Expanded findings from a randomized controlled trial of preconception low-dose aspirin and pregnancy loss

Human Reproduction

Volumn 31, Issue 3, 2016, Pages 657-665

  Mumford, Sunni L ^a   Silver, Robert M ^b   Sjaarda, Lindsey A ^a   Wactawski Wende, Jean ^c   Townsend, Janet M ^d   Lynch, Anne M ^e   Galai, Noya ^f   Lesher, Laurie L ^b   Faraggi, David ^f   Perkins, Neil J ^a   Schliep, Karen C ^a   Zarek, Shvetha M ^a   Schisterman, Enrique F ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d PA Professor of Surgery Department of Clinical Sciences The Geisinger Commonwealth Medical College Scranton   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF HAIFA   (Israel)

Author keywords

conception; fertility; live birth; low dose aspirin; pregnancy loss

Indexed keywords

ACETYLSALICYLIC ACID; CHORIONIC GONADOTROPIN; FOLIC ACID; PLACEBO;

ADULT; ANEUPLOIDY; ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; EMBRYO; FEMALE; FEMALE FERTILITY; FETUS; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HORMONE URINE LEVEL; HUMAN; INTENTION TO TREAT ANALYSIS; KARYOTYPING; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MATERNAL CARE; MENSTRUAL CYCLE; MICROARRAY ANALYSIS; MULTICENTER STUDY; NIDATION; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT ABORTION; THERAPY EFFECT; UNITED STATES; ABORTION, SPONTANEOUS; ADOLESCENT; CLINICAL TRIAL; PREGNANCY; PREGNANCY OUTCOME; REGRESSION ANALYSIS;

ABORTION, SPONTANEOUS; ADOLESCENT; ADULT; ASPIRIN; DOUBLE-BLIND METHOD; FEMALE; HUMANS; PREGNANCY; PREGNANCY OUTCOME; REGRESSION ANALYSIS;

EID: 84960122494     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev329     Document Type: Article

References (24)

1. Dentali F, Ageno W, Rezoagli E, Rancan E, Squizzato A, Middeldorp S, Margaglione M, Grandone E. Low-dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta-Analysis of the literature. J Thromb Haemost. 2012; 10: 2075-2085.
2. Di Nisio M, Peters L, Middeldorp S. Anticoagulants for the treatment of recurrent pregnancy loss in women without antiphospholipid syndrome. Cochrane Database Syst Rev. 2005; 2: CD004734.
3. Empson M, Lassere M, Craig JC, Scott JR. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol. 2002; 99: 135-144.
4. Empson M, Lassere M, Craig J, Scott J. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev. 2005; 1: CD002859.
5. Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol. 2002; 100: 408-413.
6. Gris JC, Mercier E, Quere I, Lavigne-Lissalde G, Cochery-Nouvellon E, Hoffet M, Ripart-Neveu S, Tailland ML, Dauzat M, Mares P. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood. 2004; 103: 3695-3699.
7. Groeneveld E, Broeze KA, Lambers MJ, Haapsamo M, Dirckx K, Schoot BC, Salle B, Duvan CI, Schats R, Mol BW et al. Is aspirin effective in women undergoing in vitro fertilization (IVF)?. Results from an individual patient data meta-Analysis (IPD MA). Hum Reprod Update. 2011; 17: 501-509.
8. Hernan MA, Hernandez-Diaz S, Robins JM A structural approach to selection bias. Epidemiology. 2004; 15: 615-625.
9. Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S. Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. Cochrane Database Syst Rev. 2009; 1: CD004734.
10. Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulyak K, Mol BW, Folkeringa N, Nahuis M, Papatsonis DN et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med. 2010; 362: 1586-1596.
11. Lathi RB, Gustin SL, Keller J, Maisenbacher MK, Sigurjonsson S, Tao R, Demko Z. Reliability of 46, XX results on miscarriage specimens: a review of 1222 first-Trimester miscarriage specimens. Fertil Steril. 2014; 101: 178-182.
12. Li DK, Liu L, Odouli R. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population based cohort study. Br Med J. 2003; 327: 368.
13. Rai R, Backos M, Baxter N, Chilcott I, Regan L. Recurrent miscarriage-An aspirin a day?. Hum Reprod. 2000; 15: 2220-2223.
14. Robins JM, Hernan MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology. 2000; 11: 550-560.
15. Romero ST, Geiersbach KB, Paxton CN, Rose NC, Schisterman EF, Branch DW, Silver RM. Differentiation of genetic abnormalities in early pregnancy loss. Ultrasound Obstet Gynecol. 2014; 45: 89-94.
16. Schisterman EF, Silver RM, Perkins NJ, Mumford SL, Whitcomb BW, Stanford JB, Lesher LL, Faraggi D, Wactawski-Wende J, Browne RW et al A randomised trial to evaluate the effects of low-dose aspirin in gestation and reproduction: design and baseline characteristics. Paediatr Perinat Epidemiol. 2013; 27: 598-609.
17. Schisterman EF, Silver RM, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, Lynch AM, Perkins NJ, Mumford SL, Galai N. Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Lancet. 2014; 384: 29-36.
18. Silver RM, BranchDW. Sporadic and recurrent pregnancy loss. In: Reece EA, Hobbins JC (eds). Medicine of the Fetus and Mother, 2nd edn. Philadelphia, PA: J.B. Lippincott Company, 1999, 195-216.
19. Silver RM, Branch DW, Goldenberg R, Iams JD, KlebanoffMA.Nomenclature for pregnancy outcomes: time for a change. Obstet Gynecol. 2011; 118: 1402-1408.
20. Siristatidis CS, Dodd SR, Drakeley AJ. Aspirin for in vitro fertilisation. Cochrane Database Syst Rev. 2011; 8: CD004832.
21. Siristatidis CS, Dodd SR, Drakeley AJ. Aspirin is not recommended for women undergoing IVF. Hum Reprod Update. 2012; 18: 233.
22. Tulppala M, Marttunen M, Soderstrom-Anttila V, Foudila T, Ailus K, Palosuo T, Ylikorkala O. Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod. 1997; 12: 1567-1572.
23. Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res. 2003; 110: 255-258.
24. Wilcox AJ, Baird DD, Weinberg CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med. 1999; 340: 1796-1799.