-
1
-
-
65349150503
-
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
-
Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol. 2009;174(4):1149-1153.
-
(2009)
Am J Pathol
, vol.174
, Issue.4
, pp. 1149-1153
-
-
Watanabe, T.1
Nobusawa, S.2
Kleihues, P.3
Ohgaki, H.4
-
2
-
-
84892373020
-
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
-
Johnson BE, Mazor T, Hong C, et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014;343(6167):189-193.
-
(2014)
Science
, vol.343
, Issue.6167
, pp. 189-193
-
-
Johnson, B.E.1
Mazor, T.2
Hong, C.3
-
3
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen P, Lee S, Duncan CG, et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012;483(7390):485-U144.
-
(2012)
Nature
, vol.483
, Issue.7390
, pp. 485-U144
-
-
Koivunen, P.1
Lee, S.2
Duncan, C.G.3
-
4
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012; 483(7390):479-483.
-
(2012)
Nature
, vol.483
, Issue.7390
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
-
5
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010;17(5):510-522.
-
(2010)
Cancer Cell
, vol.17
, Issue.5
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
6
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013;340(6132):626-630.
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
-
7
-
-
84907980918
-
Clinical safety and activity in a phase i trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies [abstract]
-
Apr 5-9; San Diego, CA, Philadelphia (PA): AACR
-
Stein E, Tallman M, Pollyea DA, et al. Clinical safety and activity in a phase I trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research, 2014 Apr 5-9; San Diego, CA, Philadelphia (PA): AACR;
-
(2014)
Proceedings of the 105th Annual Meeting of the American Association for Cancer Research
-
-
Stein, E.1
Tallman, M.2
Pollyea, D.A.3
-
8
-
-
85032653564
-
-
Cancer Res. 2014;74(Suppl 19):103.
-
(2014)
Cancer Res.
, vol.74
, pp. 103
-
-
-
9
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274): 739-744.
-
(2009)
Nature
, vol.462
, Issue.7274
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
10
-
-
84875496294
-
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
Losman JA, Looper RE, Koivunen P, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
-
(2013)
Science
, vol.339
, Issue.6127
, pp. 1621-1625
-
-
Losman, J.A.1
Looper, R.E.2
Koivunen, P.3
-
11
-
-
84859554794
-
2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size
-
Capper D, Simon M, Langhans CD, et al. 2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size. Int J Cancer. 2012;131(3):766-768.
-
(2012)
Int J Cancer
, vol.131
, Issue.3
, pp. 766-768
-
-
Capper, D.1
Simon, M.2
Langhans, C.D.3
-
12
-
-
84855710482
-
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
-
Andronesi OC, Kim GS, Gerstner E, et al. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med. 2012;4(116):1-22.
-
(2012)
Sci Transl Med
, vol.4
, Issue.116
, pp. 1-22
-
-
Andronesi, O.C.1
Kim, G.S.2
Gerstner, E.3
-
13
-
-
84862776826
-
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
-
Choi C, Ganji SK, DeBerardinis RJ, et al. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med. 2012;18(4):624-629.
-
(2012)
Nat Med
, vol.18
, Issue.4
, pp. 624-629
-
-
Choi, C.1
Ganji, S.K.2
DeBerardinis, R.J.3
-
14
-
-
19944421821
-
Spectral analysis of multichannel MRS data
-
Sandgren N, Stoica P, Frigo FJ, Selen Y. Spectral analysis of multichannel MRS data. J Magn Reson. 2005;175(1):79-91.
-
(2005)
J Magn Reson
, vol.175
, Issue.1
, pp. 79-91
-
-
Sandgren, N.1
Stoica, P.2
Frigo, F.J.3
Selen, Y.4
-
15
-
-
0142094100
-
1H and13C NMR study of 2-hydroxyglutaric acid and its lactone
-
Bal D, Gryff-Keller A. 1H and13C NMR study of 2-hydroxyglutaric acid and its lactone. Magn Reson Chem. 2002;40(8):533-536.
-
(2002)
Magn Reson Chem
, vol.40
, Issue.8
, pp. 533-536
-
-
Bal, D.1
Gryff-Keller, A.2
-
16
-
-
0034099574
-
Proton NMR chemical shifts and coupling constants for brain metabolites
-
Govindaraju V, Young K, Maudsley A. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000;13:129-153.
-
(2000)
NMR Biomed
, vol.13
, pp. 129-153
-
-
Govindaraju, V.1
Young, K.2
Maudsley, A.3
-
17
-
-
45949089131
-
Optimal phased-array combination for spectroscopy
-
Bydder M, Hamilton G, Yokoo T, Sirlin CB. Optimal phased-array combination for spectroscopy. Magn Reson Imaging. 2008;26(6): 847-850.
