-
1
-
-
79960299888
-
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
-
Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17:4550-4557.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 4550-4557
-
-
Rosenberg, S.A.1
Yang, J.C.2
Sherry, R.M.3
-
2
-
-
70149114880
-
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
-
Johnson LA, Morgan RA, Dudley ME, et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood. 2009;114:535-546.
-
(2009)
Blood.
, vol.114
, pp. 535-546
-
-
Johnson, L.A.1
Morgan, R.A.2
Dudley, M.E.3
-
3
-
-
84923118622
-
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
-
Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol. 2015;33:540-549.
-
(2015)
J Clin Oncol.
, vol.33
, pp. 540-549
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Kassim, S.H.3
-
4
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
Morgan RA, Dudley ME, Wunderlich JR, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006;314:126-129.
-
(2006)
Science.
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
-
5
-
-
79952187823
-
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
-
Parkhurst MR, Yang JC, Langan RC, et al. T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol Ther. 2011;19:620-626.
-
(2011)
Mol Ther.
, vol.19
, pp. 620-626
-
-
Parkhurst, M.R.1
Yang, J.C.2
Langan, R.C.3
-
6
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
Brentjens RJ, Riviere I, Park JH, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 2011;118:4817-4828.
-
(2011)
Blood.
, vol.118
, pp. 4817-4828
-
-
Brentjens, R.J.1
Riviere, I.2
Park, J.H.3
-
7
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
Jensen MC, Popplewell L, Cooper LJ, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant. 2010;16:1245-1256.
-
(2010)
Biol Blood Marrow Transplant.
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
-
8
-
-
84897557033
-
Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition
-
Riddell SR, Sommermeyer D, Berger C, et al. Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition. Cancer J. 2014;20:141-144.
-
(2014)
Cancer J.
, vol.20
, pp. 141-144
-
-
Riddell, S.R.1
Sommermeyer, D.2
Berger, C.3
-
9
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18:843-851.
-
(2010)
Mol Ther.
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
-
10
-
-
84873991752
-
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
-
Morgan RA, Chinnasamy N, Abate-Daga D, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother. 2013;36:133-151.
-
(2013)
J Immunother.
, vol.36
, pp. 133-151
-
-
Morgan, R.A.1
Chinnasamy, N.2
Abate-Daga, D.3
-
11
-
-
0035257952
-
Wilms' tumor gene WT1: Its oncogenic function and clinical application
-
Sugiyama H. Wilms' tumor gene WT1: its oncogenic function and clinical application. Int J Hematol. 2001;73:177-187.
-
(2001)
Int J Hematol.
, vol.73
, pp. 177-187
-
-
Sugiyama, H.1
-
12
-
-
77952566271
-
WT1 (Wilms' tumor gene 1): Biology and cancer immunotherapy
-
Sugiyama H. WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy. Jpn J Clin Oncol. 2010;40:377-387.
-
(2010)
Jpn J Clin Oncol.
, vol.40
, pp. 377-387
-
-
Sugiyama, H.1
-
13
-
-
0031010990
-
Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis
-
Baird PN, Simmons PJ. Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis. Exp Hematol. 1997;25:312-320.
-
(1997)
Exp Hematol.
, vol.25
, pp. 312-320
-
-
Baird, P.N.1
Simmons, P.J.2
-
14
-
-
0026016308
-
Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development
-
Buckler AJ, Pelletier J, Haber DA, et al. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol. 1991;11: 1707-1712.
-
(1991)
Mol Cell Biol.
, vol.11
, pp. 1707-1712
-
-
Buckler, A.J.1
Pelletier, J.2
Haber, D.A.3
-
15
-
-
0034112824
-
Human cytotoxic Tlymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product
-
Oka Y, Elisseeva OA, Tsuboi A, et al. Human cytotoxic Tlymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product. Immunogenetics. 2000;51:99-107.
-
(2000)
Immunogenetics.
, vol.51
, pp. 99-107
-
-
Oka, Y.1
Elisseeva, O.A.2
Tsuboi, A.3
-
16
-
-
0033966369
-
HLA class I-restricted lysis of leukemia cells by a CD8(+) cytotoxic T-lymphocyte clone specific for WT1 peptide
-
Ohminami H, Yasukawa M, Fujita S. HLA class I-restricted lysis of leukemia cells by a CD8(+) cytotoxic T-lymphocyte clone specific for WT1 peptide. Blood. 2000;95:286-293.
-
(2000)
Blood.
, vol.95
, pp. 286-293
-
-
Ohminami, H.1
Yasukawa, M.2
Fujita, S.3
-
17
-
-
0037111734
-
Two distinct HLAA0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
-
Bellantuono I, Gao L, Parry S, et al. Two distinct HLAA0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL. Blood. 2002;100:3835-3837.
-
(2002)
Blood.
