Which dogs with appendicular osteosarcoma benefit most from chemotherapy after surgery? Results from an individual patient data meta-analysis

Preventive Veterinary Medicine

Volumn 125, Issue , 2016, Pages 116-125

  Schmidt, A F ^a,b,c,d   Groenwold, R H H ^a,b   Amsellem, P ^e   Bacon, N ^g   Klungel, O H ^a,b   Hoes, A W ^a   de Boer, A ^b   Kow, K ^g   Maritato, K ^f   Kirpensteijn, J ^h   Nielen, M ^c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^f MedVet Medical and Cancer Centers for Pets   (United States)

^g UNIVERSITY OF FLORIDA   (United States)

^h UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Bone tumor; Canine; Oncology; Personalized medicine

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; CARBOPLATIN; CISPLATIN; DOXORUBICIN;

ANIMAL; BONE NEOPLASMS; DOG; DOG DISEASES; META ANALYSIS; MORTALITY; MULTIVARIATE ANALYSIS; OSTEOSARCOMA; VETERINARY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE NEOPLASMS; CARBOPLATIN; CISPLATIN; DOG DISEASES; DOGS; DOXORUBICIN; MULTIVARIATE ANALYSIS; OSTEOSARCOMA;

EID: 84960810134     PISSN: 01675877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prevetmed.2015.10.016     Document Type: Article

References (45)

