Pre-transplant phospholipase A2 receptor autoantibody concentration is associated with clinically significant recurrence of membranous nephropathy post-kidney transplantation

Clinical Transplantation

Volumn 30, Issue 4, 2016, Pages 461-469

  Gupta, Gaurav ^a   Fattah, Hasan ^a   Ayalon, Rivka ^b   Kidd, Jason ^a   Gehr, Todd ^a   Quintana, Luis F ^c   Kimball, Pamela ^a   Sadruddin, Salima ^a   Massey, H Davis ^a   Kumar, Dhiren ^a   King, Anne L ^a   Beck, Laurence H ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

Antiphospholipase A2 receptor autoantibody; Idiopathic membranous nephropathy; Kidney transplantation; Recurrent membranous nephropathy

Indexed keywords

AUTOANTIBODY; MYCOPHENOLATE MOFETIL; PHOSPHOLIPASE A2 RECEPTOR; PREDNISONE; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; B CELL LYMPHOMA; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MIDDLE AGED; PRIORITY JOURNAL; RECURRENT DISEASE; SENSITIVITY AND SPECIFICITY; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; FOLLOW UP; GLOMERULONEPHRITIS, MEMBRANOUS; GLOMERULUS FILTRATION RATE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGY; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TEST; LONGITUDINAL STUDY; POSTOPERATIVE COMPLICATION; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR;

AUTOANTIBODIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS, MEMBRANOUS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RECEPTORS, PHOSPHOLIPASE A2; RECURRENCE; RISK FACTORS; ROC CURVE;

EID: 84960456968     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/ctr.12711     Document Type: Article

References (24)

1. Ponticelli C, Glassock RJ. Posttransplant recurrence of primary glomerulonephritis. Clin J Am Soc Nephrol 2010: 5: 2363.
2. El-Zoghby ZM, Grande JP, Fraile MG, Norby SM, Fervenza FC, Cosio FG. Recurrent idiopathic membranous nephropathy: early diagnosis by protocol biopsies and treatment with anti-CD20 monoclonal antibodies. Am J Transplant 2009: 9: 2800.
3. Dabade TS, Grande JP, Norby SM, Fervenza FC, Cosio FG. Recurrent idiopathic membranous nephropathy after kidney transplantation: a surveillance biopsy study. Am J Transplant 2008: 8: 1318.
4. Golgert WA, Appel GB, Hariharan S. Recurrent glomerulonephritis after renal transplantation: an unsolved problem. Clin J Am Soc Nephrol 2008: 3: 800.
5. Brenchley PE, Poulton K, Morton M, Picton ML. The genetic contribution to recurrent autoimmune nephritis. Transplant Rev (Orlando) 2014: 28: 140.
6. Kanigicherla D, Gummadova J, McKenzie EA et al. Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy. Kidney Int 2013: 83: 940.
7. Coenen MJ, Hofstra JM, Debiec H et al. Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. J Am Soc Nephrol 2013: 24: 677.
8. Beck LH Jr, Bonegio RG, Lambeau G et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009: 361: 11.
9. Hofstra JM, Debiec H, Short CD et al. Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy. J Am Soc Nephrol 2012: 23: 1735.
10. Beck LH Jr, Fervenza FC, Beck DM et al. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol 2011: 22: 1543.
11. Hoxha E, Harendza S, Zahner G et al. An immunofluorescence test for phospholipase-A(2)-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transplant 2011: 26: 2526.
12. Bech AP, Hofstra JM, Brenchley PE, Wetzels JF. Association of anti-PLA(2)R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy. Clin J Am Soc Nephrol 2014: 9: 1386.
13. Stahl R, Hoxha E, Fechner K. PLA2R autoantibodies and recurrent membranous nephropathy after transplantation. N Engl J Med 2010: 363: 496.
14. Debiec H, Martin L, Jouanneau C et al. Autoantibodies specific for the phospholipase A2 receptor in recurrent and de novo membranous nephropathy. Am J Transplant 2011: 11: 2144.
15. Seitz-Polski B, Payre C, Ambrosetti D et al. Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients. Nephrol Dial Transplant 2014: 29: 2334.
16. Troyanov S, Wall CA, Miller JA, Scholey JW, Cattran DC, Toronto Glomerulonephritis Registry Group. Idiopathic membranous nephropathy: definition and relevance of a partial remission. Kidney Int 2004: 66: 1199.
17. Dahnrich C, Komorowski L, Probst C et al. Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy. Clin Chim Acta 2013: 421: 213.
18. Kattah A, Ayalon R, Beck LH Jr et al. Anti-phospholipase A receptor antibodies in recurrent membranous nephropathy. Am J Transplant 2015: 15: 1349.
19. Quintana LF, Blasco M, Seras M et al. Antiphospholipase A2 receptor antibody levels predict the risk of posttransplantation recurrence of membranous nephropathy. Transplantation 2015: 99: 1709.
20. van de Logt AE, Hofstra JM, Wetzels JF. Serum anti-PLA2R antibodies can be initially absent in idiopathic membranous nephropathy: seroconversion after prolonged follow-up. Kidney Int 2015: 87: 1263.
21. Stanescu HC, Arcos-Burgos M, Medlar A et al. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med 2011: 364: 616.
22. Tomas NM, Beck LH Jr, Meyer-Schwesinger C et al. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med 2014: 371: 2277.
23. Ponticelli C, Glassock RJ. De novo membranous nephropathy (MN) in kidney allografts. A peculiar form of alloimmune disease?. Transpl Int 2012: 25: 1205.
24. Lien YH, Lai LW. Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis. Nat Rev Nephrol 2011: 7: 85.