-
(2008)
Magn Reson Imaging
, vol.26
, Issue.6
, pp. 847-850
-
-
Bydder, M.1
Hamilton, G.2
Yokoo, T.3
Sirlin, C.B.4
-
18
-
-
0031425055
-
Theory and application of array coils in MR spectroscopy
-
Wright S, Wald L. Theory and application of array coils in MR spectroscopy. NMR Biomed. 1997;10:394-410.
-
(1997)
NMR Biomed
, vol.10
, pp. 394-410
-
-
Wright, S.1
Wald, L.2
-
19
-
-
0011600888
-
Improvement of the analytical quality of MR spectroscopy data by frequency corrected averaging [abstract]
-
Schubert FSF, Elster C, Link A, et al. Improvement of the analytical quality of MR spectroscopy data by frequency corrected averaging [abstract]. Magn Reson Mat Physiol Biol Med. 2000;11(Suppl. 1): 189.
-
(2000)
Magn Reson Mat Physiol Biol Med
, vol.11
, pp. 189
-
-
Schubert, F.S.F.1
Elster, C.2
Link, A.3
-
20
-
-
0033040399
-
Sources of variability in the response of coupled spins to the PRESS sequence and their potential impact on metabolite quantification
-
Thompson R, Allen P. Sources of variability in the response of coupled spins to the PRESS sequence and their potential impact on metabolite quantification. Magn Reson Med. 1999;41(6): 1162-1169.
-
(1999)
Magn Reson Med
, vol.41
, Issue.6
, pp. 1162-1169
-
-
Thompson, R.1
Allen, P.2
-
21
-
-
84907053684
-
Advanced magnetic resonance imaging of the physical processes in human glioblastoma
-
Kalpathy-Cramer J, Gerstner ER, Emblem KE, Andronesi OC, Rosen B. Advanced magnetic resonance imaging of the physical processes in human glioblastoma. Cancer Res. 2014;74(17): 4622-4637.
-
(2014)
Cancer Res
, vol.74
, Issue.17
, pp. 4622-4637
-
-
Kalpathy-Cramer, J.1
Gerstner, E.R.2
Emblem, K.E.3
Andronesi, O.C.4
Rosen, B.5
-
22
-
-
0023636904
-
Spatial localization in NMR spectroscopy in vivo
-
Bottonley P. Spatial localization in NMR spectroscopy in vivo. Ann N Y Acad Sci. 1987;508:333-348.
-
(1987)
Ann N y Acad Sci
, vol.508
, pp. 333-348
-
-
Bottonley, P.1
-
23
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765-773.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
24
-
-
84932628860
-
Comprehensive, integrative genomic analysis of diffuse lower-Grade gliomas
-
Cancer Genome Atlas Research N, Brat DJ, Verhaak RG, Aldape KD, et al. Comprehensive, integrative genomic analysis of diffuse lower-Grade gliomas. N Engl J Med. 2015;372(26): 2481-2498.
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2481-2498
-
-
Cancer Genome Atlas Research Brat N, D.J.1
Verhaak, R.G.2
Aldape, K.D.3
-
25
-
-
84932649039
-
Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors
-
Eckel-Passow JE, Lachance DH, Molinaro AM, et al. Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med. 2015;372(26):2499-2508.
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2499-2508
-
-
Eckel-Passow, J.E.1
Lachance, D.H.2
Molinaro, A.M.3
-
27
-
-
34247503858
-
Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults
-
Al-Okaili RN, Krejza J,Wang SM,Woo JH, Melhem ER. Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults. Radiographics. 2006;26:S173-SU84.
-
(2006)
Radiographics
, vol.26
, pp. S173-SU84
-
-
Al-Okaili, R.N.1
Krejza, J.2
Wang, S.M.3
Woo, J.H.4
Melhem, E.R.5
-
29
-
-
84879374380
-
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
-
DiNardo CD, Propert KJ, Loren AW, et al. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood. 2013;121(24): 4917-4924.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4917-4924
-
-
DiNardo, C.D.1
Propert, K.J.2
Loren, A.W.3
-
30
-
-
84870557152
-
Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response
-
Fathi AT, Sadrzadeh H, Borger DR, et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. Blood. 2012;120(23):4649-4652.
-
(2012)
Blood
, vol.120
, Issue.23
, pp. 4649-4652
-
-
Fathi, A.T.1
Sadrzadeh, H.2
Borger, D.R.3
-
31
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross S, Cairns RA, Minden MD, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med. 2010;207(2):339-344.
-
(2010)
J Exp Med
, vol.207
, Issue.2
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
|