Interventions to improve the appropriate use of polypharmacy in older people: A Cochrane systematic review

BMJ Open

Volumn 5, Issue 12, 2015, Pages

  Cooper, Janine A ^a   Cadogan, Cathal A ^a   Patterson, Susan M ^b   Kerse, Ngaire ^c   Bradley, Marie C ^a   Ryan, Cristín ^a   Hughes, Carmel M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Belfast   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL PRACTICE; DECISION SUPPORT SYSTEM; ELDERLY CARE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INAPPROPRIATE PRESCRIBING; OUTCOME ASSESSMENT; PATIENT EDUCATION; PHARMACEUTICAL CARE; POLYPHARMACY; POTENTIALLY INAPPROPRIATE MEDICATION; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TIME SERIES ANALYSIS; AGED; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HOSPITALIZATION; MEDICATION COMPLIANCE; PRESCRIPTION; STANDARDS; STATISTICS AND NUMERICAL DATA;

AGED; DRUG PRESCRIPTIONS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HOSPITALIZATION; HUMANS; INAPPROPRIATE PRESCRIBING; MEDICATION ADHERENCE; POLYPHARMACY; POTENTIALLY INAPPROPRIATE MEDICATION LIST; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84960457090     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2015-009235     Document Type: Review

References (51)

1. World Health Organisation. Global health and ageing. Geneva: 2011. http://www.who.int/ageing/publications/global-health.pdf
2. Rechel B, Grundy E, Robine JM, et al. Ageing in the European Union. Lancet2013;381:1312-22.
3. Prescribing and Primary Care Health and Social Care. Prescriptions dispensed in the community. Statistics for 2003-13. England, 2014.
4. Slone Epidemiology Center. Patterns of medication use in the United States 2006: a report from the Slone Survey. 2007. http://www.bu. edu/slone/SloneSurvey/AnnualRpt/SloneSurveyWebReport2006.pdf
5. Stewart R. Polypharmacy in the elderly: a fait accompli? Drug Intell Clin Pharm 1990;24:321-3.
6. The King's Fund. Polypharmacy and medicines optimisation: making it safe and sound. London, 2013.
7. Rollason V, Vogt N. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. Drugs Aging 2003;20:817-32.
8. Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 2014;13:57-65.
9. Hajar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Psychiatry 2007;5:345-51.
10. Steinman M. Polypharmacy and the balance of medication benefits and risks. Am J Geriatr Pharmacother 2007;4:314-15.
11. Cahir C, Fahey T, Teeling M, et al. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol 2010;69:543-52.
12. Kaufmann CP, Tremp R, Hersberger KE, et al. Inappropriate prescribing: a systematic overview of published assessment tools. Eur J Clin Pharmacol 2014;70:1-11.
13. Kuijpers MAJ, van Marum RJ, Egberts ACG, et al. Relationship between polypharmacy and underprescribing. Br J Clin Pharmacol 2008;65:130-3.
14. Dimitrow MS, Airaksinen MSA, Kivelä S-L, et al. Comparison of prescribing criteria to evaluate the appropriateness of drug treatment in individuals aged 65 and older: a systematic review. J Am Geriatr Soc 2011;59:1521-30.
15. Hughes C, Cooper JA, Ryan C. Going beyond the numbers-a call to redefine polypharmacy. Br J Clin Pharmacol 2014;77:915-16.
16. Aronson JK. In defence of polypharmacy. Br J Clin Pharmacol 2004;57:119-20.
17. Bradley MC, Fahey T, Cahir C, et al. Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland Enhanced Prescribing Database. Eur J Clin Pharmacol 2012;68:1425-33.
18. Patterson S, Cadogan C, Kerse N, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev 2014;10:CD008165.
19. Ryan R, Santesso N, Lowe D, et al. Interventions to improve safe and effective medicines use by consumers: an overview of systematic reviews. Cochrane Database Syst Rev2014:4:CD007768.
20. Effective Practice and Organisation of Care group. EPOC Resour. Rev. authors. http://www.epoc.cochrane.org/en/handsearchers.html
21. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60:616-31.
22. Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol 1992;45:1045-51.
23. Higgins JPT, Altman DG, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
24. Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Chin J Evid Based Med 2009;9:8-11.
25. Gallagher P, O'Connor M, O'Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther 2011; 89:845-54.
