Targeted Anticoagulation for Atrial Fibrillation Guided by Continuous Rhythm Assessment with an Insertable Cardiac Monitor: The Rhythm Evaluation for Anticoagulation with Continuous Monitoring (REACT.COM) Pilot Study

Journal of Cardiovascular Electrophysiology

Volumn 27, Issue 3, 2016, Pages 264-270

  Passman, Rod ^a   Leong Sit, Peter ^b   Andrei, Adin Cristian ^c   Huskin, Anna ^c   Tomson, Todd T ^c   Bernstein, Richard ^a   Ellis, Ethan ^d   Waks, Jonathan W ^d   Zimetbaum, Peter ^d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c NORTHWESTERN MEMORIAL HOSPITAL   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

anticoagulation; atrial fibrillation; implantable cardiac monitor; REVEAL; stroke; TIA

Indexed keywords

ANTICOAGULANT AGENT; APIXABAN; DABIGATRAN; RIVAROXABAN;

AGED; ANTICOAGULANT THERAPY; ARTICLE; ATRIAL FIBRILLATION; BLEEDING; CHADS2 SCORE; FEMALE; FOLLOW UP; HUMAN; IMPLANTABLE CARDIAC MONITOR; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; SINUS RHYTHM; TRANSIENT ISCHEMIC ATTACK; AMBULATORY ELECTROCARDIOGRAPHY; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; ELECTRODE IMPLANT; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PILOT STUDY; PROCEDURES; PROSPECTIVE STUDY;

ADMINISTRATION, ORAL; AGED; ANTICOAGULANTS; ATRIAL FIBRILLATION; DRUG DELIVERY SYSTEMS; ELECTROCARDIOGRAPHY, AMBULATORY; ELECTRODES, IMPLANTED; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES;

EID: 84960803779     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12864     Document Type: Article

References (26)

1. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW,: 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 2014; 64: e1-e76.
2. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L,; RE-LY Steering Committee and Investigators: Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-1151.
3. Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM,; ROCKET AF Investigators: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365: 883-891.
4. Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L,; ARISTOTLE Committees and Investigators: Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365: 981-992.
5. Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM,; ENGAGE AF-TIMI 48 Investigators: Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013; 369: 2093-2104.
6. Hart RG, Pearce LA, Aguilar MI,: Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007; 146: 857-867.
7. Strickberger SA, Ip J, Saksena S, Curry K, Bahnson TD, Ziegler PD,: Relationship between atrial tachyarrhythmias and symptoms. Heart Rhythm 2005; 2: 125-131.
8. Verma A, Champagne J, Sapp J, Essebag V, Novak P, Skanes A, Morillo CA, Khaykin Y, Birnie D,: Discerning the incidence of symptomatic and asymptomatic episodes of atrial fibrillation before and after catheter ablation (DISCERN AF): A prospective, multicenter study. JAMA 2013; 173: 149-156.
9. Sherman DG, Kim SG, Boop BS, Corley SD, Dimarco JP, Hart RG, Haywood LJ, Hoyte K, Kaufman ES, Kim MH, Nasco E, Waldo AL,; National Heart, Lung, and Blood Institute AFFIRM Investigators: Occurrence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) study. Arch Intern Med 2005; 165: 1185-1191.
10. Themistoclakis S, Corrado A, Marchlinski FE, Jais P, Zado E, Rossillo A, Di Biase L, Schweikert RA, Saliba WI, Horton R, Mohanty P, Patel D, Burkhardt DJ, Wazni OM, Bonso A, Callans DJ, Haissaguerre M, Raviele A, Natale A,: The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation. J Am Coll Cardiol 2010; 55: 735-743.
11. Riley MP, Zado E, Hutchinson MD, Lin D, Bala R, Garcia FC, Callans DJ, Cooper JM, Verdino RJ, Dixit S, Marchlinski FE,: Risk of stroke or transient ischemic attack after atrial fibrillation ablation with oral anticoagulant use guided by ECG monitoring and pulse assessment. J Cardiovasc Electrophysiol 2014; 25: 591-596.
12. Hindricks G, Pokushalov E, Urban L, Taborsky M, Kuck KH, Lebedev D, Rieger G, Pürerfellner H; XPECT Trial Investigators: Performance of a new leadless implantable cardiac monitor in detecting and quantifying atrial fibrillation: Results of the XPECT trial. Circ Arrhythm Electrophysiol 2010; 3: 141-147.
13. Martin DT, Bersohn MM, Waldo AL, Wathen MS, Choucair WK, Lip GY, Ip J, Holcomb R, Akar JG, Halperin JL,; IMPACT Investigators: Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. Eur Heart J 2015; 36: 1660-1668.
14. Kinsella JA, Tobin WO, Cogan N, McCabe DJ,: Interobserver agreement in ABCD scoring between non-stroke specialists and vascular neurologists following suspected TIA is only fair. J Neurol 2011; 258: 1001-1007.
15. Daoud EG, Glotzer TV, Wyse DG, Ezekowitz MD, Hilker C, Koehler J, Ziegler PD,; TRENDS Investigators: Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: A subgroup analysis of TRENDS. Heart Rhythm 2011; 8: 1416-1423.
16. Brambatti M, Connolly SJ, Gold MR, Morillo CA, Capucci A, Muto C, Lau CP, Van Gelder IC, Hohnloser SH, Carlson M, Fain E, Nakamya J, Mairesse GH, Halytska M, Deng WQ, Israel CW, Healey JS,; ASSERT Investigators: Temporal relationship between subclinical atrial fibrillation and embolic events. Circulation 2014; 129: 2094-2099.
17. Turakhia MP, Ziegler PD, Schmitt SK, Chang Y, Fan J, Than CT, Keung EK, Singer SE,: Atrial fibrillation burden and short-term risk of stroke: A case-crossover analysis of continuously recorded heart rhythm from cardiac electronic implanted devices. Circ Arrhythm Electrophysiol 2015; 8: 1040-1047.
18. Larsen JA, McPherson DD, Kadish AH, Goldberger JJ,: Course of intraatrial thrombi resolution using transesophageal echocardiography. Echocardiography 2003; 20: 121-128.
19. Nedios S, Koutalas E, Kornej J, Rolf S, Arya A, Sommer P, Husser D, Hindricks G, Bollmann A,: Cardiogenic stroke despite low CHA2DS2 -VASc score: Assessing stroke risk by left atrial appendage anatomy (ASK LAA). J Cardiovasc Electrophysiol 2015; 26: 915-921.
20. Cha MJ, Kim YD, Nam HS, Kim J, Lee DH, Heo JH,: Stroke mechanism in patients with nonvalvular atrial fibrillation according to the CHADS2 and CHA2 DS2 -VASc scores. Eur J Neurol 2012; 19: 473-479.
21. Azarbal F, Welles CC, Wong JM, Whooley MA, Schiller NB, Turakhia MP,: Association of CHADS2, CHA2DS2-VASc, and R2CHADS2 scores with left atrial dysfunction in patients with coronary heart disease (from the Heart and Soul study). Am J Cardiol 2014; 113: 1166-1172.
22. Guo Y, Lip GY, Apostolakis S,: Inflammation in atrial fibrillation. J Am Coll Cardiol 2012; 60: 2263-2270.
23. Healey JS, Connolly SJ, Gold MR, Israel CW, Van Gelder IC, Capucci A, Lau CP, Fain E, Yang S, Bailleul C, Morillo CA, Carlson M, Themeles E, Kaufman ES, Hohnloser SH,; ASSERT Investigators: Subclinical atrial fibrillation and the risk of stroke. N Engl J Med 2012; 366: 120-129.
24. Shanmugam N1, Boerdlein A, Proff J, Ong P, Valencia O, Maier SK, Bauer WR, Paul V, Sack S,: Detection of atrial high-rate events by continuous home monitoring: Clinical significance in the heart failure-cardiac resynchronization therapy population. Europace 2012; 14: 230-237.
25. Glotzer TV, Daoud EG, Wyse DG, Singer DE, Ezekowitz MD, Hilker C, Miller C, Qi D, Ziegler PD,: The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: The TRENDS study. Circ Arrhythm Electrophysiol 2009; 2: 474-480.
26. Capucci A1, Santini M, Padeletti L, Gulizia M, Botto G, Boriani G, Ricci R, Favale S, Zolezzi F, Di Belardino N, Molon G, Drago F, Villani GQ, Mazzini E, Vimercati M, Grammatico A,; Italian AT500 Registry Investigators: Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers. J Am Coll Cardiol 2005; 46: 1913-1920.