, vol.100
, pp. 3835-3837
-
-
Bellantuono, I.1
Gao, L.2
Parry, S.3
-
18
-
-
33846253186
-
Identification of a highly immunogenic HLA-A∗01-binding T cell epitope of WT1
-
Asemissen AM, Keilholz U, Tenzer S, et al. Identification of a highly immunogenic HLA-A∗01-binding T cell epitope of WT1. Clin Cancer Res. 2006;12:7476-7482.
-
(2006)
Clin Cancer Res.
, vol.12
, pp. 7476-7482
-
-
Asemissen, A.M.1
Keilholz, U.2
Tenzer, S.3
-
19
-
-
23744460167
-
Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner
-
Guo Y, Niiya H, Azuma T, et al. Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner. Blood. 2005;106:1415-1418.
-
(2005)
Blood.
, vol.106
, pp. 1415-1418
-
-
Guo, Y.1
Niiya, H.2
Azuma, T.3
-
20
-
-
34247174293
-
Identification and characterization of a WT1 (Wilms Tumor Gene) proteinderived HLA-DRB1∗0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes
-
Fujiki F, Oka Y, Tsuboi A, et al. Identification and characterization of a WT1 (Wilms Tumor Gene) proteinderived HLA-DRB1∗0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes. J Immunother. 2007;30:282-293.
-
(2007)
J Immunother.
, vol.30
, pp. 282-293
-
-
Fujiki, F.1
Oka, Y.2
Tsuboi, A.3
-
21
-
-
84865403847
-
Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias
-
Doubrovina E, Carpenter T, Pankov D, et al. Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias. Blood. 2012;120:1633-1646.
-
(2012)
Blood.
, vol.120
, pp. 1633-1646
-
-
Doubrovina, E.1
Carpenter, T.2
Pankov, D.3
-
22
-
-
84857401848
-
Active specific immunotherapy targeting the Wilms' tumor protein 1 (WT1) for patients with hematological malignancies and solid tumors: Lessons from early clinical trials
-
Van DA, Berneman ZN, Van Tendeloo VF. Active specific immunotherapy targeting the Wilms' tumor protein 1 (WT1) for patients with hematological malignancies and solid tumors: lessons from early clinical trials. Oncologist. 2012;17: 250-259.
-
(2012)
Oncologist.
, vol.17
, pp. 250-259
-
-
Van, D.A.1
Berneman, Z.N.2
Van Tendeloo, V.F.3
-
23
-
-
84875975917
-
Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients
-
Chapuis AG, Ragnarsson GB, Nguyen HN, et al. Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients. Sci Transl Med. 2013;5:174ra27.
-
(2013)
Sci Transl Med.
, vol.5
, pp. 174ra27
-
-
Chapuis, A.G.1
Ragnarsson, G.B.2
Nguyen, H.N.3
-
24
-
-
0034176750
-
Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1
-
Gao L, Bellantuono I, Elsasser A, et al. Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood. 2000;95:2198-2203.
-
(2000)
Blood.
, vol.95
, pp. 2198-2203
-
-
Gao, L.1
Bellantuono, I.2
Elsasser, A.3
-
25
-
-
84891528521
-
Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury
-
Asai H, Fujiwara H, Kitazawa S, et al. Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury. J Hematol Oncol. 2014;7:3.
-
(2014)
J Hematol Oncol.
, vol.7
, pp. 3
-
-
Asai, H.1
Fujiwara, H.2
Kitazawa, S.3
-
26
-
-
30744465074
-
Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation
-
Chapiro J, Claverol S, Piette F, et al. Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation. J Immunol. 2006;176:1053-1061.
-
(2006)
J Immunol.
, vol.176
, pp. 1053-1061
-
-
Chapiro, J.1
Claverol, S.2
Piette, F.3
-
27
-
-
33749005425
-
Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability
-
Cohen CJ, Zhao Y, Zheng Z, et al. Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res. 2006;66:8878-8886.
-
(2006)
Cancer Res.
, vol.66
, pp. 8878-8886
-
-
Cohen, C.J.1
Zhao, Y.2
Zheng, Z.3
-
28
-
-
84866534644
-
Analysis of the processing of seven human tumor antigens by intermediate proteasomes
-
Guillaume B, Stroobant V, Bousquet-Dubouch MP, et al. Analysis of the processing of seven human tumor antigens by intermediate proteasomes. J Immunol. 2012;189:3538-3547.
-
(2012)
J Immunol.
, vol.189
, pp. 3538-3547
-
-
Guillaume, B.1
Stroobant, V.2
Bousquet-Dubouch, M.P.3
-
29
-
-
84875258216
-
The immunoproteasome in antigen processing and other immunological functions
-
Basler M, Kirk CJ, Groettrup M. The immunoproteasome in antigen processing and other immunological functions. Curr Opin Immunol. 2013;25:74-80.
-
(2013)
Curr Opin Immunol.
, vol.25
, pp. 74-80
-
-
Basler, M.1
Kirk, C.J.2
Groettrup, M.3
-
30
-
-
84892711807
-
Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy
-
Turcotte S, Gros A, Tran E, et al. Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy. Clin Cancer Res. 2014;20:331-343.
-
(2014)
Clin Cancer Res.