26. Dalleur O, Boland B, Losseau C, et al. Reduction of potentially inappropriate medications using the STOPP criteria in frail older inpatients: a randomised controlled study. Drugs Aging 2014;31:291-8.
27. Bucci C, Jackevicius C, McFarlane K, et al. Pharmacist's contribution in a heart function clinic: patient perception and medication appropriateness. Can J Cardiol 2003; 19:391-6.
28. Crotty M, Rowett D, Spurling L, et al. Does the addition of a pharmacist transition coordinator improve evidence-based medication management and health outcomes in older adults moving from the hospital to a long-term care facility? Results of a randomized, controlled trial. Am J Geriatr Pharmacother 2004;2:257-64.
29. Hanlon JT, Weinberger M, Samsa GP, et al. A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med 1996;100:428-37.
30. Schmader KE, Hanlon JT, Pieper CF, et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004;116:394-401.
31. Spinewine A, Swine C, Dhillon S, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc 2007;55:658-65.
32. Taylor CT, Byrd DC, Krueger K. Improving primary care in rural Alabama with a pharmacy initiative. Am J Health Pharm 2003;60:1123-9.
33. Crotty M, Halbert J, Rowett D, et al. An outreach geriatric medication advisory service in residential aged care: a randomised controlled trial of case conferencing. Age Ageing 2004;33:612-17.
34. Tamblyn R, Huang A, Perreault R, et al. The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. CMAJ 2003;169:549-56.
35. Trygstad TK, Christensen DB, Wegner SE, et al. Analysis of the North Carolina Long-Term Care Polypharmacy Initiative: a multiple-cohort approach using propensity-score matching for both evaluation and targeting. Clin Ther 2009;31:2018-37.
36. Trygstad TK, Christensen D, Garmise J, et al. Pharmacist response to alerts generated from Medicaid pharmacy claims in a long-term care setting: results from the North Carolina polypharmacy initiative. J Manag Care Pharm 2005;11:575-83.
37. Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm 1990;47:533-43.
38. McLeod PJ, Huang AR, Tamblyn RM, et al. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. CMAJ 1997;156:385-91.
39. Cherubini A, Corsonello A, Lattanzio F. Underprescription of beneficial medicines in older people: causes, consequences and prevention. Drugs Aging 2012;29:463-75.
40. Cahir C, Moriarty F, Teljeur C, et al. Potentially inappropriate prescribing and vulnerability and hospitalization in older community-dwelling patients. Ann Pharmacother2014;48:1546-54.
41. Alldred DP, Raynor DK, Hughes C, et al. Interventions to optimise prescribing for older people in care homes. Cochrane Database Syst Rev 2013;2:CD009095.
42. Holland R, Desborough J, Goodyer L, et al. Does pharmacist-led medication review help to reduce hospital admissions and deaths in older people? A systematic review and meta-analysis. Br J Clin Pharmacol 2008;65:303-16.
43. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 2007;370:173-84.
44. Kaur S, Mitchell G, Vitetta L, et al. Interventions that can reduce inappropriate prescribing in the elderly: a systematic review. Drugs Aging 2009;26:1013-28.
45. Medical Research Council. Developing and evaluating complex interventions: new guidance. London, 2008.
46. Hoffmann TC, Glasziou PP, Boutron I, et al. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ 2014;348:g1687.
47. Michie S, Abraham C, Eccles MP, et al. Strengthening evaluation and implementation by specifying components of behaviour change interventions: a study protocol. Implement Sci 2011; 6:10.
48. Proctor EK, Powell BJ, McMillen JC. Implementation strategies: recommendations for specifying and reporting. Implement Sci 2013;8:139.
49. Bushardt RL, Massey EB, Simpson TW, et al. Polypharmacy: misleading, but manageable. Clin Interv Aging 2008;3:383-9.
50. Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther 2008;46:72-83.
51. Hill-Taylor B, Sketris I, Hayden J, et al. Application of the STOPP/START criteria: a systematic review of the prevalence of potentially inappropriate prescribing in older adults, and evidence of clinical, humanistic and economic impact. J Clin Pharm Ther 2013;38:360-72.