Fitzpatrick, Fidelma ^d   Kyne, Lorraine ^a  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^d HEALTH PROTECTION SURVEILLANCE CENTRE   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PROTON PUMP INHIBITOR; STEROID; ANTIINFECTIVE AGENT;

ADULT; AGE; AGED; AGED HOSPITAL PATIENT; ANTIBIOTIC THERAPY; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DNA EXTRACTION; DRUG EFFECT; DRUG USE; FECES MICROFLORA; FRAIL ELDERLY; HUMAN; INDEPENDENCE; INFECTION RISK; INTESTINE FLORA; INTESTINE INFECTION; LENGTH OF STAY; LETTER; MALNUTRITION; MICROBIAL DIVERSITY; NONHUMAN; POLYPHARMACY; WEAKNESS; CLOSTRIDIUM INFECTIONS; COINFECTION; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; ISOLATION AND PURIFICATION; MALE; PEPTOCLOSTRIDIUM DIFFICILE;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COINFECTION; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HUMANS; MALE;

EID: 84960922715     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2016.01.015     Document Type: Letter

References (9)

1. Taori S.K., Wroe A., Hardie A., Gibb A.P., Poxton I.R. A prospective study of community-associated Clostridium difficile infections: the role of antibiotics and co-infections. J Infect 2014 Aug, 69(2):134-144.
2. Daniel A., Rapose A. The evaluation of Clostridium difficile infection (CDI) in a community hospital. J Infect Public Health 2015 Mar-Apr, 8(2):155-160.
3. Aseeri M., Schroeder T., Kramer J., Zackula R. Gastric acid suppression by proton pump inhibitors as a risk factor for Clostridium difficile-associated diarrhoea in hospitalized patients. Am J Gastroenterol 2008, 103(9):2308-2313.
4. Kwok C.S., Arthur A.K., Anibueze C.I., Singh S., Cavallazzi R., Loke Y.K. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am J Gastroenterol 2012 Jul, 107(7):1011-1019.
5. Wardwell L.H., Huttenhower C., Garrett W.S. Current concepts of the intestinal microbiota and the pathogenesis of infection. Curr Infect Dis Rep 2011 Feb, 13(1):28-34.
6. Perez-Cobas A.E., Gosalbes M.J., Friedrichs A., Knecht H., Artacho A., Eismann K., et al. Gut microbiota disturbance during antibiotic therapy: a multi-omic approach. Gut 2013 Nov, 62(11):1591-1601.
7. Buffie C.G., Pamer E.G. Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol 2013 Nov, 13(11):790-801.
8. Filion K.B., Chateau D., Targownik L.E., Gershon A., Durnad M., Tamim H., et al. Proton Pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut 2014 Apr, 63(4):552-558.
9. Novack L., Kogan S., Gimpelevich L., Howell M., Borer A., Kelly C.P., et al. Acid suppression therapy does not predispose to Clostridium difficile infection: the case of the potential bias. PLoS One 2014 Oct 24, 9(10):e110790.