, vol.20
, pp. 331-343
-
-
Turcotte, S.1
Gros, A.2
Tran, E.3
-
31
-
-
69049089548
-
The prioritization of cancer antigens: A national cancer institute pilot project for the acceleration of translational research
-
Cheever MA, Allison JP, Ferris AS, et al. The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res. 2009;15:5323-5337.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 5323-5337
-
-
Cheever, M.A.1
Allison, J.P.2
Ferris, A.S.3
-
32
-
-
84920390437
-
Survivin-specific T cell receptor targets tumor but not T cells
-
Arber C, Feng X, Abhyankar H, et al. Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest. 2015; 125:157-168.
-
(2015)
J Clin Invest.
, vol.125
, pp. 157-168
-
-
Arber, C.1
Feng, X.2
Abhyankar, H.3
-
33
-
-
84896398249
-
A novel murine T-cell receptor targeting NY-ESO-1
-
Rosati SF, Parkhurst MR, Hong Y, et al. A novel murine T-cell receptor targeting NY-ESO-1. J Immunother. 2014;37: 135-146.
-
(2014)
J Immunother.
, vol.37
, pp. 135-146
-
-
Rosati, S.F.1
Parkhurst, M.R.2
Hong, Y.3
-
34
-
-
0032212445
-
Identification of a shared HLA-A∗0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2)
-
Parkhurst MR, Fitzgerald EB, Southwood S, et al. Identification of a shared HLA-A∗0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2). Cancer Res. 1998;58:4895-4901.
-
(1998)
Cancer Res.
, vol.58
, pp. 4895-4901
-
-
Parkhurst, M.R.1
Fitzgerald, E.B.2
Southwood, S.3
-
35
-
-
38449094082
-
Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells
-
Thomas S, Xue SA, Cesco-Gaspere M, et al. Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells. J Immunol. 2007;179:5803-5810.
-
(2007)
J Immunol.
, vol.179
, pp. 5803-5810
-
-
Thomas, S.1
Xue, S.A.2
Cesco-Gaspere, M.3
-
36
-
-
84862681257
-
The immunoproteasome as a target in hematologic malignancies
-
Kuhn DJ, Orlowski RZ. The immunoproteasome as a target in hematologic malignancies. Semin Hematol. 2012;49: 258-262.
-
(2012)
Semin Hematol.
, vol.49
, pp. 258-262
-
-
Kuhn, D.J.1
Orlowski, R.Z.2
-
37
-
-
0028000102
-
Role of proteasomes modified by interferongamma in antigen processing
-
Tanaka K. Role of proteasomes modified by interferongamma in antigen processing. J Leukoc Biol. 1994;56:571-575.
-
(1994)
J Leukoc Biol.
, vol.56
, pp. 571-575
-
-
Tanaka, K.1
-
38
-
-
27644566777
-
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells
-
Xue SA, Gao L, Hart D, et al. Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells. Blood. 2005;106:3062-3067.
-
(2005)
Blood.
, vol.106
, pp. 3062-3067
-
-
Xue, S.A.1
Gao, L.2
Hart, D.3
-
39
-
-
84946494672
-
Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential
-
Zhao Q, Ahmed M, Tassev DV, et al. Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential. Leukemia. 2015;29: 2238-2247.
-
(2015)
Leukemia.
, vol.29
, pp. 2238-2247
-
-
Zhao, Q.1
Ahmed, M.2
Tassev, D.V.3
-
40
-
-
84890192723
-
Re-adapting T cells for cancer therapy: From mouse models to clinical trials
-
Stromnes IM, Schmitt TM, Chapuis AG, et al. Re-adapting T cells for cancer therapy: from mouse models to clinical trials. Immunol Rev. 2014;257:145-164.
-
(2014)
Immunol Rev.
, vol.257
, pp. 145-164
-
-
Stromnes, I.M.1
Schmitt, T.M.2
Chapuis, A.G.3
-
41
-
-
8444248183
-
In vitro stimulation with WT1 peptide-loaded Epstein-Barr viruspositive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity
-
Doubrovina ES, Doubrovin MM, Lee S, et al. In vitro stimulation with WT1 peptide-loaded Epstein-Barr viruspositive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity. Clin Cancer Res. 2004;10:7207-7219.
-
(2004)
Clin Cancer Res.
, vol.10
, pp. 7207-7219
-
-
Doubrovina, E.S.1
Doubrovin, M.M.2
Lee, S.3
-
42
-
-
84923220418
-
Cardiac endothelial cells express Wilms' tumor-1: Wt1 expression in the developing, adult and infarcted heart
-
Duim SN, Kurakula K, Goumans MJ, et al. Cardiac endothelial cells express Wilms' tumor-1: Wt1 expression in the developing, adult and infarcted heart. J Mol Cell Cardiol. 2015;81:127-135.
-
(2015)
J Mol Cell Cardiol.
, vol.81
, pp. 127-135
-
-
Duim, S.N.1
Kurakula, K.2
Goumans, M.J.3
|