1. Altman D.G., Bland J.M. Missing data. BMJ 2007, 334:424.
2. Amsellem P.M., Selmic L.E., Wypij J.M., Bacon N.J., Culp W.T., Ehret N.P., Powers B.E., Stryhn H., Farese J.P. Appendicular osteosarcoma in small-breed dogs: 51 cases (1986-2011). J. Am. Vet. Med. Assoc. 2014.
3. Arbogast P.G., Kaltenbach L., Ding H., Ray W.A. Adjustment for multiple cardiovascular risk factors using a summary risk score. Epidemiology 2008, 19:30-37.
4. Bailey D., Erb H., Williams L., Ruslander D., Hauck M. Carboplatin and doxorubicin combination chemotherapy for the treatment of appendicular osteosarcoma in the dog. J. Vet. Intern. Med. 2003, 17:199-205.
5. Bates, D., Maechler, M., Bolker, B., 2012. lme4: Linear mixed-effects models using S4 classes.
6. Bland J.M., Altman D.G. Multiple significance tests: the Bonferroni method. BMJ 1995, 310:170.
7. Boerman I., Selvarajah G.T., Nielen M., Kirpensteijn J. Prognostic factors in canine appendicular osteosarcoma-a meta-analysis. BMC Vet. Res. 2012, 8:56.
8. Brodey R.S., Abt D.A. Results of surgical treatment in 65 dogs with osteosarcoma. J. Am. Vet. Med. Assoc. 1976, 168:1032-1035.
9. Burke J.F., Hayward R.A., Nelson J.P., Kent D.M. Using internally developed risk models to assess heterogeneity in treatment effects in clinical trials. Circ. Cardiovasc. Qual. Outcomes 2014, 7:163-169.
10. Carpenter J., Bithell J. Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians. Stat. Med. 2000, 19:1141-1164.
11. Chatfield C. Model uncertainty, data mining and statistical inference. J. R. Stat. Soc. Ser. A (Stat. Soc.) 1995, 158:419-466.
12. Chun R., Kurzman I.D., Couto C.G., Klausner J., Henry C., MacEwen E.G. Cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma: a pilot study. J. Vet. Intern. Med. 2000, 14:495-498.
13. Chun R., Garrett L.D., Henry C., Wall M., Smith A., Azene N.M. Toxicity and efficacy of cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma. J. Am. Anim. Hosp. Assoc. 2005, 41:382-387.
14. Cooley D.M., Waters D.J. Skeletal neoplasms of small dogs: a retrospective study and literature review. J. Am. Anim. Hosp. Assoc. 1997, 33:11-23.
15. Easterbrook P.J., Berlin J.A., Gopalan R., Matthews D.R. Publication bias in clinical research. Lancet 1991, 337:867-872.
16. Farooq V., van K.D., Steyerberg E.W., Meliga E., Vergouwe Y., Chieffo A., Kappetein A.P., Colombo A., Holmes D.R., Mack M., Feldman T., Morice M.C., Stahle E., Onuma Y., Morel M.A., Garcia-Garcia H.M., van Es G.A., Dawkins K.D., Mohr F.W., Serruys P.W. Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II. Lancet 2013, 381:639-650.
17. Harrell, Jr., F.E., Dupont, C., 2013. Hmisc: Harrell Miscellaneous R package.
18. Hernan M.A., Hernandez-Diaz S., Werler M.M., Mitchell A.A. Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiology. Am. J. Epidemiol. 2002, 155:176-184.
19. Kent D.M., Hayward R.A. Limitations of applying summary results of clinical trials to individual patients: the need for risk stratification. J. Am. Med. Assoc. 2007, 298:1209-1212.
20. Kirpensteijn J., Kik M., Rutteman G.R., Teske E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet. Pathol. 2002, 39:240-246.
21. Kow K., Thamm D.H., Terry J., Grunerud K., Bailey S.M., Withrow S.J., Lana S.E. Impact of telomerase status on canine osteosarcoma patients. J. Vet. Intern. Med. 2008, 22:1366-1372.
22. Little R.J.A., Rubin D.B. Statistical Analysis with Missing Data 2002, Wiley-Blackwell.
23. MacEwen E.G., Kurzman I.D. Canine osteosarcoma: amputation and chemoimmunotherapy. Vet. Clin. N. Am.: Small Anim. Pract. 1996, 26:123-133.
24. Marshall A., Altman D.G., Holder R.L., Royston P. Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines. BMC Med. Res. Methodol. 2009, 9:57.
25. McNeill C.J., Overley B., Shofer F.S., Kent M.S., Clifford C.A., Samluk M., Haney S., Van Winkle T.J., Sorenmo K.U. Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs. Vet. Comp. Oncol. 2007, 5:90-98.
26. Moons K.G., Kengne A.P., Woodward M., Royston P., Vergouwe Y., Altman D.G., Grobbee D.E. Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio) marker. Heart 2012, 98:683-690.
27. Norrdin R.W., Powers B.E., Torgersen J.L., Smith R.E., Withrow S.J. Characterization of osteosarcoma cells from two sibling large-breed dogs. Am. J. Vet. Res. 1989, 50:1971-1975.
28. R Development Core Team R: A Language and Environment for Statistical Computing 2013, Foundation for Statistical Computing, Vienna, Austria.
29. Ru G., Terracini B., Glickman L.T. Host related risk factors for canine osteosarcoma. Vet. J. 1998, 156:31-39.
30. Rubin D.B. Inference and missing data. Biometrika 1976, 63:581-592.
31. Schmidt A.F., Nielen M., Klungel O.H., Hoes A.W., de Boer A., Groenwold R.H., Kirpensteijn J. Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery: an individual patient data meta-analysis. Prev. Vet. Med. 2013, 112:414-422.
32. Sofroniou N., Hutcheson G.D. Confidence intervals for the predictions of logistic regression in the presence and absence of a variance- covariance matrix. Underst. Stat. 2002, 1:3-18.
33. Sottnik J.L., Rao S., Lafferty M.H., Thamm D.H., Morley P.S., Withrow S.J., Dow S.W. Association of blood monocyte and lymphocyte count and disease-free interval in dogs with osteosarcoma. J. Vet. Intern. Med. 2010, 24:1439-1444.
34. Spodnick G.J., Berg J., Rand W.M., Schelling S.H., Couto G., Harvey H.J., Henderson R.A., MacEwen G., Mauldin N., McCaw D.L. Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978-1988). J. Am. Vet. Med. Assoc. 1992, 200:995-999.
35. Steyerberg E.W. Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating 2009, Springer, New York.
36. Steyerberg E.W., Eijkemans M.J., Habbema J.D. Stepwise selection in small data sets: a simulation study of bias in logistic regression analysis. J. Clin. Epidemiol. 1999, 52:935-942.
37. Steyerberg E.W., Vickers A.J., Cook N.R., Gerds T., Gonen M., Obuchowski N., Pencina M.J., Kattan M.W. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology 2010, 21:128-138.
38. Steyerberg E.W., Schemper M., Harrell F.E. Logistic regression modeling and the number of events per variable: selection bias dominates. J. Clin. Epidemiol. 2011, 64:1464-1465.
39. Straw R.C., Withrow S.J. Limb-sparing surgery versus amputation for dogs with bone tumors. Vet. Clin. N. Am.: Small Anim. Pract. 1996, 26:135-143.
40. Straw R.C., Withrow S.J., Richter S.L., Powers B.E., Klein M.K., Postorino N.C., LaRue S.M., Ogilvie G.K., Vail D.M., Morrison W.B. Amputation and cisplatin for treatment of canine osteosarcoma. J. Vet. Intern. Med. 1991, 5:205-210.
41. Sun X., Briel M., Busse J.W., You J.J., Akl E.A., Mejza F., Bala M.M., Bassler D., Mertz D., az-Granados N., Vandvik P.O., Malaga G., Srinathan S.K., Dahm P., Johnston B.C., onso-Coello P., Hassouneh B., Truong J., Dattani N.D., Walter S.D., Heels-Ansdell D., Bhatnagar N., Altman D.G., Guyatt G.H. The influence of study characteristics on reporting of subgroup analyses in randomised controlled trials: systematic review. BMJ 2011, 342:d1569.
42. Vail D.M., MacEwen E.G., Kurzman I.D., Dubielzig R.R., Helfand S.C., Kisseberth W.C., London C.A., Obradovich J.E., Madewell B.R., Rodriguez C.O. Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: a randomized multi-institutional clinical trial. Clinical cancer research: an official journal of the 1995, 1:1165-1170.
43. Vail D.M., Kurzman I.D., Glawe P.C., O'Brien M.G., Chun R., Garrett L.D., Obradovich J.E., Fred R.M., Khanna C., Colbern G.T., Working P.K. STEALTH liposome-encapsulated cisplatin (SPI-77) versus carboplatin as adjuvant therapy for spontaneously arising osteosarcoma (OSA) in the dog: a randomized multicenter clinical trial. Cancer Chemother. Pharmacol. 2002, 50:131-136.
44. van Klaveren D., Vergouwe Y., Farooq V., Serruys P.W., Steyerberg E.W. Estimates of absolute treatment benefit for individual patients required careful modeling of statistical interactions. J. Clin. Epidemiol. 2015, 68:1366-1374.
45. Viechtbauer W. Conducting meta-analyses in R with the metafor package. J. Stat. Softw. 2010, 36:1-48.