Identification of a novel inhibitor of isocitrate lyase as a potent antitubercular agent against both active and non-replicating Mycobacterium tuberculosis

Tuberculosis

Volumn 97, Issue , 2016, Pages 38-46

  Liu, Yishuang ^a   Zhou, Shuang ^b   Deng, Qi ^a   Li, Xinghua ^a   Meng, Jianzhou ^a   Guan, Yan ^a   Li, Chuanyou ^c   Xiao, Chunling ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Antitubercular agent; Inhibitor; Isocitrate lyase; Latent; Mycobacterium tuberculosis

Indexed keywords

AMINO ACID; ENZYME INHIBITOR; IMBI 3; ISOCITRATE LYASE; ISONIAZID; RECOMBINANT ENZYME; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PROTEIN BINDING;

ANIMAL CELL; ANTITUBERCULAR ACTIVITY; ARTICLE; BACTERIAL STRAIN; CIRCULAR DICHROISM; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; EXTENSIVELY DRUG RESISTANT TUBERCULOSIS; FUORESCENCE QUENCHING ASSAY; HIGH THROUGHPUT SCREENING; IC50; IN VITRO STUDY; INHIBITION CONSTANT; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOUSE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TUBERCULOSIS; ANTAGONISTS AND INHIBITORS; ATYPICAL MYCOBACTERIOSIS; BINDING SITE; CELL LINE; CHEMISTRY; COMBINATION DRUG THERAPY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HUMAN; KINETICS; LATENT TUBERCULOSIS; METABOLISM; MICROBIOLOGY; PROTEIN CONFORMATION; SPECTROFLUOROMETRY;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CELL LINE; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG THERAPY, COMBINATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ISOCITRATE LYASE; KINETICS; LATENT TUBERCULOSIS; MACROPHAGES; MOLECULAR DOCKING SIMULATION; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE;

EID: 84960329240     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2015.12.003     Document Type: Article

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